USP25 - ubiquitin specific peptidase 25 Gene

中文名称：泛素特异性肽酶 25

种属: Homo sapiens

同用名: USP21

基因 ID: 29761 | 基因类型: protein coding

关于 USP25

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:15,729,982-15,880,064 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 20.1), endometrium (RPKM 11.0) and 25 other tissues.

功能概要

泛素 (MIM 191339) 是一种高度保守的 76 氨基酸蛋白，参与调节细胞内蛋白质分解、细胞周期调节和应激反应。泛素通过多泛素链的分解从降解的蛋白质中释放出来，这是由泛素特异性蛋白酶 (USP) 介导的，例如 USP25 (Valero 等人，1999 [PubMed 10644437]) 。[OMIM 提供，2008 年 3 月]

Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]

USP25 基因产物(9)

mRNA	Protein	Name
NM_001283041.3	NP_001269970.1	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25m
NM_001283042.3	NP_001269971.1	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25b
NM_001352560.2	NP_001339489.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 4
NM_001352561.2	NP_001339490.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388299.1	NP_001375228.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 4
NM_001388300.1	NP_001375229.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388301.1	NP_001375230.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388302.1	NP_001375231.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 6
NM_013396.6	NP_037528.3	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATPase binding	IPI IPI: 通过物理相互作用推断	22590560	GOA
enables SUMO binding	IPI IPI: 通过物理相互作用推断	18538659	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: 通过突变表型推断	18538659	GOA
enables deubiquitinase activity	IDA IDA: 通过直接分析推断	23042150	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18538659	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	22590560	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of ERAD pathway	IMP IMP: 通过突变表型推断	22590560	GOA
involved in negative regulation of interleukin-17-mediated signaling pathway	IDA IDA: 通过直接分析推断	23042150	GOA
involved in negative regulation of response to oxidative stress	IDA IDA: 通过直接分析推断	37339955	GOA
involved in protein K48-linked deubiquitination	IMP IMP: 通过突变表型推断	18538659	GOA
involved in protein K63-linked deubiquitination	IMP IMP: 通过突变表型推断	18538659	GOA
involved in protein deubiquitination	IDA IDA: 通过直接分析推断	22590560	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	2304215	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	22590560	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP25 蛋白结构

UIM

UCH

0
200
400
600
800
1000
1055 a.a.

蛋白主名

其他名称

ubiquitin carboxyl-terminal hydrolase 25

USP on chromosome 21

USP25 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	USP25	Q9UHP3	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
种属内	USP25	Q9UHP3	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
种属内	USP25	Q9UHP3	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
种属内	USP25	Q9UHP3	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
种属内	USP25	Q9UHP3	TNKS2	Homo sapiens	Q9H2K2	Y2H Fragment Pooling	35914814
种属内	USP25	Q9UHP3	SUMO2	Homo sapiens	P61956	Y2H Prey Pooling	25416956
种属内	USP25	Q9UHP3	PRKACA	Homo sapiens	P17612	Y2H Array	32814053
种属内	USP25	Q9UHP3	PRKACA	Homo sapiens	P17612	Y2H Pooling	32814053
种属内	USP25	Q9UHP3	PRKACA	Homo sapiens	P17612	Validated Y2H	32814053
种属内	USP25	Q9UHP3	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	25416956
种属内	USP25	Q9UHP3	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	25416956
种属内	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Validated Y2H	32814053
种属内	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Y2H Array	31515488
种属内	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Y2H Array	32814053
种属内	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Y2H Array	25416956
种属内	USP25	Q9UHP3	RAD23A	Homo sapiens	P54725	Y2H Pooling	32814053
种属内	USP25	Q9UHP3	MAGEB4	Homo sapiens	O15481	Validated Y2H	25416956
种属内	USP25	Q9UHP3	SYK	Homo sapiens	P43405	Y2H	21516116
种属内	USP25	Q9UHP3	SYK	Homo sapiens	P43405	Validated Y2H	25416956
种属内	USP25	Q9UHP3	SYK	Homo sapiens	P43405	Y2H Array	25416956
种属内	USP25	Q9UHP3	GDI1	Homo sapiens	P31150	Y2H Fragment Pooling	35914814
种属内	USP25	Q9UHP3	RAD23B	Homo sapiens	P54727	Y2H Fragment Pooling	35914814

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Arthrogryposis, Renal Dysfunction, And Cholestasis 2

ARCS2	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 2
Arthrogryposis Renal Dysfunction And Cholestasis 2

Enterokinase Deficiency

Enteropeptidase Deficiency	Congenital Enterokinase Deficiency
Congenital Enteropathy Due To Enteropeptidase Deficiency	Deficiency Of Enteropeptidase
ENTKD

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-117370	USP25/28 inhibitor AZ1	Inhibitor	≥98.0%	否
HY-153996	CT1113	Inhibitor	/	否
HY-RS15535	USP25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	USP25	RGD	RGD:1309003
Felis catus	USP25	VGNC	VGNC:66875
Mus musculus	USP25	MGD	MGI:1353655
Canis familiaris	USP25	VGNC	VGNC:48184
Bos taurus	USP25	VGNC	VGNC:36718
Macaca mulatta	USP25	VGNC	VGNC:78744
Others	USP25	NCBI

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