1. Gene
  2. SYK - spleen associated tyrosine kinase Gene

SYK - spleen associated tyrosine kinase Gene

中文名称:脾相关酪氨酸激酶

种属: Homo sapiens

同用名: IMD82; p72-Syk

基因 ID: 6850 | 基因类型: protein coding

关于 SYK

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:90,801,600-90,898,549 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues, 32 paralogues and is associated with 82 phenotypes. Broad expression in lymph node (RPKM 32.4), appendix (RPKM 24.8) and 20 other tissues.

功能概要

该基因编码非受体型 Tyr 蛋白激酶家族的成员。这种蛋白质在造血细胞中广泛表达,并参与将激活的免疫受体与下游信号事件偶联,从而介导多种细胞反应,包括增殖、分化和吞噬作用。它被认为是上皮细胞生长的调节剂和人类乳腺癌的潜在肿瘤抑制因子。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2010 年 3 月]

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

SYK 基因产物(9)

mRNA Protein Name
NM_001135052.4 NP_001128524.1 tyrosine-protein kinase SYK isoform Syk(S)
XM_047423810.1 XP_047279766.1 tyrosine-protein kinase SYK isoform X2
XM_047423811.1 XP_047279767.1 tyrosine-protein kinase SYK isoform X3
NM_001174167.3 NP_001167638.1 tyrosine-protein kinase SYK isoform Syk(L)
NM_001174168.3 NP_001167639.1 tyrosine-protein kinase SYK isoform Syk(S)
XM_005252147.5 XP_005252204.1 tyrosine-protein kinase SYK isoform X1
NM_003177.7 NP_003168.2 tyrosine-protein kinase SYK isoform Syk(L)
XM_011518946.4 XP_011517248.1 tyrosine-protein kinase SYK isoform X1
XM_047423809.1 XP_047279765.1 tyrosine-protein kinase SYK isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
12885943 GOA
enables interleukin-15 receptor binding IPI
IPI: 通过物理相互作用推断
15123770 GOA
enables kinase activity IDA
IDA: 通过直接分析推断
9490415 GOA
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
8163536 GOA
enables non-membrane spanning protein tyrosine kinase activity IGI
IGI: 通过遗传相互作用推断
14656219 GOA
enables phospholipase binding IPI
IPI: 通过物理相互作用推断
14656219 GOA
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
20624904 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7761456 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
18818202 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
23071339 GOA
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
8629002 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
34634301 GOA
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
33782605 GOA
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
11606584 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
31145836 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell receptor signaling pathway IMP
IMP: 通过突变表型推断
15509800 GOA
involved in amyloid-beta clearance IDA
IDA: 通过直接分析推断
27477018 GOA
involved in cellular response to amyloid-beta IDA
IDA: 通过直接分析推断
29518356 GOA
involved in cellular response to lipid IMP
IMP: 通过突变表型推断
32514138 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
11606584 GOA
involved in intracellular signal transduction IGI
IGI: 通过遗传相互作用推断
14656219 GOA
involved in intracellular signal transduction IMP
IMP: 通过突变表型推断
32514138 GOA
involved in leukocyte cell-cell adhesion IDA
IDA: 通过直接分析推断
12885943 GOA
involved in neutrophil chemotaxis IDA
IDA: 通过直接分析推断
12885943 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
11606584 GOA
involved in peptidyl-tyrosine phosphorylation IGI
IGI: 通过遗传相互作用推断
14656219 GOA
involved in peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
11606584 GOA
involved in positive regulation of B cell differentiation IMP
IMP: 通过突变表型推断
18369315 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
34634301 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
22267217 GOA
involved in positive regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
19358895 GOA
involved in positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
19358895 GOA
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
19358895 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
25251945 GOA
involved in positive regulation of killing of cells of another organism IMP
IMP: 通过突变表型推断
19358895 GOA
involved in positive regulation of monocyte chemotactic protein-1 production IMP
IMP: 通过突变表型推断
25251945 GOA
involved in positive regulation of protein-containing complex assembly IMP
IMP: 通过突变表型推断
22267217 GOA
involved in positive regulation of superoxide anion generation IMP
IMP: 通过突变表型推断
19358895 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
19358895 GOA
acts upstream of or within protein import into nucleus IMP
IMP: 通过突变表型推断
23071339 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
17681949 GOA
acts upstream of or within regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
23071339 GOA
involved in regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
19151749 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of T cell receptor complex IDA
IDA: 通过直接分析推断
8176201 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23071339 GOA
located in nucleus IDA
IDA: 通过直接分析推断
23071339 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23071339 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SYK 蛋白结构

