ZBTB33 - zinc finger and BTB domain containing 33 Gene

中文名称：含锌指和 BTB 域 33

种属: Homo sapiens

同用名: ZNF348; ZNF-kaiso

关于 ZBTB33

功能概要

该基因编码具有双峰 DNA 结合特异性的转录调节因子，它结合甲基化的 CGCG 和非甲基化的共有 KAISO 结合位点 TCCTGCNA。该蛋白质包含一个 N 端 POZ/BTB 结构域和 3 个 C 端锌指基序。它募集 N-CoR 阻遏物复合物以促进组蛋白去乙酰化和靶基因启动子中抑制染色质结构的形成。它可能有助于抑制 Wnt 信号通路的靶基因，也可能通过募集连环蛋白 delta-2 (CTNND2) 激活靶基因子集的转录。它与连环蛋白 delta-1 (CTNND1) 的相互作用抑制与甲基化和非甲基化 DNA 的结合。它还直接与核输入受体 Importin-#945;2 (也称为 karyopherin alpha2 或 RAG 队列 1) 相互作用，这可能介导该蛋白质的核输入。已经鉴定出编码相同蛋白质的可变剪接转录本变体。[RefSeq 提供，2010 年 5 月]

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]