2. Gene
  3. RAD23B - RAD23 homolog B, nucleotide excision repair protein Gene

RAD23B - RAD23 homolog B, nucleotide excision repair protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAD23 同系物 B，核苷酸切除修复蛋白

种属: Homo sapiens

同用名: P58; HR23B; HHR23B

基因 ID: 5887 | 基因类型: protein coding

关于 RAD23B

Cytogenetic location: 9q31.2 Genomic coordinates (GRCh38): 9:107,283,279-107,332,194 (from NCBI)

This gene has 5 transcripts (splice variants), 232 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 44.7), fat (RPKM 43.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质是酿酒酵母 Rad23 的两个人类同系物之一，这是一种参与核苷酸切除修复 (NER) 的蛋白质。发现该蛋白质是蛋白质复合物的一个组分，该蛋白质复合物在体外特异性补充着色性干皮病 C 组 (XP-c) 细胞提取物的 NER 缺陷。该蛋白质还显示与 3-甲基腺嘌呤-DNA 糖基化酶 (MPG) 相互作用并提高其核苷酸切除活性，这表明在碱基切除修复中的 DNA 损伤识别中发挥作用。该蛋白含有一个 N 端泛素样结构域，据报道该结构域与 26S 蛋白酶体相互作用，因此该蛋白可能参与细胞中泛素介导的蛋白水解途径。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S Proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

RAD23B 基因产物(3)

mRNA Protein Name
NM_001244713.1 NP_001231642.1 UV excision repair protein RAD23 homolog B isoform 2
NM_001244724.2 NP_001231653.1 UV excision repair protein RAD23 homolog B isoform 3
NM_002874.5 NP_002865.1 UV excision repair protein RAD23 homolog B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA damage sensor activity IDA
IDA: 通过直接分析推断
19941824 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
19435460 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10488153 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in nucleotide-excision repair IDA
IDA: 通过直接分析推断
8168482 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
19435460 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of XPC complex IDA
IDA: 通过直接分析推断
11279143 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAD23B 蛋白结构

ubiquitin

ubiquitin: Ubiquitin family (6 - 77)

UBA

UBA: UBA/TS-N domain (190 - 225)

XPC-binding

XPC-binding: XPC-binding domain (276 - 333)

UBA

UBA: UBA/TS-N domain (367 - 401)

  • 0
  • 100
  • 200
  • 300
  • 409 a.a.
蛋白主名 其他名称

UV excision repair protein RAD23 homolog B

RAD23, yeast homolog of, B

RAD23B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Validated Y2H
32296183
Intra RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Y2H Array
25416956
Intra RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Y2H Array
32296183
Intra RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
25416956
Intra RAD23B P54727 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
32296183
Intra RAD23B P54727 PUF60 Homo sapiens Q9UHX1
Y2H Prey Pooling
25416956
Intra RAD23B P54727 PUF60 Homo sapiens Q9UHX1
Y2H Array
25416956
Intra RAD23B P54727 PUF60 Homo sapiens Q9UHX1-2
Y2H Array
32296183
Intra RAD23B P54727 PUF60 Homo sapiens Q9UHX1-2
Y2H Prey Pooling
32296183
Intra RAD23B P54727 PUF60 Homo sapiens Q9UHX1-2
Validated Y2H
32296183
Intra RAD23B P54727 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra RAD23B P54727 POU6F2 Homo sapiens P78424
Validated Y2H
32296183
Intra RAD23B P54727 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Cross RAD23B P54727 Pax3 Mus musculus P24610
Pull Down
17662948
Intra RAD23B P54727 USP25 Homo sapiens Q9UHP3
Y2H Prey Pooling
32296183
Intra RAD23B P54727 USP25 Homo sapiens Q9UHP3
Anti Tag CoIP
33961781
Intra RAD23B P54727 USP25 Homo sapiens Q9UHP3
Anti Tag CoIP
28514442
Intra RAD23B P54727 USP25 Homo sapiens Q9UHP3
Validated Y2H
32296183
Intra RAD23B P54727 USP25 Homo sapiens Q9UHP3
Y2H Array
32296183
Intra RAD23B P54727 UBC Homo sapiens P0CG48
Y2H Prey Pooling
32296183
Intra RAD23B P54727 UBC Homo sapiens P0CG48
Y2H Array
32296183
Intra RAD23B P54727 VIM Homo sapiens P08670
Pull Down
16712842
Intra RAD23B P54727 PSMD4 Homo sapiens P55036
Density Sedimentation
10488153
Intra RAD23B P54727 PSMD4 Homo sapiens P55036
Y2H Prey Pooling
32296183
Intra RAD23B P54727 PSMD4 Homo sapiens P55036
Validated Y2H
32296183
Intra RAD23B P54727 PSMD4 Homo sapiens P55036
Y2H Array
32296183
Intra RAD23B P54727 PSMD4 Homo sapiens P55036
Pull Down
20059542
Intra RAD23B P54727 PSMD4 Homo sapiens P55036
Pull Down
10488153
Intra RAD23B P54727 PSMC2 Homo sapiens P35998
Pull Down
16712842
Intra RAD23B P54727 XPC Homo sapiens Q01831
Anti Tag CoIP
33961781
Intra RAD23B P54727 XPC Homo sapiens Q01831
Anti Tag CoIP
28514442
Intra RAD23B P54727 XPC Homo sapiens Q01831
Affinity Chrom
21962512
Intra RAD23B P54727 MKRN1 Homo sapiens Q9UHC7
Y2H Array
32296183
Intra RAD23B P54727 MKRN1 Homo sapiens Q9UHC7
Y2H Prey Pooling
32296183
Intra RAD23B P54727 MKRN1 Homo sapiens Q9UHC7
Validated Y2H
32296183
Intra RAD23B P54727 RSC1A1 Homo sapiens Q92681
Validated Y2H
32296183
Intra RAD23B P54727 RSC1A1 Homo sapiens Q92681
Y2H Prey Pooling
32296183
Intra RAD23B P54727 RSC1A1 Homo sapiens Q92681
Y2H Array
32296183
Intra RAD23B P54727 UBB Homo sapiens P0CG47
Y2H Prey Pooling
32296183
Intra RAD23B P54727 UBB Homo sapiens P0CG47
Pull Down
17662948
Intra RAD23B P54727 UBB Homo sapiens P0CG47
Y2H Array
32296183
Intra RAD23B P54727 HIP1 Homo sapiens O00291
Y2H Array
32296183
Intra RAD23B P54727 HIP1 Homo sapiens O00291
Y2H Prey Pooling
32296183
Intra RAD23B P54727 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra RAD23B P54727 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
32296183
Intra RAD23B P54727 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Y2H Prey Pooling
25416956
Intra RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Anti Tag CoIP
33961781
Intra RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Validated Y2H
25416956
Intra RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Anti Tag CoIP
28514442
Intra RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Validated Y2H
32296183
Intra RAD23B P54727 NGLY1 Homo sapiens Q96IV0
Y2H Array
25416956
Intra RAD23B P54727 UBA3 Homo sapiens Q8TBC4
Pull Down
16712842
Intra RAD23B P54727 USP5 Homo sapiens P45974
Pull Down
16712842
Intra RAD23B P54727 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra RAD23B P54727 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra RAD23B P54727 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra RAD23B P54727 ADRM1 Homo sapiens Q16186
Pull Down
20059542
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C

