PELP1 - proline, glutamate and leucine rich protein 1 Gene

中文名称：富脯氨酸、谷氨酸和亮氨酸的蛋白质 1

种属: Homo sapiens

同用名: MNAR; P160

基因 ID: 27043 | 基因类型: protein coding

关于 PELP1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,669,774-4,704,137 (from NCBI)

This gene has 15 transcripts (splice variants) and 110 orthologues. Ubiquitous expression in testis (RPKM 17.1), brain (RPKM 10.6) and 25 other tissues.

功能概要

该基因编码一种转录因子，该转录因子共同激活雌激素受体反应基因的转录，并共同抑制由其他激素受体或序列特异性转录因子激活的基因。该基因的表达受雌激素受体家族的两个成员调节。该基因可能参与多种癌症的进展。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 5 月]

This gene encodes a transcription factor which coactivates transcription of Estrogen Receptor responsive genes and corepresses genes activated by Other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the Estrogen Receptor family. This gene may be involved in the progression of several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

PELP1 基因产物(2)

mRNA	Protein	Name
NM_001278241.2	NP_001265170.1	proline-, glutamic acid- and leucine-rich protein 1 isoform 2
NM_014389.3	NP_055204.4	proline-, glutamic acid- and leucine-rich protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SUMO binding	IMP IMP: 通过突变表型推断	27814492	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	17505058	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16169070	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to estrogen stimulus	IDA IDA: 通过直接分析推断	17505058	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17505058	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MLL1 complex	IDA IDA: 通过直接分析推断	15960975	GOA
located in euchromatin	IDA IDA: 通过直接分析推断	17505058	GOA
located in nucleus	IDA IDA: 通过直接分析推断	27814492	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PELP1 蛋白结构

RIX1

NUC202

0
200
400
600
800
1000
1130 a.a.

蛋白主名

其他名称

proline-, glutamic acid- and leucine-rich protein 1

modulator of non-genomic activity of estrogen receptor

PELP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PELP1	Q8IZL8	MDN1	Homo sapiens	Q9NU22	Anti Tag CoIP	21326211
种属内	PELP1	Q8IZL8	MDN1	Homo sapiens	Q9NU22	Pull Down	21326211
种属内	PELP1	Q8IZL8	H3-3A	Homo sapiens	P84243	Anti Bait CoIP	20448663
种属内	PELP1	Q8IZL8	H3-3A	Homo sapiens	P84243	Pull Down	20448663
种属内	PELP1	Q8IZL8	TEX10	Homo sapiens	Q9NXF1	Crosslink	36351913
种属内	PELP1	Q8IZL8	TEX10	Homo sapiens	Q9NXF1	Anti Tag CoIP	36351913
种属内	PELP1	Q8IZL8	SENP3	Homo sapiens	Q9H4L4	IF	21326211
种属内	PELP1	Q8IZL8	SENP3	Homo sapiens	Q9H4L4	Anti Tag CoIP	36351913
种属内	PELP1	Q8IZL8	SENP3	Homo sapiens	Q9H4L4	Crosslink	36351913
种属内	PELP1	Q8IZL8	NFKB1	Homo sapiens	P19838	TAP	20195357
种属内	PELP1	Q8IZL8	NFKB1	Homo sapiens	P19838	Display Tech	20195357
种属内	PELP1	Q8IZL8	SUMO2	Homo sapiens	P61956	Y2H Pooling	16169070
种属内	PELP1	Q8IZL8	KDM1A	Homo sapiens	O60341	Pull Down	20448663
种属内	PELP1	Q8IZL8	KDM1A	Homo sapiens	O60341	Anti Bait CoIP	20448663
种属内	PELP1	Q8IZL8	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	20448663
种属内	PELP1	Q8IZL8	WDR18	Homo sapiens	Q9BV38	Anti Tag CoIP	21326211
种属内	PELP1	Q8IZL8	WDR18	Homo sapiens	Q9BV38	Anti Tag CoIP	36351913
种属内	PELP1	Q8IZL8	WDR18	Homo sapiens	Q9BV38	3D-EM	36351913
种属内	PELP1	Q8IZL8	WDR18	Homo sapiens	Q9BV38	Anti Bait CoIP	36351913
种属内	PELP1	Q8IZL8	WDR18	Homo sapiens	Q9BV38	Anti Bait CoIP	21326211
种属内	PELP1	Q8IZL8	WDR18	Homo sapiens	Q9BV38	Crosslink	36351913
种属内	PELP1	Q8IZL8	NPM1	Homo sapiens	P06748	Anti Bait CoIP	21326211

种属间: 跨种属相互作用 种属内: 同种属相互作用

PELP1 抗体

目录号	产品名	应用	反应物种
HY-P83217	PELP1 Antibody (YA2962)	WB, IHC-P, ICC/IF, FC	Human

关联疾病

疾病名称

别名

Brain Oligodendroglioma

Oligodendroglioma Of Brain

Brain Ependymoma

Ependymal Tumor Of Brain

Ependymoma Of Brain

Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome	Ers
Amelogenesis Imperfecta Type 1g	AI1G
Enamel-Renal-Gingival Syndrome	Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome
Aigfs	Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis
Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis	Amelogenesis Imperfecta Type Ig
Amelogenesis Imperfecta-Nephrocalcinosis Syndrome	Amelogenesis Imperfecta 1g
Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis	Amelogenesis Imperfecta Nephrocalcinosis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Teeth Hard Tissue Disease

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10324	PELP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-159613	PELP1-IN-1	Inducer	98.99%	否
HY-169903	SMIP34	Inducer	≥90.0%	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PELP1	VGNC	VGNC:64111
Mus musculus	PELP1	MGD	MGI:1922523
Macaca mulatta	PELP1	VGNC	VGNC:75894
Rattus norvegicus	PELP1	RGD	RGD:1306320
Canis familiaris	PELP1	VGNC	VGNC:44417
Bos taurus	PELP1	VGNC	VGNC:32744

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PELP1 - proline, glutamate and leucine rich protein 1 Gene

关于 PELP1

功能概要

PELP1 基因产物(2)

PELP1 蛋白结构

PELP1 蛋白互作信息

PELP1 抗体

关联疾病

直系同源

热门区域

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PELP1 - proline, glutamate and leucine rich protein 1 Gene

关于 PELP1

功能概要

PELP1 基因产物(2)

PELP1 蛋白结构

PELP1 蛋白互作信息

PELP1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z