NCBP2 - nuclear cap binding protein subunit 2 Gene

中文名称：核帽结合蛋白亚基 2

种属: Homo sapiens

同用名: CBC2; NIP1; CBP20; PIG55

关于 NCBP2

功能概要

该基因的产物是核帽结合蛋白复合物 (CBC) 的一个组成部分，它与核质中新生前体 mRNA 的单甲基化 5' 帽结合。编码的蛋白质具有 RNA 结合蛋白中常见的 RNP 结构域，并包含帽结合活性。 CBC 促进 pre-mRNA 剪接、3' 端加工、RNA 核输出和无义介导的 mRNA 衰变。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]