PIAS4 - protein inhibitor of activated STAT 4 Gene

中文名称：活化 STAT 4 蛋白抑制因子

种属: Homo sapiens

同用名: PIASY; Piasg; ZMIZ6; PIAS-gamma

基因 ID: 51588 | 基因类型: protein coding

关于 PIAS4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,007,736-4,039,386 (from NCBI)

This gene has 6 transcripts (splice variants), 222 orthologues and 5 paralogues. Broad expression in testis (RPKM 14.8), spleen (RPKM 3.8) and 25 other tissues.

功能概要

启用 SUMO 连接酶活性和泛素蛋白连接酶结合活性。参与转录的负调控，以 DNA 为模板；蛋白质苏木化的正调控；和蛋白质苏木化。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables SUMO Ligase activity and ubiquitin protein Ligase binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of protein sumoylation; and protein sumoylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PIAS4 基因产物(1)

mRNA	Protein	Name
NM_015897.4	NP_056981.2	E3 SUMO-protein ligase PIAS4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SUMO ligase activity	IDA IDA: 通过直接分析推断	18579533	GOA
enables SUMO transferase activity	EXP EXP: 通过实验结果推断	11731474	GOA
enables SUMO transferase activity	IMP IMP: 通过突变表型推断	22508508	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11388671	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	16816390	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11248056	GOA
involved in negative regulation of protein localization to chromatin	IDA IDA: 通过直接分析推断	35013556	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	32832608	GOA
involved in positive regulation of protein sumoylation	IDA IDA: 通过直接分析推断	17696781	GOA
involved in protein sumoylation	IDA IDA: 通过直接分析推断	18579533	GOA
involved in protein sumoylation	IMP IMP: 通过突变表型推断	22508508	GOA
involved in regulation of mRNA stability	IDA IDA: 通过直接分析推断	34048572	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16816390	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11248056	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIAS4 蛋白结构

PINIT

zf-MIZ

0
100
200
300
400
510 a.a.

