2. Gene
  3. MT2A - metallothionein 2A Gene

MT2A - metallothionein 2A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：金属硫蛋白 2A

种属: Homo sapiens

同用名: MT2; MT-2; MT-II

基因 ID: 4502 | 基因类型: protein coding

关于 MT2A

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,608,584-56,609,497 (from NCBI)

This gene has 5 transcripts (splice variants), 156 orthologues and 11 paralogues. Broad expression in adrenal (RPKM 718.8), liver (RPKM 608.8) and 20 other tissues.

功能概要

该基因是金属硫蛋白基因家族的成员。该基因家族编码的蛋白质分子量低，富含半胱氨酸，不含芳香族残基，可结合二价重金属离子，改变细胞内重金属的浓度。这些蛋白质充当抗氧化剂，防止羟基自由基，对细胞内金属的稳态控制很重要，并在重金属解毒中发挥作用。编码的蛋白质与某些细胞类型中含有 1 个基因的同源框编码的蛋白质相互作用，控制细胞内锌水平，影响细胞凋亡和自噬途径。该基因中的一些多态性与癌症风险增加有关。[RefSeq 提供，2017 年 9 月]

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and Autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of Cancer. [provided by RefSeq, Sep 2017]

MT2A 基因产物(1)

mRNA Protein Name
NM_005953.5 NP_005944.1 metallothionein-2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12646258 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to erythropoietin IEP
IEP: 通过表达模式推断
11168427 GOA
involved in cellular response to interleukin-3 IEP
IEP: 通过表达模式推断
11168427 GOA
involved in cellular response to zinc ion IEP
IEP: 通过表达模式推断
11168427 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MT2A 蛋白结构

Metallothio

Metallothio: Metallothionein (1 - 61)

  • 0
  • 61 a.a.
蛋白主名 其他名称

metallothionein-2

metallothionein-II

MT2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MT2A P02795 PRKD1 Homo sapiens Q15139
Y2H
14550308
种属内
MT2A P02795 PRKD1 Homo sapiens Q15139
Anti Bait CoIP
14550308
种属内
MT2A P02795 SPINK7 Homo sapiens P58062
Y2H
12646258
种属内
MT2A P02795 SPINK7 Homo sapiens P58062
Anti Tag CoIP
12646258
种属内
MT2A P02795 APOE Homo sapiens P02649
Y2H Array
32814053
种属内
MT2A P02795 APOE Homo sapiens P02649
Validated Y2H
32814053
种属内
MT2A P02795 APOE Homo sapiens P02649
Y2H Pooling
32814053
种属内
MT2A P02795 COL26A1 Homo sapiens Q96A83-2
Validated Y2H
32814053
种属内
MT2A P02795 COL26A1 Homo sapiens Q96A83-2
Y2H Array
32814053
种属内
MT2A P02795 COL26A1 Homo sapiens Q96A83-2
Y2H Pooling
32814053
种属内
MT2A P02795 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
MT2A P02795 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
MT2A P02795 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
MT2A P02795 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
种属内
MT2A P02795 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
种属内
MT2A P02795 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
种属内
MT2A P02795 ICAM5 Homo sapiens Q9UMF0
Y2H Array
32814053
种属内
MT2A P02795 ICAM5 Homo sapiens Q9UMF0
Y2H Pooling
32814053
种属内
MT2A P02795 ICAM5 Homo sapiens Q9UMF0
Validated Y2H
32814053
种属内
MT2A P02795 FLNA Homo sapiens P21333-2
Y2H Pooling
32814053
种属内
MT2A P02795 FLNA Homo sapiens P21333-2
Validated Y2H
32814053
种属内
MT2A P02795 FLNA Homo sapiens P21333-2
Y2H Array
32814053
种属内
MT2A P02795 SNCA Homo sapiens P37840
Y2H Pooling
32814053
种属内
MT2A P02795 SNCA Homo sapiens P37840
Validated Y2H
32814053
种属内
MT2A P02795 SNCA Homo sapiens P37840
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Scrapie
Osteogenesis Imperfecta, Type X

Osteogenesis Imperfecta Type 10

OI10

Osteogenesis Imperfecta Type X

Oi, Type X

Osteogenesis Imperfecta 10

Oi Type X

Oi-X
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Menkes Disease

Copper Transport Disease

Menkes Syndrome

MNK

Kinky Hair Disease

Steely Hair Disease

Menkes Kinky-Hair Syndrome

Mk

Steely Hair Syndrome

Menkea Syndrome

Md

Menkes Kinky Hair Syndrome

Hypocupremia, Congenital

Kinky Hair Syndrome

X-Linked Copper Deficiency

Menkes Kinky Hair Disease
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08743 MT2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MT2A MGD MGI:97172
Rattus norvegicus MT2A RGD RGD:1592345
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