2. Gene
  3. NANOS2 - nanos C2HC-type zinc finger 2 Gene

NANOS2 - nanos C2HC-type zinc finger 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：nanos C2HC 型锌指 2

种属: Homo sapiens

同用名: NOS2; ZC2HC12B

基因 ID: 339345 | 基因类型: protein coding

关于 NANOS2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,913,214-45,914,778 (from NCBI)

This gene has 1 transcript (splice variant), 231 orthologues and 2 paralogues.

功能概要

预测启用 mRNA 结合活性。参与翻译的负调节和核转录 mRNA 分解代谢过程的正调节，脱腺苷酸化依赖性衰变。位于细胞质的细胞核和核周区。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable mRNA binding activity. Involved in negative regulation of translation and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NANOS2 基因产物(1)

mRNA Protein Name
NM_001029861.3 NP_001025032.1 nanos homolog 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme activator activity IDA
IDA: 通过直接分析推断
24736845 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24736845 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA destabilization IDA
IDA: 通过直接分析推断
24736845 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
24736845 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19168545 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22899867 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
19168545 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NANOS2 蛋白结构

zf-nanos

zf-nanos: Nanos RNA binding domain (63 - 116)

  • 0
  • 100
  • 138 a.a.
蛋白主名 其他名称

nanos homolog 2

NOS-2

NANOS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NANOS2 P60321 S100A10 Homo sapiens P60903
Y2H Prey Pooling
32296183
种属内
NANOS2 P60321 S100A10 Homo sapiens P60903
Validated Y2H
32296183
种属内
NANOS2 P60321 S100A10 Homo sapiens P60903
Y2H Array
32296183
种属内
NANOS2 P60321 CCNDBP1 Homo sapiens O95273
Y2H Array
31515488
种属内
NANOS2 P60321 CCNDBP1 Homo sapiens O95273
Validated Y2H
25416956
种属内
NANOS2 P60321 MAGEA12 Homo sapiens P43365
Y2H Array
32296183
种属内
NANOS2 P60321 MAGEA12 Homo sapiens P43365
Y2H Prey Pooling
25416956
种属内
NANOS2 P60321 MAGEA12 Homo sapiens P43365
Y2H Prey Pooling
32296183
种属内
NANOS2 P60321 MAGEA12 Homo sapiens P43365
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group L

Fanconi Anemia Complementation Group L

FANCL
Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome

Germinal Cell Aplasia

Del Castillo Syndrome

SPGFX1

X-Linked Spermatogenic Failure 1

Congenital Absence Of Germinal Epithelium Of Testes
Spermatocytoma

Spermatocytic Seminoma
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Spermatogenic Failure, Y-Linked, 2

SPGFY2

Spermatogenic Failure, Nonobstructive, Y-Linked

Y-Linked Spermatogenic Failure 2

Azoospermia, Nonobstructive, Y-Linked

Oligozoospermia, Nonobstructive, Y-Linked

Oligospermia, Nonobstructive, Y-Linked

Spermatogenic Arrest, Y-Linked

Nonobstructive Y-Linked Spermatogenic Failure

Spermatogenic Failure Y-Linked 2

Azoospermia Non-Obstructive Y-Linked

Non-Obstructive Azoospermia And Infertility

Oligospermia Non-Obstructive Y-Linked

Oligozoospermia Non-Obstructive Y-Linked

Spermatogenic Arrest Y-Linked

Spermatogenic Failure Nonobstructive Y-Linked
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09022 NANOS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NANOS2 VGNC VGNC:31876
Canis familiaris NANOS2 VGNC VGNC:43614
Macaca mulatta NANOS2 VGNC VGNC:75009
Felis catus NANOS2 VGNC VGNC:63719
Rattus norvegicus NANOS2 RGD RGD:1562436
Mus musculus NANOS2 MGD MGI:2676627
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