2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. USP28-IN-2

USP28-IN-2 是一种 USP28 抑制剂 (IC50=0.3 μM)，对 USP2、USP7、USP8、USP9x、UCHL3 和 UCHL5具有高选择性。USP28-IN-2 显示出对癌细胞的细胞毒性，通过泛素-蛋白酶体系统下调 c-Myc 的细胞水平。USP28-IN-2 还在体外降低 Ankyrase-1/2 水平。USP28-IN-2 增强结直肠癌细胞对瑞戈非尼 (HY-10331) 的敏感性。

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USP28-IN-2 Chemical Structure

USP28-IN-2 Chemical Structure

CAS No. : 2931509-11-2

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USP28-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Deubiquitinase 亚型特异性产品:

查看所有亚型
USP1 USP2 USP7 USP8 USP30 UCHL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1].

IC50 & Target[1]

USP28

0.3 μM (IC50)

体外研究
(In Vitro)

USP28-IN-2 (compound 9l) (15 μM，17.5 μM；3 d) 抑制人结直肠癌细胞 HCT116 (17.5 μM) 和 Ls174T (15 μM) 的集落形成[1]。
USP28-IN-2 (20-80 μM；24 小时) 通过泛素-蛋白酶体系统 (UPS) 增强其降解，从而下调 c-Myc 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

USP28-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: Human colorectal cancer cells HCT116 and Ls174T
Concentration: 20 μM, 30 μM, 50 μM, and 60 μM, for Ls174T; 30 μM, 50 μM, 60 μM and 80 μM for HCT116
Incubation Time: 24 h
Result: Dose-dependently down-regulated the cellular level of c-Myc.
分子量

475.39

Formula

C23H20Cl2N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

USP28-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

USP28-IN-22931509-11-2DeubiquitinaseDUBsUSP28USP2USP7USP8USP9xUCHL3UCHL5. USP28-IN-2c-Mycubiquitin-proteasome systemankyrase-1/2colorectal cancer cellInhibitorinhibitorinhibit

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产品名称：
USP28-IN-2
目录号：
HY-149228
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