2. Gene
  3. POLDIP3 - DNA polymerase delta interacting protein 3 Gene

POLDIP3 - DNA polymerase delta interacting protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DNA 聚合酶δ相互作用蛋白 3

种属: Homo sapiens

同用名: SKAR; PDIP3; PDIP46

基因 ID: 84271 | 基因类型: protein coding

关于 POLDIP3

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,583,721-42,614,883 (from NCBI)

This gene has 8 transcripts (splice variants), 213 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 49.2), bone marrow (RPKM 26.9) and 25 other tissues.

功能概要

该基因编码一种含有 RRM (RNA 识别基序) 的蛋白质，该蛋白质通过将核糖体蛋白 S6 激酶 beta-1 募集到 mRNA 来参与翻译调节。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

POLDIP3 基因产物(4)

mRNA Protein Name
NM_001278657.2 NP_001265586.1 polymerase delta-interacting protein 3 isoform 3
NM_001363052.2 NP_001349981.1 polymerase delta-interacting protein 3 isoform 4
NM_032311.5 NP_115687.2 polymerase delta-interacting protein 3 isoform 1
NM_178136.3 NP_835237.1 polymerase delta-interacting protein 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18423201 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
18423201 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in poly(A)+ mRNA export from nucleus IDA
IDA: 通过直接分析推断
22928037 GOA
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
18423201 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear speck IDA
IDA: 通过直接分析推断
18423201 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLDIP3 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (284 - 344)

  • 0
  • 100
  • 200
  • 300
  • 421 a.a.
蛋白主名 其他名称

polymerase delta-interacting protein 3

46 kDa DNA polymerase delta interaction protein

POLDIP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra POLDIP3 Q9BY77 NCBP1 Homo sapiens Q09161
Anti Bait CoIP
18423201
Intra POLDIP3 Q9BY77 UBR1 Homo sapiens Q8IWV7
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Methylmalonic Aciduria, Cblb Type

Methylmalonic Aciduria Cblb Type

Methylmalonic Acidemia Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type

Methylmalonic Acidemia, Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type

Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb

Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb

Methylmalonic Aciduria Type Cblb

MMAB

Methylmalonic Aciduria Type B

Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B

Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B

Aciduria, Methylmalonic, Cblb Type

Methylmalonic Acidemia

Methylmalonic Aciduria
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10824 POLDIP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus POLDIP3 MGD MGI:1921076
Canis familiaris POLDIP3 VGNC VGNC:44778
Rattus norvegicus POLDIP3 RGD RGD:1311073
Macaca mulatta POLDIP3 VGNC VGNC:97119
Bos taurus POLDIP3 VGNC VGNC:33117
Felis catus POLDIP3 VGNC VGNC:64284
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