2. Gene
  3. RPS6 - ribosomal protein S6 Gene

RPS6 - ribosomal protein S6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S6

种属: Homo sapiens

同用名: S6

基因 ID: 6194 | 基因类型: protein coding

关于 RPS6

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,375,715-19,380,236 (from NCBI)

This gene has 5 transcripts (splice variants) and 184 orthologues. Ubiquitous expression in ovary (RPKM 2180.7), bone marrow (RPKM 1555.2) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码一种细胞质核糖体蛋白，它是 40S 亚基的一个组成部分。该蛋白属于核糖体蛋白的 S6E 家族。它是核糖体中蛋白激酶的主要底物，具有被不同蛋白激酶磷酸化的五个 C 末端丝氨酸残基的亚群。磷酸化由多种刺激物诱导，包括生长因子、肿瘤促进剂和促细胞分裂剂。去磷酸化发生在生长停滞时。该蛋白质可能有助于通过特定类别的 mRNA 的选择性翻译来控制细胞生长和增殖。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS6 基因产物(1)

mRNA Protein Name
NM_001010.3 NP_001001.2 40S ribosomal protein S6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16314389 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
21418524 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
8706699 GOA
enables structural constituent of ribosome IMP
IMP: 通过突变表型推断
18697920 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in TOR signaling IDA
IDA: 通过直接分析推断
16428328 GOA
involved in cytoplasmic translation IDA
IDA: 通过直接分析推断
8706699 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
18362888 GOA
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17220279 GOA
involved in rRNA processing IMP
IMP: 通过突变表型推断
18697920 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
involved in ribosomal small subunit biogenesis IMP
IMP: 通过突变表型推断
18697920 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell body IDA
IDA: 通过直接分析推断
15121898 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: 通过直接分析推断
15121898 GOA
is active in cytosolic ribosome IDA
IDA: 通过直接分析推断
8706699 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: 通过直接分析推断
8706699 GOA
located in dendrite IDA
IDA: 通过直接分析推断
15121898 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
8590812 GOA
located in nucleus IDA
IDA: 通过直接分析推断
2334893 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
18809582 GOA
part of small ribosomal subunit IDA
IDA: 通过直接分析推断
15590835 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS6 蛋白结构

Ribosomal_S6e

Ribosomal_S6e: Ribosomal protein S6e (1 - 127)

  • 0
  • 100
  • 200
  • 249 a.a.
蛋白主名 其他名称

40S ribosomal protein S6

phosphoprotein NP33

RPS6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPS6 P62753 PASK Homo sapiens Q96RG2
Peptide Array
21418524
Intra RPS6 P62753 PASK Homo sapiens Q96RG2
Protein Kinase Assay
21418524
Cross RPS6 P62753 N SARS-CoV-2 P0DTC9
Y2H Array
36217030
Intra RPS6 P62753 NCBP1 Homo sapiens Q09161
Anti Tag CoIP
18423201
Intra RPS6 P62753 NCBP1 Homo sapiens Q09161
Anti Bait CoIP
18423201
Intra RPS6 P62753 NPM1 Homo sapiens P06748
Crosslink
30021884
Intra RPS6 P62753 NPM1 Homo sapiens P06748
BioID
29568061
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tuberous Sclerosis

Tuberous Sclerosis Syndrome

Bourneville'S Disease

Epiloia

Cerebral Sclerosis

Tuberose Sclerosis

Tuberous Sclerosis 1

Bourneville Disease

Bourneville Phakomatosis

Pringle'S Disease
Lymphangioleiomyomatosis

Lymphangiomyomatosis

LAM

Lung Lymphangioleiomyomatosis

Pulmonary Lymphangioleiomyomatosis

Lymphangioleiomyomatosis, Somatic

Lymphangio-Myomatosis
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Muscle Hypertrophy

MSLHP

Hypertrophy

Hypertrophy, Muscle
Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease
Subependymal Glioma

Mixed Subependymoma-Ependymoma

Subependymal Astrocytoma

Who Grade I Ependymal Tumor

Glioma, Subependymal
Kidney Angiomyolipoma

Angiomyolipoma Of Kidney

Renal Angiomyolipoma
Diamond-Blackfan Anemia 6

DBA6

Aase-Smith Syndrome Ii

Aase Syndrome

Aase Smith Syndrome 2

Rpl5-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 6

Diamond-Blackfan Anemia 1
Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Pyriform Sinus Cancer

Malignant Neoplasm Of Pyriform Fossa

Malignant Neoplasm Of The Pyriform Fossa

Malignant Tumor Of Pyriform Fossa
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Cowden Syndrome

Cowden Disease

Multiple Hamartoma Syndrome

Cowden'S Disease

Lhermitte-Duclos Disease

Cd

Cs

Mham

Dysplastic Gangliocytoma Of Cerebellum

Cowden'S Syndrome

Hamartoma Syndrome, Multiple
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (32)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123919 TL13-112 Inhibitor 98.15% 否
HY-148062 RSS0680 98.03% 否
HY-148063 DB0614 98.80% 否
HY-122582 TL13-12 Inhibitor 98.06% 否
HY-148061 DB1113 99.28% 否
HY-148065 FMF-06-098-1 / 否
HY-150643 RSK2-IN-2 Inhibitor / 否
HY-150717 RSK2-IN-3 Inhibitor / 否
HY-161874 RPS6-IN-1 / 否
HY-RS12247 RPS6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12248 RPS6KA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12249 Rps6ka1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12250 Rps6ka1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12251 RPS6KA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12252 Rps6ka2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12253 Rps6ka2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12254 RPS6KA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12255 Rps6ka3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12256 Rps6ka3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12257 RPS6KA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12258 RPS6KA5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12259 RPS6KA6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12260 Rps6ka6 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12261 Rps6ka6 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12262 RPS6KB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12263 Rps6kb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12264 Rps6kb1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12265 RPS6KB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12266 Rps6kb2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12267 Rps6kb2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12268 RPS6KC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-50733 CX-5011 free base / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPS6 MGD MGI:98159
Felis catus RPS6 VGNC VGNC:97612
Rattus norvegicus RPS6 RGD RGD:3602
Others RPS6 NCBI
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