蛋白主名

其他名称

E3 SUMO-protein ligase PIAS4

RING-type E3 ubiquitin transferase PIAS4

PIAS4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PIAS4	Q8N2W9	WBP1L	Homo sapiens	Q9NX94	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	WBP1L	Homo sapiens	Q9NX94	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	WBP1L	Homo sapiens	Q9NX94	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	LARP4B	Homo sapiens	Q92615	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	LARP4B	Homo sapiens	Q92615	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	LARP4B	Homo sapiens	Q92615	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	MAGEC3	Homo sapiens	Q8TD91-2	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	MAGEC3	Homo sapiens	Q8TD91-2	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	MAGEC3	Homo sapiens	Q8TD91-2	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	ZBTB34	Homo sapiens	Q8NCN2	Validated Y2H	32296183
Intra	PIAS4	Q8N2W9	SPATA24	Homo sapiens	Q86W54-2	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	SPATA24	Homo sapiens	Q86W54-2	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	SPATA24	Homo sapiens	Q86W54-2	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	IFI35	Homo sapiens	P80217-2	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	IFI35	Homo sapiens	P80217-2	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	IFI35	Homo sapiens	P80217-2	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	ZMYM6	Homo sapiens	O95789-4	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	ZMYM6	Homo sapiens	O95789-4	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	ZMYM6	Homo sapiens	O95789-4	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	BOD1	Homo sapiens	Q96IK1-2	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	BOD1	Homo sapiens	Q96IK1-2	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	BOD1	Homo sapiens	Q96IK1-2	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	TOP2B	Homo sapiens	Q02880	Anti Tag CoIP	33961781
Intra	PIAS4	Q8N2W9	AHCYL1	Homo sapiens	O43865	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	AHCYL1	Homo sapiens	O43865	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	AHCYL1	Homo sapiens	O43865	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	GALNT10	Homo sapiens	F2Z2M7	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	GALNT10	Homo sapiens	F2Z2M7	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	GALNT10	Homo sapiens	F2Z2M7	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	CAMKK1	Homo sapiens	Q8N5S9-2	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	CAMKK1	Homo sapiens	Q8N5S9-2	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	CAMKK1	Homo sapiens	Q8N5S9-2	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	ITGB1BP2	Homo sapiens	Q9UKP3-2	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	ITGB1BP2	Homo sapiens	Q9UKP3-2	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	ITGB1BP2	Homo sapiens	Q9UKP3-2	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	KLF15	Homo sapiens	Q9UIH9	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	CRLF3	Homo sapiens	Q8IUI8	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	CRLF3	Homo sapiens	Q8IUI8	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	CRLF3	Homo sapiens	Q8IUI8	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	MTNAP1	Homo sapiens	Q9BSJ5	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	MTNAP1	Homo sapiens	Q9BSJ5	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	MTNAP1	Homo sapiens	Q9BSJ5	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	GPSM3	Homo sapiens	Q9Y4H4	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	GPSM3	Homo sapiens	Q9Y4H4	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	PARP1	Homo sapiens	P09874	Pull Down	19779455
Intra	PIAS4	Q8N2W9	PARP1	Homo sapiens	P09874	Anti Bait CoIP	19779455
Intra	PIAS4	Q8N2W9	SMARCD1	Homo sapiens	Q96GM5	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	SMARCD1	Homo sapiens	Q96GM5	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	ESRRA	Homo sapiens	P11474	Y2H	21988832
Intra	PIAS4	Q8N2W9	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	FAM117B	Homo sapiens	Q6P1L5	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	FAM117B	Homo sapiens	Q6P1L5	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	NMT2	Homo sapiens	O60551	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	NMT2	Homo sapiens	O60551	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	NMT2	Homo sapiens	O60551	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	HOXC4	Homo sapiens	P09017	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	HOXC4	Homo sapiens	P09017	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	HOXC4	Homo sapiens	P09017	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	ELL2	Homo sapiens	O00472	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	ELL2	Homo sapiens	O00472	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	ELL2	Homo sapiens	O00472	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	20661221
Intra	PIAS4	Q8N2W9	HTT	Homo sapiens	P42858	Y2H	15383276
Intra	PIAS4	Q8N2W9	HTT	Homo sapiens	P42858	Pull Down	15383276
Intra	PIAS4	Q8N2W9	SUMO2	Homo sapiens	P61956	Y2H	15383276
Intra	PIAS4	Q8N2W9	TADA3	Homo sapiens	O75528	Anti Tag CoIP	33961781
Intra	PIAS4	Q8N2W9	CCDC141	Homo sapiens	Q6ZP82-1	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	CCDC141	Homo sapiens	Q6ZP82-1	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	CCDC141	Homo sapiens	Q6ZP82-1	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	LPIN1	Homo sapiens	Q14693	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	LPIN1	Homo sapiens	Q14693	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	LPIN1	Homo sapiens	Q14693	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	SAP30	Homo sapiens	O75446	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	SAP30	Homo sapiens	O75446	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	SAP30	Homo sapiens	O75446	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	RELA	Homo sapiens	Q04206	Anti Bait CoIP	17606919
Intra	PIAS4	Q8N2W9	RELA	Homo sapiens	Q04206	Anti Tag CoIP	17606919
Intra	PIAS4	Q8N2W9	RBM11	Homo sapiens	P57052	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	RBM11	Homo sapiens	P57052	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	RBM11	Homo sapiens	P57052	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	KCTD13	Homo sapiens	Q8WZ19	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	KCTD13	Homo sapiens	Q8WZ19	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	KCTD13	Homo sapiens	Q8WZ19	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	MYOZ1	Homo sapiens	Q9NP98	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	MYOZ1	Homo sapiens	Q9NP98	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	GABPB2	Homo sapiens	Q8TAK5	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	GABPB2	Homo sapiens	Q8TAK5	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	GABPB2	Homo sapiens	Q8TAK5	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	GATA1	Homo sapiens	P15976-2	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	GATA1	Homo sapiens	P15976-2	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	GATA1	Homo sapiens	P15976-2	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	SHOX2	Homo sapiens	O60902-3	Y2H Pooling	32814053
Intra	PIAS4	Q8N2W9	SHOX2	Homo sapiens	O60902-3	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	SHOX2	Homo sapiens	O60902-3	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	PIAS4	Q8N2W9	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	PIAS4	Q8N2W9	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h

Lgmd2h	Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency
Muscular Dystrophy Hutterite Type	Sarcotubular Myopathy
Limb-Girdle Muscular Dystrophy Type 2h

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10476	PIAS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PIAS4	VGNC	VGNC:75813
Felis catus	PIAS4	VGNC	VGNC:80653
Rattus norvegicus	PIAS4	RGD	RGD:1308737
Canis familiaris	PIAS4	VGNC	VGNC:44522
Mus musculus	PIAS4	MGD	MGI:2136940
Bos taurus	PIAS4	VGNC	VGNC:32858

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