XPC

Xpcc

Xeroderma Pigmentosum Iii

Xp3

Xeroderma Pigmentosum Group C

Xp Group C

Xp, Group C

Xeroderma Pigmentosum, Type 3

Xeroderma Pigmentosum Complementation Group C

XP-C
Xeroderma Pigmentosum, Complementation Group G

Xeroderma Pigmentosum, Group G

Xeroderma Pigmentosum Vii

Xp7

XPG

Xeroderma Pigmentosum Group G

Xp Group G

Xp, Group G

Xpgc

Xeroderma Pigmentosum, Group G/Cockayne Syndrome

Xeroderma Pigmentosum, Type 7

Xeroderma Pigmentosum Complementation Group G

XP-G

Xp-G/Cs

Xeroderma Pigmentosum Group G/Cockayne Syndrome
Xeroderma Pigmentosum, Complementation Group A

Xeroderma Pigmentosum Group A

Xp1

Xeroderma Pigmentosum, Group A

XPA

Xeroderma Pigmentosum I

Xeroderma Pigmentosum Complementation Group A

Xp Group A

Xp, Group A

Xeroderma Pigmentosum 1

Xeroderma Pigmentosum, Type 1

XP-A
Xeroderma Pigmentosum, Complementation Group F

Xeroderma Pigmentosum, Group F

Xeroderma Pigmentosum Vi

Xp6

Xeroderma Pigmentosum, Type F/Cockayne Syndrome

XPF

Xp, Group F

Xeroderma Pigmentosum Group F

Xp Group F

Xeroderma Pigmentosum, Type 6

Xeroderma Pigmentosum Complementation Group F

XP-F

Xeroderma Pigmentosum Type F/Cockayne Syndrome

XPF/CS
Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1
Cockayne Syndrome B

Cockayne Syndrome Type 2

Cockayne Syndrome, Type B

Cockayne Syndrome Type Ii

CSB

Cockayne Syndrome 2

Cockayne Syndrome Type B

Ckn2

Cockayne Syndrome, Type Ii
De Sanctis-Cacchione Syndrome

Xerodermic Idiocy

Xeroderma Pigmentosum With Neurologic Manifestation

DSC

Xerodermic Idiocy Of De Sanctis And Cacchione
Uv-Sensitive Syndrome

Uvss

Uv Sensitive Syndrome

Ultraviolet Sensitive Syndrome
Trichothiodystrophy

Ttd

Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

Ibids

Pibids

Trichothiodystrophy Syndromes
Cerebrooculofacioskeletal Syndrome

Cerebro-Oculo-Facio-Skeletal Syndrome

Cofs Syndrome

Pena-Shokeir Syndrome Type 2

Pena Shokeir Syndrome Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11601 RAD23B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RAD23B MGD MGI:105128
Bos taurus RAD23B VGNC VGNC:33683
Macaca mulatta RAD23B VGNC VGNC:76644
Rattus norvegicus RAD23B RGD RGD:1562958
Canis familiaris RAD23B VGNC VGNC:45316
Felis catus RAD23B VGNC VGNC:69214
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z