TFPT - TCF3 fusion partner Gene

中文名称：TCF3 融合伙伴

种属: Homo sapiens

同用名: FB1; amida; INO80F

基因 ID: 29844 | 基因类型: protein coding

关于 TFPT

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,107,020-54,115,657 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 109 orthologues and is associated with 46 phenotypes. Ubiquitous expression in brain (RPKM 11.2), prostate (RPKM 8.4) and 25 other tissues.

功能概要

预测启用 DNA 结合活性和蛋白激酶结合活性。参与细胞凋亡信号通路。位于核质中。 Ino80 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA binding activity and protein kinase binding activity. Involved in apoptotic signaling pathway. Located in nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

TFPT 基因产物(2)

mRNA	Protein	Name
NM_001321792.2	NP_001308721.1	TCF3 fusion partner isoform 2
NM_013342.4	NP_037474.1	TCF3 fusion partner isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17395368	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in apoptotic signaling pathway	IDA IDA: 通过直接分析推断	17041757	GOA
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	21303910	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	27641337	GOA
involved in regulation of DNA replication	IMP IMP: 通过突变表型推断	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: 通过突变表型推断	25016522	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: 通过突变表型推断	26340092	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Ino80 complex	IDA IDA: 通过直接分析推断	21303910	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

TCF3 fusion partner

INO80 complex subunit F

TFPT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TFPT	P0C1Z6	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	33961781
Intra	TFPT	P0C1Z6	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	18922472
Intra	TFPT	P0C1Z6	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	TFPT	P0C1Z6	TFIP11	Homo sapiens	Q9UBB9	BFG-2H	27107012
Intra	TFPT	P0C1Z6	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	TFPT	P0C1Z6	EAF2	Homo sapiens	Q96CJ1	Y2H	17395368
Intra	TFPT	P0C1Z6	EAF2	Homo sapiens	Q96CJ1	Anti Tag CoIP	17395368
Intra	TFPT	P0C1Z6	TPM3	Homo sapiens	P06753	BFG-2H	27107012
Intra	TFPT	P0C1Z6	TPM3	Homo sapiens	P06753	Anti Tag CoIP	33961781
Intra	TFPT	P0C1Z6	TPM3	Homo sapiens	P06753	Validated Y2H	27107012
Intra	TFPT	P0C1Z6	TRAF1	Homo sapiens	Q13077	BFG-2H	27107012
Intra	TFPT	P0C1Z6	TRAF1	Homo sapiens	Q13077	Validated Y2H	27107012
Intra	TFPT	P0C1Z6	PSMB1	Homo sapiens	P20618	Validated Y2H	32296183
Intra	TFPT	P0C1Z6	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	TFPT	P0C1Z6	C19orf25	Homo sapiens	Q9UFG5	Validated Y2H	32296183
Intra	TFPT	P0C1Z6	CCNDBP1	Homo sapiens	O95273	BFG-2H	27107012
Intra	TFPT	P0C1Z6	CCNDBP1	Homo sapiens	O95273	Y2H	27107012
Intra	TFPT	P0C1Z6	STK3	Homo sapiens	Q13188	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Childhood Leukemia

B-Lymphoblastic Leukemia/Lymphoma With Hyperdiploidy

B-All With Hyperdiploidy

B Lymphoblastic Leukemia Lymphoma With Hyperdiploidy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14429	TFPT Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	TFPT	VGNC	VGNC:35795
Macaca mulatta	TFPT	VGNC	VGNC:78378
Rattus norvegicus	TFPT	RGD	RGD:620839
Canis familiaris	TFPT	VGNC	VGNC:47303
Mus musculus	TFPT	MGD	MGI:1916964
Felis catus	TFPT	VGNC	VGNC:66125

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