SAP30 - Sin3A associated protein 30 Gene

中文名称：Sin3A 相关蛋白 30

种属: Homo sapiens

关于 SAP30

功能概要

组蛋白乙酰化在真核基因表达的调控中起着关键作用。组蛋白乙酰化和脱乙酰化由多亚基复合物催化。该基因编码的蛋白质是组蛋白脱乙酰酶复合物的组成部分，包括 SIN3、SAP18、HDAC1、HDAC2、RbAp46、RbAp48 等多肽。该复合物对核心组蛋白八聚体去乙酰化具有活性，但对核小体组蛋白去乙酰化无活性。该基因的假基因位于 3 号染色体上。[RefSeq 提供，2008 年 7 月]

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]