NCBP1 - nuclear cap binding protein subunit 1 Gene

中文名称：核帽结合蛋白亚基 1

种属: Homo sapiens

同用名: NCBP; Sto1; CBP80

基因 ID: 4686 | 基因类型: protein coding

关于 NCBP1

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,633,821-97,673,748 (from NCBI)

This gene has 5 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 9.3), lymph node (RPKM 7.9) and 25 other tissues.

功能概要

该基因的产物是核帽结合蛋白复合物 (CBC) 的一个组成部分，它与核质中新生前体 mRNA 的单甲基化 5' 帽结合。编码的蛋白质促进高亲和力 mRNA 帽结合，并与 RNA 聚合酶 II 的 CTD 结合。 CBC 促进 pre-mRNA 剪接、3' 端加工、RNA 核输出和无义介导的 mRNA 衰变。[RefSeq 提供，2008 年 7 月]

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]

NCBP1 基因产物(5)

mRNA	Protein	Name
NM_001351504.2	NP_001338433.1	nuclear cap-binding protein subunit 1 isoform 2
NM_001351505.2	NP_001338434.1	nuclear cap-binding protein subunit 1 isoform 3
NM_001351506.2	NP_001338435.1	nuclear cap-binding protein subunit 1 isoform 3
NM_001351507.2	NP_001338436.1	nuclear cap-binding protein subunit 1 isoform 4
NM_002486.5	NP_002477.1	nuclear cap-binding protein subunit 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA 7-methylguanosine cap binding	IMP IMP: 通过突变表型推断	23793891	GOA
enables molecular adaptor activity	EXP EXP: 通过实验结果推断	11545740	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7478990	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 7-methylguanosine mRNA capping	IDA IDA: 通过直接分析推断	12434151	GOA
involved in RNA catabolic process	IMP IMP: 通过突变表型推断	25578728	GOA
involved in defense response to virus	IMP IMP: 通过突变表型推断	26382858	GOA
involved in histone mRNA metabolic process	IMP IMP: 通过突变表型推断	17499042	GOA
involved in mRNA export from nucleus	IMP IMP: 通过突变表型推断	17190602	GOA
involved in mRNA export from nucleus	IPI IPI: 通过物理相互作用推断	21326824	GOA
involved in mRNA metabolic process	IMP IMP: 通过突变表型推断	9342333	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	21326824	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: 通过直接分析推断	11551508	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: 通过突变表型推断	18369367	GOA
involved in positive regulation of RNA binding	IMP IMP: 通过突变表型推断	23793891	GOA
involved in positive regulation of cell growth	IMP IMP: 通过突变表型推断	26382858	GOA
involved in positive regulation of mRNA 3'-end processing	IMP IMP: 通过突变表型推断	9342333	GOA
involved in positive regulation of mRNA splicing, via spliceosome	IMP IMP: 通过突变表型推断	23793891	GOA
involved in regulation of translational initiation	IDA IDA: 通过直接分析推断	11551508	GOA
involved in snRNA export from nucleus	IMP IMP: 通过突变表型推断	26382858	GOA
involved in spliceosomal complex assembly	IMP IMP: 通过突变表型推断	23793891	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA cap binding complex	IMP IMP: 通过突变表型推断	23793891	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	26382858	GOA
part of nuclear cap binding complex	IDA IDA: 通过直接分析推断	7651522	GOA
part of nuclear cap binding complex	IPI IPI: 通过物理相互作用推断	8069914	GOA
located in nucleus	IDA IDA: 通过直接分析推断	8069914	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	17289661	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCBP1 蛋白结构

MIF4G

MIF4G_like

MIF4G_like_2

0
200
400
600
790 a.a.

蛋白主名

其他名称

nuclear cap-binding protein subunit 1

80 kDa nuclear cap-binding protein

NCBP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NCBP1	Q09161	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	NCBP1	Q09161	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	Comig Non-Denat Gel	19668212
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	Pull Down	19668212
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	Anti Tag CoIP	19668212
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	Anti Bait CoIP	23665581
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	GMS	19668212
Intra	NCBP1	Q09161	POLDIP3	Homo sapiens	Q9BY77	Anti Tag CoIP	18423201
Intra	NCBP1	Q09161	RNF20	Homo sapiens	Q5VTR2	Validated Y2H	32296183
Intra	NCBP1	Q09161	RNF20	Homo sapiens	Q5VTR2	Y2H Array	32296183
Intra	NCBP1	Q09161	RNF20	Homo sapiens	Q5VTR2	Y2H Prey Pooling	32296183
Intra	NCBP1	Q09161	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	NCBP1	Q09161	RPS6	Homo sapiens	P62753	Anti Tag CoIP	18423201
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	X-Ray Diffraction	11545740
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	Y2H	22365833
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	X-Ray Diffraction	12374755
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	BRET	29997244
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	SLC	31467278
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	X-Ray Diffraction	12434151
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	Anti Tag CoIP	26496610
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	Crosslink	29101316
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	Lumier	29997244
Intra	NCBP1	Q09161	NCBP3	Homo sapiens	Q53F19	Y2H	22365833
Intra	NCBP1	Q09161	NCBP3	Homo sapiens	Q53F19	Anti Tag CoIP	32960270
Intra	NCBP1	Q09161	RNF40	Homo sapiens	O75150	Y2H Prey Pooling	32296183
Intra	NCBP1	Q09161	RNF40	Homo sapiens	O75150	Y2H Array	32296183
Intra	NCBP1	Q09161	RNF40	Homo sapiens	O75150	Y2H Pooling	16189514
Intra	NCBP1	Q09161	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	23665581
Intra	NCBP1	Q09161	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	32960270

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09072	NCBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NCBP1	RGD	RGD:1308973
Mus musculus	NCBP1	MGD	MGI:1891840
Felis catus	NCBP1	VGNC	VGNC:68423
Bos taurus	NCBP1	VGNC	VGNC:31907
Canis familiaris	NCBP1	VGNC	VGNC:43645
Macaca mulatta	NCBP1	VGNC	VGNC:75138

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NCBP1 - nuclear cap binding protein subunit 1 Gene

关于 NCBP1

功能概要

NCBP1 基因产物(5)

NCBP1 蛋白结构

NCBP1 蛋白互作信息

直系同源

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NCBP1 - nuclear cap binding protein subunit 1 Gene

关于 NCBP1

功能概要

NCBP1 基因产物(5)

NCBP1 蛋白结构

NCBP1 蛋白互作信息

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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