SH2

SH2: SH2 domain (15 - 92)

SH2

SH2: SH2 domain (168 - 244)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (374 - 623)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 635 a.a.
蛋白主名 其他名称

tyrosine-protein kinase SYK

spleen tyrosine kinase

SYK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SYK P43405 MET Homo sapiens P08581
FPS
24728074
种属内
SYK P43405 CD3E Homo sapiens P07766
SPR
7761456
种属内
SYK P43405 CD3E Homo sapiens P07766 7761456
种属内
SYK P43405 LCK Homo sapiens P06239 8798676
种属内
SYK P43405 LCK Homo sapiens P06239
Y2H
8798676
种属内
SYK P43405 USP25 Homo sapiens Q9UHP3 32296183
种属内
SYK P43405 USP25 Homo sapiens Q9UHP3 32296183
种属内
SYK P43405 USP25 Homo sapiens Q9UHP3 32707033
种属内
SYK P43405 USP25 Homo sapiens Q9UHP3 25416956
种属内
SYK P43405 USP25 Homo sapiens Q9UHP3 32296183
种属内
SYK P43405 EGFR Homo sapiens P00533 16273093
种属内
SYK P43405 CLEC7A Homo sapiens Q9BXN2 31875558
种属内
SYK P43405 FLT3 Homo sapiens P36888 24525236
种属内
SYK P43405 FLT3 Homo sapiens P36888 24525236
种属内
SYK P43405 SH2D2A Homo sapiens Q9NP31 25416956
种属内
SYK P43405 SH2D2A Homo sapiens Q9NP31 25416956
种属内
SYK P43405 SH2D2A Homo sapiens Q9NP31 25416956
种属内
SYK P43405 FCER1G Homo sapiens P30273 9280292
种属内
SYK P43405 FCER1G Homo sapiens P30273 8810294
种属内
SYK P43405 GAB1 Homo sapiens Q13480
FPS
24728074
种属内
SYK P43405 CBL Homo sapiens P22681 15556646
种属内
SYK P43405 STAT3 Homo sapiens P40763 31515488
种属内
SYK P43405 STAT3 Homo sapiens P40763 25416956
种属内
SYK P43405 STAT3 Homo sapiens P40763 32296183
种属内
SYK P43405 STAT3 Homo sapiens P40763 32296183
种属内
SYK P43405 STAT3 Homo sapiens P40763 25416956
种属内
SYK P43405 CD37 Homo sapiens P11049 22624718
种属内
SYK P43405 ERBB2 Homo sapiens P04626 16273093
种属内
SYK P43405 TERF1 Homo sapiens P54274 21044950
种属内
SYK P43405 ERBB3 Homo sapiens P21860 16273093
种属内
SYK P43405 PLCG1 Homo sapiens P19174 8657103
种属内
SYK P43405 TENT5A Homo sapiens Q96IP4 25814554
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Phaeohyphomycosis

Infection By Dematiacious Fungi

Phaehyphomycosis

Phaeomycosis

Pheohyphomycosis

Infection By Dematiacious Fungi [Phaehyphomycosis]

Dematiaceous Fungal Infection

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina

Candidiasis, Vulvovaginal

Candidal Vulvovaginitis

Candidal: Cervix

Monilial Vulvovaginitis

Candidiasis Vulvovaginal

Hematologic Cancer

Hematologic Neoplasm

Hematologic Malignancies

Hematologic Neoplasms

Blood Cancer

Hematologic Malignancy

Hematological Tumors

Hematopoietic And Lymphoid System Tumor

Hematopoietic Cancer

Hematopoietic Neoplasm

Hematopoietic Tumors

Malignant Hematopoietic Neoplasm

Liquid Tumor

Hematopoietic Neoplasms

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Bleeding Disorder, Platelet-Type, 11

