MAT2A - methionine adenosyltransferase 2A Gene

中文名称：甲硫氨酸腺苷转移酶 2A

种属: Homo sapiens

同用名: MATA2; MATII; SAMS2

基因 ID: 4144 | 基因类型: protein coding

关于 MAT2A

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,539,168-85,545,281 (from NCBI)

This gene has 6 transcripts (splice variants), 292 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 234.0), adrenal (RPKM 141.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质催化甲硫氨酸和 ATP 产生 S-腺苷甲硫氨酸 (AdoMet) 。 AdoMet 是细胞过程中的关键甲基供体。[RefSeq 提供，2011 年 6 月]

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

MAT2A 基因产物(1)

mRNA	Protein	Name
NM_005911.6	NP_005902.1	S-adenosylmethionine synthase isoform type-2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables methionine adenosyltransferase activity	IDA IDA: 通过直接分析推断	7665609	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10644686	GOA
enables small molecule binding	EXP EXP: 通过实验结果推断	26858410	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in S-adenosylmethionine biosynthetic process	IDA IDA: 通过直接分析推断	10644686	GOA
involved in cellular response to methionine	IDA IDA: 通过直接分析推断	38006878	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: 通过直接分析推断	38006878	GOA
involved in protein heterooligomerization	IDA IDA: 通过直接分析推断	25075345	GOA
involved in protein hexamerization	IDA IDA: 通过直接分析推断	25075345	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of methionine adenosyltransferase complex	IDA IDA: 通过直接分析推断	10644686	GOA
part of methionine adenosyltransferase complex	IPI IPI: 通过物理相互作用推断	25075345	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAT2A 蛋白结构

S-AdoMet_synt_N

S-AdoMet_synt_M

S-AdoMet_synt_C

0
100
200
300
395 a.a.

蛋白主名

其他名称

S-adenosylmethionine synthase isoform type-2

MAT 2

MAT2A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MAT2A	P31153	MAT2B	Homo sapiens	Q9NZL9	Validated Y2H	25416956
Intra	MAT2A	P31153	MAT2B	Homo sapiens	Q9NZL9	Y2H Array	25416956
Intra	MAT2A	P31153	MAT2B	Homo sapiens	Q9NZL9	Anti Tag CoIP	33961781
Intra	MAT2A	P31153	MAT2B	Homo sapiens	Q9NZL9	Y2H Prey Pooling	25416956
Intra	MAT2A	P31153	MAT1A	Homo sapiens	Q00266	Y2H Array	32296183
Intra	MAT2A	P31153	MAT2A	Homo sapiens	P31153	Y2H Array	32296183
Intra	MAT2A	P31153	MAT2A	Homo sapiens	P31153	Y2H Prey Pooling	32296183
Intra	MAT2A	P31153	MAT1A	Homo sapiens	Q00266	Y2H Prey Pooling	32296183
Intra	MAT2A	P31153	MAT1A	Homo sapiens	Q00266	Validated Y2H	32296183
Intra	MAT2A	P31153	MAT2A	Homo sapiens	P31153	Validated Y2H	32296183
Intra	MAT2A	P31153	MAT2A	Homo sapiens	P31153	Y2H Array	25416956
Intra	MAT2A	P31153	IFI35	Homo sapiens	P80217-2	Y2H Array	32814053
Intra	MAT2A	P31153	IFI35	Homo sapiens	P80217-2	Y2H Pooling	32814053
Intra	MAT2A	P31153	IFI35	Homo sapiens	P80217-2	Validated Y2H	32814053
Intra	MAT2A	P31153	ZMYM6	Homo sapiens	O95789-4	Y2H Array	32814053
Intra	MAT2A	P31153	ZMYM6	Homo sapiens	O95789-4	Validated Y2H	32814053
Intra	MAT2A	P31153	ZMYM6	Homo sapiens	O95789-4	Y2H Pooling	32814053
Intra	MAT2A	P31153	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32814053
Intra	MAT2A	P31153	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32814053
Intra	MAT2A	P31153	KLF15	Homo sapiens	Q9UIH9	Y2H Pooling	32814053
Intra	MAT2A	P31153	FAM117B	Homo sapiens	Q6P1L5	Y2H Array	32814053
Intra	MAT2A	P31153	FAM117B	Homo sapiens	Q6P1L5	Y2H Pooling	32814053
Intra	MAT2A	P31153	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	32814053
Intra	MAT2A	P31153	CAMK1G	Homo sapiens	Q96NX5	Y2H Pooling	32814053
Intra	MAT2A	P31153	CAMK1G	Homo sapiens	Q96NX5	Validated Y2H	32814053
Intra	MAT2A	P31153	CAMK1G	Homo sapiens	Q96NX5	Y2H Array	32814053
Intra	MAT2A	P31153	CCDC141	Homo sapiens	Q6ZP82-1	Validated Y2H	32814053
Intra	MAT2A	P31153	CCDC141	Homo sapiens	Q6ZP82-1	Y2H Pooling	32814053
Intra	MAT2A	P31153	CCDC141	Homo sapiens	Q6ZP82-1	Y2H Array	32814053
Intra	MAT2A	P31153	SNW1	Homo sapiens	Q13573	Validated Y2H	32814053
Intra	MAT2A	P31153	SNW1	Homo sapiens	Q13573	Y2H Array	32814053
Intra	MAT2A	P31153	SNW1	Homo sapiens	Q13573	Y2H Pooling	32814053
Intra	MAT2A	P31153	PRC1	Homo sapiens	O43663	Y2H Array	32296183
Intra	MAT2A	P31153	PRC1	Homo sapiens	O43663	Y2H Prey Pooling	32296183
Intra	MAT2A	P31153	RBM11	Homo sapiens	P57052	Validated Y2H	32814053
Intra	MAT2A	P31153	RBM11	Homo sapiens	P57052	Y2H Array	32814053
Intra	MAT2A	P31153	RBM11	Homo sapiens	P57052	Y2H Pooling	32814053
Intra	MAT2A	P31153	GATA1	Homo sapiens	P15976-2	Validated Y2H	32814053
Intra	MAT2A	P31153	GATA1	Homo sapiens	P15976-2	Y2H Array	32814053
Intra	MAT2A	P31153	GATA1	Homo sapiens	P15976-2	Y2H Pooling	32814053
Intra	MAT2A	P31153	MT2A	Homo sapiens	P02795	Validated Y2H	32814053
Intra	MAT2A	P31153	MT2A	Homo sapiens	P02795	Y2H Array	32814053
Intra	MAT2A	P31153	MT2A	Homo sapiens	P02795	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Glycine N-Methyltransferase Deficiency

