2. Protein Tyrosine Kinase/RTK GPCR/G Protein Neuronal Signaling
  3. Syk 5-HT Receptor
  4. Syk Inhibitor II dihydrochloride dihydrate

Syk Inhibitor II dihydrochloride dihydrate 

目录号: HY-112390B
产品使用指南

摩尔计算器

Syk Inhibitor II dihydrochloride dihydrate 是一种有效的，高选择性和 ATP 竞争性 Syk 抑制剂，IC50 为 41 nM。Syk Inhibitor II dihydrochloride dihydrate 抑制 RBL 细胞释放 5-HT，IC50 为 460 nM。Syk Inhibitor II dihydrochloride dihydrate 对其他激酶的作用较小，并具有抗过敏作用。

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Syk Inhibitor II dihydrochloride dihydrate Chemical Structure

Syk Inhibitor II dihydrochloride dihydrate Chemical Structure

CAS No. : 1965323-05-0

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Syk Inhibitor II dihydrochloride dihydrate 的其他形式现货产品:

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Syk Inhibitor II dihydrochloride dihydrate 相关抗体

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查看 5-HT Receptor 亚型特异性产品:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect[1].

IC50 & Target[1]

serotonin

460 nM (IC50)

Syk

41 nM (IC50)

PKCε

5.1 μM (IC50)

PKCβ2

11 μM (IC50)

ZAP-70

11.2 μM (IC50)

Btk

15.5 μM (IC50)

Itk

22.6 μM (IC50)

体外研究
(In Vitro)

Syk Inhibitor II (compound 9a) dihydrochloride dihydrate shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC50 values of 5.1 µM, 11 µM, 11.2 µM, 15.5 µM, and 22.6 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Syk Inhibitor II dihydrochloride dihydrate 相关抗体:
体内研究
(In Vivo)

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride dihydrate is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

449.26

Formula

C14H21Cl2F3N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Syk Inhibitor II dihydrochloride dihydrate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Syk Inhibitor II dihydrochloride dihydrate1965323-05-0Syk5-HT ReceptorSpleen tyrosine kinaseSerotonin Receptor5-hydroxytryptamine ReceptorAnti-allergicATP-competitivepyrimidine-carboxamideantigenInhibitorinhibitorinhibit

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