UCHL5 - ubiquitin C-terminal hydrolase L5 Gene

中文名称：泛素 C 端水解酶 L5

种属: Homo sapiens

同用名: UCH37; CGI-70; INO80R; UCH-L5

基因 ID: 51377 | 基因类型: protein coding

关于 UCHL5

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,012,254-193,060,076 (from NCBI)

This gene has 13 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 5.2), esophagus (RPKM 3.6) and 25 other tissues.

功能概要

启用内肽酶抑制剂活性；蛋白酶体结合活性；和硫醇依赖性去泛素化酶。参与蛋白酶体泛素依赖性蛋白质分解代谢过程的负调控；平滑信号通路的正向调节；和蛋白质去泛素化。位于胞质溶胶中；核仁;和核质。与 Ino80 复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables endopeptidase inhibitor activity; Proteasome binding activity; and thiol-dependent Deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

UCHL5 基因产物(17)

mRNA	Protein	Name
NM_001199261.3	NP_001186190.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2
NM_001199262.3	NP_001186191.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3
NM_001199263.3	NP_001186192.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4
NM_001350840.2	NP_001337769.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 5
NM_001350841.2	NP_001337770.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 6
NM_001350842.2	NP_001337771.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 7
NM_001350843.2	NP_001337772.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 8
NM_001350844.2	NP_001337773.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 9
NM_001350845.2	NP_001337774.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 10
NM_001350846.2	NP_001337775.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 11
NM_001350847.2	NP_001337776.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 12
NM_001350848.2	NP_001337777.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13
NM_001350849.2	NP_001337778.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13
NM_001350850.2	NP_001337779.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14
NM_001350851.2	NP_001337780.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14
NM_001350852.2	NP_001337781.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 15
NM_015984.5	NP_057068.1	ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type deubiquitinase activity	IDA IDA: 通过直接分析推断	18922472	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: 通过突变表型推断	28992318	GOA
enables endopeptidase inhibitor activity	IMP IMP: 通过突变表型推断	18162577	GOA
enables proteasome binding	IDA IDA: 通过直接分析推断	18162577	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11163772	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	21303910	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	23770237	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	27641337	GOA
involved in positive regulation of smoothened signaling pathway	IMP IMP: 通过突变表型推断	28992318	GOA
involved in protein deubiquitination	IDA IDA: 通过直接分析推断	18922472	GOA
involved in regulation of DNA replication	IMP IMP: 通过突变表型推断	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: 通过突变表型推断	25016522	GOA
involved in regulation of cell cycle	IMP IMP: 通过突变表型推断	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: 通过突变表型推断	26340092	GOA
involved in regulation of proteasomal protein catabolic process	IMP IMP: 通过突变表型推断	18162577	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Ino80 complex	IDA IDA: 通过直接分析推断	18922472	GOA
located in cytosol	IDA IDA: 通过直接分析推断	18922472	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18922472	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UCHL5 蛋白结构

Peptidase_C12

0
100
200
300
329 a.a.

蛋白主名

其他名称

ubiquitin carboxyl-terminal hydrolase isozyme L5

INO80 complex subunit R

UCHL5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UCHL5	Q9Y5K5	TFPT	Homo sapiens	P0C1Z6	Anti Tag CoIP	19615732
种属内	UCHL5	Q9Y5K5	TFPT	Homo sapiens	P0C1Z6	Anti Tag CoIP	18922472
种属内	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Anti Tag CoIP	33961781
种属内	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Anti Tag CoIP	18922472
种属内	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Y2H Prey Pooling	25416956
种属内	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Validated Y2H	25416956
种属内	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Anti Tag CoIP	19615732
种属内	UCHL5	Q9Y5K5	NFRKB	Homo sapiens	Q6P4R8	Pull Down	18922472
种属内	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	19490896
种属内	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	18922472
种属内	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	19615732
种属内	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	16990800
种属内	UCHL5	Q9Y5K5	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	33961781
种属内	UCHL5	Q9Y5K5	PSMA6	Homo sapiens	P60900	Anti Tag CoIP	19490896
种属内	UCHL5	Q9Y5K5	PSMA6	Homo sapiens	P60900	Anti Tag CoIP	18922472
种属内	UCHL5	Q9Y5K5	PSMA6	Homo sapiens	P60900	Anti Tag CoIP	16990800
种属内	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	19615732
种属内	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	33961781
种属内	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Pull Down	17139257
种属内	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	19490896
种属内	UCHL5	Q9Y5K5	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	18922472
种属内	UCHL5	Q9Y5K5	INO80E	Homo sapiens	Q8NBZ0	Anti Tag CoIP	18922472
种属内	UCHL5	Q9Y5K5	INO80E	Homo sapiens	Q8NBZ0	Anti Tag CoIP	19615732
种属内	UCHL5	Q9Y5K5	ACTR8	Homo sapiens	Q9H981	Anti Tag CoIP	33961781
种属内	UCHL5	Q9Y5K5	ACTR8	Homo sapiens	Q9H981	Anti Tag CoIP	18922472
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	33961781
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Y2H	21516116
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Pull Down	17139257
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Density Sedimentation	16990800
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	18922472
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Y2H Prey Pooling	25416956
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	19615732
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Validated Y2H	25416956
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	19490896
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Pull Down	16990800
种属内	UCHL5	Q9Y5K5	ADRM1	Homo sapiens	Q16186	Anti Tag CoIP	16990800

种属间: 跨种属相互作用 种属内: 同种属相互作用

UCHL5 抗体

目录号	产品名	应用	反应物种
HY-P82594	UCHL5 Antibody (YA2339)	WB, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-13989	b-AP15		98.57%	否
HY-149230	USP28-IN-4	Inhibitor	99.35%	否
HY-149229	USP28-IN-3	Inhibitor	98.26%	否
HY-149228	USP28-IN-2	Inhibitor	/	否
HY-164689	Cadmium pyrithione	Inhibitor	/	否
HY-RS15402	UCHL5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	UCHL5	VGNC	VGNC:97678
Canis familiaris	UCHL5	VGNC	VGNC:48105
Mus musculus	UCHL5	MGD	MGI:1914848
Bos taurus	UCHL5	VGNC	VGNC:36633
Rattus norvegicus	UCHL5	RGD	RGD:1305414
Macaca mulatta	UCHL5	VGNC	VGNC:79197
Others	UCHL5	NCBI

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