2. Gene
  3. KCTD10 - potassium channel tetramerization domain containing 10 Gene

KCTD10 - potassium channel tetramerization domain containing 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含钾通道四聚结构域 10

种属: Homo sapiens

同用名: BTBD28; ULRO61; MSTP028; hBACURD3

基因 ID: 83892 | 基因类型: protein coding

关于 KCTD10

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,448,655-109,477,300 (from NCBI)

This gene has 16 transcripts (splice variants), 251 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 26.1), endometrium (RPKM 18.7) and 24 other tissues.

功能概要

该基因编码的蛋白质与增殖细胞核抗原 (PCNA) 结合，可能参与 DNA 合成和细胞增殖。此外，编码的蛋白质可能是肿瘤抑制因子。已发现该基因的几种蛋白质编码和非蛋白质编码转录物变体。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

KCTD10 基因产物(3)

mRNA Protein Name
NM_001317395.2 NP_001304324.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1
NM_001317399.2 NP_001304328.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 3
NM_031954.5 NP_114160.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IPI
IPI: 通过物理相互作用推断
25401743 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19615732 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
25401743 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCTD10 蛋白结构

BTB_2

BTB_2: BTB/POZ domain (34 - 124)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

BTB/POZ domain-containing protein KCTD10

KCTD10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KCTD10 Q9H3F6 TEX11 Homo sapiens Q8IYF3-3
Y2H Prey Pooling
32296183
种属内
KCTD10 Q9H3F6 TEX11 Homo sapiens Q8IYF3-3
Y2H Array
32296183
种属内
KCTD10 Q9H3F6 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
32296183
种属内
KCTD10 Q9H3F6 TNFAIP1 Homo sapiens Q13829
Y2H Array
32296183
种属内
KCTD10 Q9H3F6 KCTD13 Homo sapiens Q8WZ19
Y2H Prey Pooling
32296183
种属内
KCTD10 Q9H3F6 KCTD13 Homo sapiens Q8WZ19
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Methylmalonic Aciduria, Cblb Type

Methylmalonic Aciduria Cblb Type

Methylmalonic Acidemia Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type

Methylmalonic Acidemia, Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type

Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type

Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb

Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb

Methylmalonic Aciduria Type Cblb

MMAB

Methylmalonic Aciduria Type B

Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B

Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B

Aciduria, Methylmalonic, Cblb Type

Methylmalonic Acidemia

Methylmalonic Aciduria
Scalp-Ear-Nipple Syndrome

Finlay-Marks Syndrome

Sen Syndrome

SENS

Scalp Ear Nipple Syndrome

Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples

Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples

Indian Childhood Cirrhosis
Branchiooculofacial Syndrome

Branchio-Oculo-Facial Syndrome

BOFS

Bof Syndrome

Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome

Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome

Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging

Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging

Bofs Syndrome

Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07187 KCTD10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta KCTD10 VGNC VGNC:73893
Felis catus KCTD10 VGNC VGNC:63053
Canis familiaris KCTD10 VGNC VGNC:42300
Mus musculus KCTD10 MGD MGI:2141207
Rattus norvegicus KCTD10 RGD RGD:1591979
Bos taurus KCTD10 VGNC VGNC:30500
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