2. Protein Tyrosine Kinase/RTK Autophagy Apoptosis Metabolic Enzyme/Protease
  3. Syk Autophagy Apoptosis Endogenous Metabolite
  4. Piceatannol

Piceatannol  (Synonyms: 白皮杉醇; Astringenin; trans-Piceatannol)

目录号: HY-13518 纯度: 98.90%
COA 产品使用指南

摩尔计算器

Piceatannol 是一种 Syk 抑制剂，可降低由 TNF 诱导的 iNOS 表达。 Piceatannol 可用于急性肺损伤 (ALI)的研究。Piceatannol 是一种天然存在的多酚二苯乙烯，存在于各种水果和蔬菜中，具有抗癌和抗炎特性。Piceatannol 在 DLBCL 细胞系中诱导细胞凋亡(apoptosis)。Piceatannol 在 MOLT-4 人白血病细胞中诱导自噬 (autophagy) 和凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Piceatannol Chemical Structure

Piceatannol Chemical Structure

CAS No. : 10083-24-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥726
In-stock
1 mg ￥206
In-stock
5 mg ￥412
In-stock
10 mg ￥660
In-stock
25 mg ￥1120
In-stock
50 mg ￥1570
In-stock
100 mg ￥2230
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Piceatannol:

Piceatannol 相关抗体

Top Publications Citing Use of Products

    Piceatannol purchased from MCE. Usage Cited in: Cell. 2018 Oct 4;175(2):442-457.e23.  [Abstract]

    Syk inhibitors (R406 and Piceatannol) are added during the induction of trastuzumab-dependent BT-474 phagocytosis. The binding of the phagosome marker Rab7 to AIM2 in macrophages are evaluated by co-immunoprecipitation.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI)[1]. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties[2]. Piceatannol induces apoptosis in DLBCL cell lines[3]. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells[4].

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A2780 IC50
    41 μM
    Compound: 4
    Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
    Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay
    		[PMID: 24239390]
    BV-2 IC50
    80.51 μM
    Compound: 29
    Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
    Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
    		[PMID: 28911817]
    J774 IC50
    13 μM
    Compound: 5
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA
    		[PMID: 29726680]
    J774 IC50
    2.6 μM
    Compound: 5
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 29726680]
    J774 IC50
    4 μM
    Compound: 5
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
    		[PMID: 29726680]
    NCI-H522 EC50
    17 μM
    Compound: Piceatannol
    Antiproliferative activity against human NCI-H522 cells after 72 hrs by WST8 assay
    Antiproliferative activity against human NCI-H522 cells after 72 hrs by WST8 assay
    		[PMID: 28169168]
    NCI-H522 EC50
    23 μM
    Compound: Piceatannol
    Antiproliferative activity against human NCI-H522 cells after 48 hrs by WST8 assay
    Antiproliferative activity against human NCI-H522 cells after 48 hrs by WST8 assay
    		[PMID: 28169168]
    NCI-H522 EC50
    53 μM
    Compound: Piceatannol
    Antiproliferative activity against human NCI-H522 cells after 24 hrs by WST8 assay
    Antiproliferative activity against human NCI-H522 cells after 24 hrs by WST8 assay
    		[PMID: 28169168]
    U373-MAGI EC50
    21.4 μM
    Compound: 1b
    Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
    Antiviral activity against HIV1 infected in human U373-MAGI cells expressing CXCR4 assessed as inhibition of viral infection preincubated for 2 hrs prior to infection followed by compound wash out measured after 48 hrs by single round replication assay
    		[PMID: 23010273]
    体外研究
    (In Vitro)

    Piceatannol is a resveratrol metabolite[2].
    SYK inhibitor Piceatannol (3.125, 6.25, 12.5, 25, and 50 μM; 72 hours) inhibits cell growth of six diffuse large B cell lymphomas (DLBCL) cell lines (SUDHL-6, U2392,DOHH2,Karpas 422, VAL, OCI Ly19) with IC50s of 18 μM, 25 μM, 37 μM, 48 μM, >50 μM and >50 μM, respectively[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Piceatannol 相关抗体:

    Cell Cytotoxicity Assay[3]

    Cell Line: Six DLBCL cell lines (Karpas 422, VAL, SUDHL-6, OCI Ly19, U2392 and DOHH2)
    Concentration: 3.125, 6.25, 12.5, 25, and 50 μM
    Incubation Time: 72 hours
    Result: The IC50s were 18 μM in SUDHL-6, 25 μM in U2392, 37 mM in DOHH2, 48 μM in Karpas 422 and higher than 50 μM in OCI-Ly19 and in VAL.
    体内研究
    (In Vivo)

    Piceatannol (10, 20, and 40 mg/kg) inhibits the pulmonary edema and? reduces the infiltration of inflammatory cells induced by lipopolysaccharide[1].
    Piceatannol (10, 20, and 40 mg/kg) alleviates the myeloperoxidase activity and? inhibits the production of iNOS and COX-2 expressions in lung tissuesinduced by lipopolysaccharide[1].
    Piceatannol (10, 20, and 40 mg/kg; intraperitoneally 1 h) treatment alleviates inflammatory response by inhibiting the activation of TLR/NF-κB signaling pathway in lung tissues during acute lung injury (ALI) induced by LPS[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice (40-50 g)[1]
    Dosage: 10, 20, and 40 mg/kg
    Administration: Intraperitoneally 1 h before LPS challenge
    Result: Significantly reduced the pulmonary edema induced by LPS.
    分子量

    244.24

    Formula

    C14H12O4
    CAS 号
    性状

    固体

    颜色

    Light yellow to khaki

    中文名称

    白皮杉醇
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 97.47 mg/mL (399.07 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 4.0943 mL 20.4717 mL 40.9433 mL
    5 mM 0.8189 mL 4.0943 mL 8.1887 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    请根据您的 实验动物和给药方式 选择适当的溶解方案。

    以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
    以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 方案 一

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (10.24 mM); 澄清溶液

      此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

      生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
    • 方案 二

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (10.24 mM); 澄清溶液

      此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

      2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    请输入您的动物体内配方组成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
    方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
    计算结果
    工作液所需浓度 : mg/mL
    储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
    您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
    动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
    连续给药周期超过半月以上，请谨慎选择该方案。
    请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
    纯度 & 产品资料
    参考文献

    Piceatannol 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.0943 mL 20.4717 mL 40.9433 mL 102.3583 mL
    5 mM 0.8189 mL 4.0943 mL 8.1887 mL 20.4717 mL
    10 mM 0.4094 mL 2.0472 mL 4.0943 mL 10.2358 mL
    15 mM 0.2730 mL 1.3648 mL 2.7296 mL 6.8239 mL
    20 mM 0.2047 mL 1.0236 mL 2.0472 mL 5.1179 mL
    25 mM 0.1638 mL 0.8189 mL 1.6377 mL 4.0943 mL
    30 mM 0.1365 mL 0.6824 mL 1.3648 mL 3.4119 mL
    40 mM 0.1024 mL 0.5118 mL 1.0236 mL 2.5590 mL
    50 mM 0.0819 mL 0.4094 mL 0.8189 mL 2.0472 mL
    60 mM 0.0682 mL 0.3412 mL 0.6824 mL 1.7060 mL
    80 mM 0.0512 mL 0.2559 mL 0.5118 mL 1.2795 mL
    100 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0236 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Piceatannol10083-24-6Astringenin trans-Piceatannol白皮杉醇SykAutophagyApoptosisEndogenous MetaboliteSpleen tyrosine kinaseiNOSacutelunginjuryALIanticanceranti-inflammatoryInhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    Piceatannol
    目录号：
    HY-13518
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z