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  2. CPNE2 - copine 2 Gene

CPNE2 - copine 2 Gene

中文名称:应对 2

种属: Homo sapiens

同用名: CPN2; COPN2

基因 ID: 221184 | 基因类型: protein coding

关于 CPNE2

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:57,092,583-57,148,369 (from NCBI)

This gene has 10 transcripts (splice variants), 217 orthologues and 8 paralogues. Ubiquitous expression in lung (RPKM 25.9), fat (RPKM 23.8) and 24 other tissues.

功能概要

钙依赖性膜结合蛋白可以调节细胞膜和细胞质界面处的分子事件。该基因是编码钙依赖性蛋白质的几个基因之一,该蛋白质包含两个 N 末端 II 型 C2 结构域和 C 末端的整合素 A 结构域样序列。序列分析确定了多个选择性剪接的转录本变体,但无法确定它们的全长性质。[RefSeq 提供,2008 年 7 月]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an Integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined. [provided by RefSeq, Jul 2008]

CPNE2 基因产物(1)

mRNA Protein Name
NM_152727.6 NP_689940.3 copine-2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CPNE2 蛋白结构

C2

C2: C2 domain (30 - 114)

C2

C2: C2 domain (162 - 245)

Copine

Copine: Copine (326 - 473)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 548 a.a.
蛋白主名 其他名称

copine-2

copine II

CPNE2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CPNE2 Q96FN4 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra CPNE2 Q96FN4 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 NCKIPSD Homo sapiens Q9NZQ3-3
Validated Y2H
32296183
Intra CPNE2 Q96FN4 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Array
32296183
Intra CPNE2 Q96FN4 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra CPNE2 Q96FN4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra CPNE2 Q96FN4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra CPNE2 Q96FN4 GBP7 Homo sapiens Q8N8V2
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 GBP7 Homo sapiens Q8N8V2
Y2H Array
32296183
Intra CPNE2 Q96FN4 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra CPNE2 Q96FN4 REL Homo sapiens Q04864
Y2H Array
25416956
Intra CPNE2 Q96FN4 CT55 Homo sapiens Q8WUE5
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 CT55 Homo sapiens Q8WUE5
Y2H Array
32296183
Intra CPNE2 Q96FN4 KATNBL1 Homo sapiens Q9H079
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 KATNBL1 Homo sapiens Q9H079
Validated Y2H
32296183
Intra CPNE2 Q96FN4 KATNBL1 Homo sapiens Q9H079
Y2H Array
32296183
Intra CPNE2 Q96FN4 UBA3 Homo sapiens Q8TBC4
Y2H Prey Pooling
25416956
Intra CPNE2 Q96FN4 UBA3 Homo sapiens Q8TBC4
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 UBA3 Homo sapiens Q8TBC4
Y2H Array
32296183
Intra CPNE2 Q96FN4 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra CPNE2 Q96FN4 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra CPNE2 Q96FN4 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
Intra CPNE2 Q96FN4 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra CPNE2 Q96FN4 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 SORBS3 Homo sapiens O60504
Y2H Array
25416956
Intra CPNE2 Q96FN4 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra CPNE2 Q96FN4 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra CPNE2 Q96FN4 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra CPNE2 Q96FN4 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra CPNE2 Q96FN4 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra CPNE2 Q96FN4 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Mus musculus CPNE2 MGD MGI:2387578
Bos taurus CPNE2 VGNC VGNC:27659
Macaca mulatta CPNE2 VGNC VGNC:71464
Rattus norvegicus CPNE2 RGD RGD:1586036
Canis familiaris CPNE2 VGNC VGNC:39561
Felis catus CPNE2 VGNC VGNC:61129