GNMT DEFICIENCY	Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency
Hypermethioninemia Due To Gnmt Deficiency	Hypermethioninemia
Hepatic Methionine Adenosyltransferase Deficiency

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency	Deficiency Of Methionine Adenosyltransferase
Glycine N-Methyltransferase Deficiency	Met
S-Adenosylhomocysteine Hydrolase Deficiency	Gnmt Deficiency
Mat Deficiency	Methionine Adenosyltransferase Deficiency
Methioninemia	Deficiency Of Acetyl-Coa Acetyltransferase

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Loeys-Dietz Syndrome

Loeys-Dietz Aortic Aneurysm Syndrome	Lds
Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies	Furlong Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-138630	AG-270		99.85%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-107778	PF-9366		99.98%	否
HY-136144	FIDAS-5		98.88%	否
HY-112130	AGI-24512	Inhibitor	99.59%	否
HY-145778	AGI-41998		99.94%	否
HY-139139	MAT2A inhibitor 3		99.27%	否
HY-145777	AGI-43192		99.53%	否
HY-112569	MAT2A inhibitor 2	Inhibitor	99.71%	否
HY-112131	MAT2A inhibitor 1		99.57%	否
HY-162353	AZ'9567	Inhibitor	99.21%	否
HY-136145	FIDAS-3	Inhibitor	99.40%	否
HY-139536	MAT2A inhibitor 4		99.84%	否
HY-169257	SCR-7952	Inhibitor	/	否
HY-142928	MAT2A-IN-1	Inhibitor	/	否
HY-142929	MAT2A-IN-2	Inhibitor	/	否
HY-142930	MAT2A-IN-3	Inhibitor	/	否
HY-144179	MAT2A-IN-4	Inhibitor	/	否
HY-144181	MAT2A-IN-5	Inhibitor	/	否
HY-144184	MAT2A-IN-6	Inhibitor	/	否
HY-144185	MAT2A-IN-7	Inhibitor	/	否
HY-149915	MAT2A-IN-10	Inhibitor	/	否
HY-155148	MAT2A-IN-11	Inhibitor	/	否
HY-155149	MAT2A-IN-12	Inhibitor	/	否
HY-159156	MAT2A inhibitor 6		/	否
HY-161298	MAT2A-IN-15	Inhibitor	/	否
HY-162010	MAT2A-IN-13	Inhibitor	/	否
HY-162135	MAT2A-IN-14		/	否
HY-163656	MAT2A inhibitor 5	Inhibitor	/	否
HY-RS08167	MAT2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MAT2A	VGNC	VGNC:50214
Canis familiaris	MAT2A	VGNC	VGNC:49922
Felis catus	MAT2A	VGNC	VGNC:68193
Rattus norvegicus	MAT2A	RGD	RGD:619985
Mus musculus	MAT2A	MGD	MGI:2443731
Macaca mulatta	MAT2A	VGNC	VGNC:74664
Others	MAT2A	NCBI

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