SUMO2 - small ubiquitin like modifier 2 Gene

中文名称：小泛素样修饰符 2

种属: Homo sapiens

同用名: HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2

关于 SUMO2

功能概要

该基因编码的蛋白质是 SUMO (小泛素样修饰剂) 蛋白质家族的成员。它以类似于泛素的方式发挥作用，因为它作为翻译后修饰系统的一部分与目标蛋白质结合。然而，与靶向蛋白质降解的泛素不同，该蛋白质参与多种细胞过程，例如核转运、转录调节、细胞凋亡和蛋白质稳定性。直到羧基末端的最后两个氨基酸被切除后，它才具有活性。已经报道了该基因的许多假基因。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, Apoptosis, and protein stability. It is not active until the last two Amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]