SENP3 - SUMO specific peptidase 3 Gene

中文名称：SUMO 特异性肽酶 3

种属: Homo sapiens

同用名: SSP3; Ulp1; SMT3IP1

关于 SENP3

功能概要

许多生物过程都需要通过添加小泛素样 SUMO 蛋白 (参见 SUMO1；MIM 601912) 对蛋白质进行可逆的翻译后修饰。 SUMO 特异性蛋白酶，如 SENP3，负责 SUMO 前体的初始加工，以生成结合反应所需的 C 末端二甘氨酸基序。它们还具有异肽酶活性，可从高分子量 SUMO 结合物中去除 SUMO (Di Bacco 等人，2006 [PubMed 16738315]) 。[OMIM 提供，2009 年 6 月]

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]