UBA3 - ubiquitin like modifier activating enzyme 3 Gene

中文名称：泛素样修饰激活酶 3

种属: Homo sapiens

同用名: NAE2; UBE1C; hUBA3

关于 UBA3

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E1 泛素激活酶家族的成员。编码的酶与淀粉样蛋白 β 前体蛋白结合蛋白 AppBp1 结合形成异二聚体，然后酶复合物激活 NEDD8，这是一种泛素样蛋白，可调节细胞分裂、信号传导和胚胎发生。已经为该基因发现了编码不同亚型的多个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating Enzyme family. The encoded Enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the Enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]