NAE1 - NEDD8 activating enzyme E1 subunit 1 Gene

中文名称：NEDD8 激活酶 E1 亚基 1

种属: Homo sapiens

同用名: HPP1; ula-1; APPBP1; A-116A10.1

关于 NAE1

功能概要

由该基因编码的蛋白质与 β-淀粉样蛋白前体蛋白结合。 β-淀粉样蛋白前体蛋白是一种具有信号转导特性的细胞表面蛋白，被认为在阿尔茨海默病的发病机制中发挥作用。此外，编码的蛋白质可以与 UBE1C 形成异二聚体，并结合并激活泛素样蛋白 NEDD8。这种蛋白质是通过 S/M 检查点的细胞周期进程所必需的。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]