2. Gene
  3. NOL7 - nucleolar protein 7 Gene

NOL7 - nucleolar protein 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核仁蛋白 7

种属: Homo sapiens

同用名: PQBP3; RARG-1; C6orf90; dJ223E5.2

基因 ID: 51406 | 基因类型: protein coding

关于 NOL7

Cytogenetic location: 6p23 Genomic coordinates (GRCh38): 6:13,615,335-13,632,470 (from NCBI)

This gene has 3 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in testis (RPKM 25.5), thyroid (RPKM 22.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质定位于核仁，在那里它维持核仁结构和细胞生长速率。所编码的蛋白质还可以作为肿瘤抑制因子和血管生成调节因子发挥作用。 RB 肿瘤抑制基因向该基因募集转录因子并正向调节其表达。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

NOL7 基因产物(2)

mRNA Protein Name
NM_001317724.2 NP_001304653.1 nucleolar protein 7
NM_016167.5 NP_057251.2 nucleolar protein 7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in maturation of SSU-rRNA IMP
IMP: 通过突变表型推断
37246770 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOL7 蛋白结构

NUC129

NUC129: NUC129 domain (172 - 234)

  • 0
  • 100
  • 200
  • 257 a.a.
蛋白主名 其他名称

nucleolar protein 7

nucleolar protein 7, 27kDa

NOL7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NOL7 Q9UMY1 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
种属内
NOL7 Q9UMY1 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Renpenning Syndrome 1

Renpenning Syndrome

Golabi-Ito-Hall Syndrome

Mrxs3

Mrxs8

X-Linked Intellectual Disability Due To Pqbp1 Mutations

RENS1

Sutherland-Haan X-Linked Mental Retardation Syndrome

Shs

Mrx55

X-Linked Intellectual Disability, Renpenning Type

Sutherland-Haan Syndrome

Mental Retardation, X-Linked, Renpenning Type

Mental Retardation, X-Linked, With Spastic Diplegia

Mental Retardation, X-Linked, Syndromic 3

Mental Retardation, X-Linked, Syndromic 8

Mental Retardation, X-Linked 55

Syndromic X-Linked Mental Retardation 8

X-Linked Mental Retardation Renpenning Type

X-Linked Mental Retardation With Spastic Diplegia

Sutherland-Haan X-Linked Intellectual Disability Syndrome

X-Linked Intellectual Disability With Spastic Diplegia

Hamel Cerebropalatocardiac Syndrome

Porteous Syndrome

X-Linked Intellectual Deficit Due To Pqbp1 Mutations

X-Linked Intellectual Deficit, Renpenning Type

X-Linked Intellectual Disability, Sutherland-Haan Type

Hamel Cerebro-Palato-Cardiac Syndrome

Renpenning Syndrome, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09417 NOL7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NOL7 VGNC VGNC:32159
Macaca mulatta NOL7 VGNC VGNC:75226
Mus musculus NOL7 MGD MGI:1917328
Rattus norvegicus NOL7 RGD RGD:1565934
Canis familiaris NOL7 VGNC VGNC:43884
Felis catus NOL7 VGNC VGNC:102476
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