EAF2 - ELL associated factor 2 Gene

中文名称：ELL 相关因素 2

种属: Homo sapiens

同用名: U19; BM040; TRAITS

基因 ID: 55840 | 基因类型: protein coding

关于 EAF2

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,835,209-121,886,526 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 6.9), lymph node (RPKM 6.3) and 18 other tissues.

功能概要

启用转录延伸调节活性。参与 RNA 聚合酶 II 转录的正调控和 RNA 聚合酶 II 启动子转录延伸的调控。转录延伸因子复合体的一部分。前列腺癌的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription elongation regulator activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of transcription elongation from RNA polymerase II promoter. Part of transcription elongation factor complex. Biomarker of prostate Cancer. [provided by Alliance of Genome Resources, Apr 2022]

EAF2 基因产物(2)

mRNA	Protein	Name
NM_001320041.2	NP_001306970.1	ELL-associated factor 2 isoform 2
NM_018456.6	NP_060926.2	ELL-associated factor 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17395368	GOA
enables transcription elongation factor activity	IMP IMP: 通过突变表型推断	32087315	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16114057	GOA
involved in regulation of transcription elongation by RNA polymerase II	IMP IMP: 通过突变表型推断	32087315	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of transcription elongation factor complex	IDA IDA: 通过直接分析推断	22195968	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EAF2 蛋白结构

EAF

0
100
200
260 a.a.

蛋白主名

其他名称

ELL-associated factor 2

testosterone-regulated apoptosis inducer and tumor suppressor protein

EAF2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	EAF2	Q96CJ1	BEND7	Homo sapiens	Q8N7W2-2	BFG-2H	27107012
Intra	EAF2	Q96CJ1	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	25416956
Intra	EAF2	Q96CJ1	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	25416956
Intra	EAF2	Q96CJ1	TFPT	Homo sapiens	P0C1Z6	Y2H	17395368
Intra	EAF2	Q96CJ1	PSME3	Homo sapiens	P61289	Y2H	21516116
Intra	EAF2	Q96CJ1	PSME3	Homo sapiens	P61289	BFG-2H	27107012
Intra	EAF2	Q96CJ1	BIRC2	Homo sapiens	Q13490	Y2H Array	25416956
Intra	EAF2	Q96CJ1	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	EAF2	Q96CJ1	TRIM23	Homo sapiens	P36406	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Eaf

Eosinophilic Angiocentric Fibrosis	Sinonasal Eosinophilic Angiocentric Fibrosis
Igg4-Related Eosinophilic Angiocentric Fibrosis

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04120	EAF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	EAF2	RGD	RGD:628879
Canis familiaris	EAF2	VGNC	VGNC:40172
Macaca mulatta	EAF2	VGNC	VGNC:71884
Felis catus	EAF2	VGNC	VGNC:61701
Mus musculus	EAF2	MGD	MGI:2146616
Bos taurus	EAF2	VGNC	VGNC:28295

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