BDPLT11

Glycoprotein Vi Deficiency

Gp Vi Deficiency

Platelet-Type Bleeding Disorder 11

Bleeding Diathesis Due To A Collagen Receptor Defect

Bleeding Diathesis Due To Glycoprotein Vi Deficiency

Platelet-Type Bleeding Disorder-11

Bleeding Disorder, Platelet Type 11

Hemorrhage

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia

XLA

Bruton Type Agammaglobulinemia

Bruton'S Agammaglobulinemia

Bruton-Type Agammaglobulinemia

Agmx1

Imd1

Agammaglobulinemia, X-Linked 1

Btk-Deficiency

Agammaglobulinemia

Hypogammaglobulinemia

Agammaglobulinemia, X-Linked, Type 1

Immunodeficiency 1

Bruton Agammaglobulinemia Tyrosine Kinase Deficiency

Bruton'S Agammaglobulinaemia

Bruton'S Sex-Linked Agammaglobulinemia

Bruton'S Type Agammaglobulinemia

Btk Deficiency

Agammaglobulinemia, Btk

Agammaglobulinemia, Bruton Tyrosine Kinase

Congenital Agammaglobulinemia

Immunodeficiency Type 1

X-Linked Agammaglobulinemia Type 1

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Fungal Infectious Disease

Mycoses

Mycosis

Immunodeficiency 82 With Systemic Inflammation

IMD82

Colitis
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency Disease

Primary Immunodeficiency

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Hantavirus Pulmonary Syndrome

Hps

Four Corners Hantavirus

Hards

Hantavirus

Hantavirus-Associated Respiratory Distress Syndrome

Hanta Virus

Hantavirus Cardiopulmonary Syndrome

Hps - [Hantavirus Pulmonary Syndrome]

Hcps - [Hantavirus Cardiopulmonary Syndrome]

Wiskott-Aldrich Syndrome

WAS

Eczema-Thrombocytopenia-Immunodeficiency Syndrome

Immunodeficiency 2

Aldrich Syndrome

Imd2

Wiskott-Aldrich Syndrome 1

Was1

Wiskott Syndrome

Wiskott Aldrich Syndrome

Eczema Thrombocytopenia Immunodeficiency Syndrome

Imd 2

Epidermolysis Bullosa Acquisita

Acquired Epidermolysis Bullosa

Eb Acquisita

Eba

Eba - [Epidermolysis Bullosa Acquisita]

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Fasciitis
Chromoblastomycosis

Chromomycosis

Mossy Foot Disease

Verrucous Dermatitis

Fonseca Disease

Pedroso Disease

Drechslera Hawaiiensis

Drechslera Infection

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Carbapenem Allergy
Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4

AGM4

Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect

B Cell Linker Protein Deficiency

B-Cell Linker Protein Deficiency

Blnk Deficiency

Agammaglobulinemia Autosomal Recessive Due To Blnk Defect

Agammaglobulinemia, Type 4, Autosomal Recessive

Subcutaneous Mycosis

Subcutaneous Fungal Disease

Follicular Lymphoma

Lymphoma, Follicular

Lymphoma Follicular

Brill-Symmers' Disease

Large Cell Follicular Non-Hodgkin Lymphoma

Diffuse Follicle Centre Lymphoma

Diffuse Follicular Lymphoma Nos

Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

Follicular Large Cell Cleaved Or Noncleaved Lymphoma

Large Cell Follicular Noncleaved Lymphoma

Follicular Lymphoma With Or Without Diffuse Areas

Histiocytic Follicular Lymphoma

Histiocytic Nodular Lymphoma

Histiocytic Nodular Malignant Lymphoma

Large Cell Follicular Lymphoma

Large Cell Noncleaved Follicular Lymphoma

Large Cell Noncleaved Follicular Malignant Lymphoma

Nodular Reticulum Cell Sarcoma

Noncleaved Follicular Lymphoma

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Phenytoin Allergy

Dilantin Allergy

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

Autoimmune Glomerulonephritis
Cd45 Deficiency
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Chlorhexidine Allergy
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Thrombocytopenia Due To Platelet Alloimmunization

Immune Thrombocytopenia

Autoimmune Thrombocytopenia

Immune Thrombocytopenic Purpura

Itp

Auto-Immune Thrombocytopenia

Thrombocytopenia Due To Immune Destruction

Autoimmune Thrombocytopenic Purpura

Idiopathic Thrombocytopenic Purpura

Werlhof Disease

Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SYK VGNC VGNC:65876
Mus musculus SYK MGD MGI:99515
Bos taurus SYK VGNC VGNC:35513
Macaca mulatta SYK VGNC VGNC:78063
Canis familiaris SYK VGNC VGNC:47021
Rattus norvegicus SYK RGD RGD:3796
Others SYK NCBI