2. Gene
  3. PELP1 - proline, glutamate and leucine rich protein 1 Gene

PELP1 - proline, glutamate and leucine rich protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富脯氨酸、谷氨酸和亮氨酸的蛋白质 1

种属: Homo sapiens

同用名: MNAR; P160

基因 ID: 27043 | 基因类型: protein coding

关于 PELP1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,669,774-4,704,137 (from NCBI)

This gene has 15 transcripts (splice variants) and 110 orthologues. Ubiquitous expression in testis (RPKM 17.1), brain (RPKM 10.6) and 25 other tissues.

功能概要

该基因编码一种转录因子，该转录因子共同激活雌激素受体反应基因的转录，并共同抑制由其他激素受体或序列特异性转录因子激活的基因。该基因的表达受雌激素受体家族的两个成员调节。该基因可能参与多种癌症的进展。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 5 月]

This gene encodes a transcription factor which coactivates transcription of Estrogen Receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the Estrogen Receptor family. This gene may be involved in the progression of several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

PELP1 基因产物(2)

mRNA Protein Name
NM_001278241.2 NP_001265170.1 proline-, glutamic acid- and leucine-rich protein 1 isoform 2
NM_014389.3 NP_055204.4 proline-, glutamic acid- and leucine-rich protein 1 isoform 1

PELP1 蛋白结构

RIX1

RIX1: rRNA processing/ribosome biogenesis (73 - 224)

NUC202

NUC202: NUC202 domain (423 - 488)

NUC202

NUC202: NUC202 domain (569 - 639)

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  • 1130 a.a.
蛋白主名 其他名称

proline-, glutamic acid- and leucine-rich protein 1

modulator of non-genomic activity of estrogen receptor

关联疾病

疾病名称 别名
Brain Oligodendroglioma

Oligodendroglioma Of Brain
Brain Ependymoma

Ependymal Tumor Of Brain

Ependymoma Of Brain
Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Teeth Hard Tissue Disease
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10324 PELP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-159613 SMIP34 Inducer / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PELP1 VGNC VGNC:64111
Mus musculus PELP1 MGD MGI:1922523
Macaca mulatta PELP1 VGNC VGNC:75894
Rattus norvegicus PELP1 RGD RGD:1306320
Canis familiaris PELP1 VGNC VGNC:44417
Bos taurus PELP1 VGNC VGNC:32744
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