KCTD13 - potassium channel tetramerization domain containing 13 Gene

中文名称：含钾通道四聚结构域 13

种属: Homo sapiens

同用名: PDIP1; FKSG86; BACURD1; POLDIP1; hBACURD1

基因 ID: 253980 | 基因类型: protein coding

关于 KCTD13

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,906,339-29,926,226 (from NCBI)

This gene has 12 transcripts (splice variants), 218 orthologues and 2 paralogues. Broad expression in testis (RPKM 12.8), brain (RPKM 4.9) and 23 other tissues.

功能概要

实现相同的蛋白质结合活性和小 GTP 酶结合活性。有助于泛素蛋白转移酶活性。参与多个过程，包括细胞蛋白质代谢过程； Rho 蛋白信号转导的负调控；和应力纤维组件。位于核体。 Cul3-RING 泛素连接酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of Rho protein signal transduction; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

KCTD13 基因产物(2)

mRNA	Protein	Name
NM_001410898.1	NP_001397827.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 2
NM_178863.5	NP_849194.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables small GTPase binding	IDA IDA: 通过直接分析推断	19782033	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	19782033	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell migration	IMP IMP: 通过突变表型推断	19782033	GOA
involved in negative regulation of Rho protein signal transduction	IMP IMP: 通过突变表型推断	19782033	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	19782033	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	19782033	GOA
involved in stress fiber assembly	IMP IMP: 通过突变表型推断	19782033	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Cul3-RING ubiquitin ligase complex	IDA IDA: 通过直接分析推断	19782033	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCTD13 蛋白结构

BTB_2

0
100
200
300
329 a.a.

蛋白主名

其他名称

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

BTB/POZ domain-containing protein KCTD13

KCTD13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	KCTD13	Q8WZ19	MAT2A	Homo sapiens	P31153	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	MAT2A	Homo sapiens	P31153	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	MAT2A	Homo sapiens	P31153	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Anti Tag CoIP	33961781
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Anti Tag CoIP	28514442
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	25416956
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	32296183
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Y2H Array	25416956
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Anti Tag CoIP	19615732
Intra	KCTD13	Q8WZ19	TNFAIP1	Homo sapiens	Q13829	Y2H Array	32296183
Intra	KCTD13	Q8WZ19	KCTD10	Homo sapiens	Q9H3F6	Anti Tag CoIP	33961781
Intra	KCTD13	Q8WZ19	KCTD10	Homo sapiens	Q9H3F6	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	KCTD10	Homo sapiens	Q9H3F6	Anti Tag CoIP	19615732
Intra	KCTD13	Q8WZ19	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	CUL3	Homo sapiens	Q13618	Validated Y2H	25416956
Intra	KCTD13	Q8WZ19	CUL3	Homo sapiens	Q13618	Y2H Array	25416956
Intra	KCTD13	Q8WZ19	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	33961781
Intra	KCTD13	Q8WZ19	FXR1	Homo sapiens	P51114	Anti Tag CoIP	21653829
Intra	KCTD13	Q8WZ19	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	KCTD13	Q8WZ19	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	KCTD13	Q8WZ19	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	KCTD13	Q8WZ19	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	KCTD13	Q8WZ19	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	25416956
Intra	KCTD13	Q8WZ19	ZMYND19	Homo sapiens	Q96E35	Y2H Prey Pooling	25416956
Intra	KCTD13	Q8WZ19	BAG3	Homo sapiens	O95817	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	BAG3	Homo sapiens	O95817	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	BAG3	Homo sapiens	O95817	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	KCTD13	Q8WZ19	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	KCTD13	Q8WZ19	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	KCTD13	Q8WZ19	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Scalp-Ear-Nipple Syndrome

Finlay-Marks Syndrome	Sen Syndrome
SENS	Scalp Ear Nipple Syndrome
Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples	Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples
Indian Childhood Cirrhosis

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07190	KCTD13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	KCTD13	RGD	RGD:735189
Mus musculus	KCTD13	MGD	MGI:1923739
Macaca mulatta	KCTD13	VGNC	VGNC:104735
Bos taurus	KCTD13	VGNC	VGNC:30503
Canis familiaris	KCTD13	VGNC	VGNC:42302
Felis catus	KCTD13	VGNC	VGNC:63054

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