2. Gene
  3. PASK - PAS domain containing serine/threonine kinase Gene

PASK - PAS domain containing serine/threonine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含丝氨酸/苏氨酸激酶的 PAS 结构域

种属: Homo sapiens

同用名: STK37; PASKIN

基因 ID: 23178 | 基因类型: protein coding

关于 PASK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,106,099-241,150,347 (from NCBI)

This gene has 16 transcripts (splice variants) and 198 orthologues. Broad expression in testis (RPKM 7.9), lymph node (RPKM 6.8) and 21 other tissues.

功能概要

该基因编码包含两个 PAS 结构域的丝氨酸/苏氨酸激酶家族成员。该基因的表达受葡萄糖调控，所编码的蛋白在胰岛素基因表达调控中发挥作用。该基因的下调可能在 2 型糖尿病中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of Insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

PASK 基因产物(5)

mRNA Protein Name
NM_001252119.2 NP_001239048.1 PAS domain-containing serine/threonine-protein kinase isoform 1
NM_001252120.2 NP_001239049.1 PAS domain-containing serine/threonine-protein kinase isoform 2
NM_001252122.2 NP_001239051.1 PAS domain-containing serine/threonine-protein kinase isoform 3
NM_001252124.2 NP_001239053.1 PAS domain-containing serine/threonine-protein kinase isoform 4
NM_015148.4 NP_055963.2 PAS domain-containing serine/threonine-protein kinase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol binding IDA
IDA: 通过直接分析推断
21418524 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16275910 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
16275910 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of glycogen biosynthetic process IDA
IDA: 通过直接分析推断
16275910 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
20943661 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
16275910 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17595531 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17595531 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PASK 蛋白结构

PAS_9

PAS_9: PAS domain (133 - 224)

Pkinase

Pkinase: Protein kinase domain (999 - 1251)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1323 a.a.
蛋白主名 其他名称

PAS domain-containing serine/threonine-protein kinase

per-arnt-sim (PAS) domain kinase

PASK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PASK Q96RG2 RPS6 Homo sapiens P62753
Protein Kinase Assay
21418524
Intra PASK Q96RG2 CREB1 Homo sapiens P16220
Protein Kinase Assay
21418524
Intra PASK Q96RG2 PHKB Homo sapiens Q93100
Protein Kinase Assay
21418524
Cross PASK Q96RG2 CACNA1S Oryctolagus cuniculus P07293
Peptide Array
21418524
Cross PASK Q96RG2 TNNI3 Oryctolagus cuniculus P02646
Peptide Array
21418524
Cross PASK Q96RG2 GFAP Bos taurus Q28115
Peptide Array
21418524
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C

NPC1

Niemann-Pick Disease, Type D

Niemann-Pick Disease Type C1

Niemann-Pick Disease With Cholesterol Esterification Block

Niemann-Pick Disease, Subacute Juvenile Form

Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia

Npc

Niemann-Pick Disease, Chronic Neuronopathic Form

Niemann-Pick Disease Without Sphingomyelinase Deficiency

Niemann-Pick Disease Type C

Niemann-Pick Disease Type D

Niemann-Pick C1 Disease

Niemann-Pick Disease C1

Niemann-Pick Disease Chronic Neuronopathic Form

Niemann-Pick Disease Nova Scotian Type

Niemann-Pick Disease Subacute Juvenile Form

Niemann-Pick Disease Type Ii

Niemann-Picks Disease Type C
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-129571 BioE-1115 Inhibitor 99.56% 否
HY-152247 DDO3711 Inhibitor / 否
HY-RS10078 PASK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PASK MGD MGI:2155936
Felis catus PASK VGNC VGNC:64048
Canis familiaris PASK VGNC VGNC:44270
Macaca mulatta PASK VGNC VGNC:75638
Rattus norvegicus PASK RGD RGD:1306146
Bos taurus PASK VGNC VGNC:58397
Others PASK NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z