ADRM1 - ADRM1 26S proteasome ubiquitin receptor Gene

中文名称：ADRM1 26S 蛋白酶体泛素受体

种属: Homo sapiens

同用名: ARM1; ARM-1; GP110; PSMD16

关于 ADRM1

功能概要

该基因编码粘附调节分子 1 蛋白家族的成员。编码的蛋白质是蛋白酶体的一个组成部分，它充当泛素受体并募集去泛素化酶泛素羧基末端水解酶 L5。编码蛋白水平的增加与细胞粘附的增加有关，这可能是这种细胞内蛋白的间接影响。该基因的失调与致癌作用有关。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the Proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating Enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]