2. Gene
  3. KLF15 - KLF transcription factor 15 Gene

KLF15 - KLF transcription factor 15 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：KLF 转录因子 15

种属: Homo sapiens

同用名: KKLF

基因 ID: 28999 | 基因类型: protein coding

关于 KLF15

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:126,288,125-126,357,408 (from NCBI)

This gene has 2 transcripts (splice variants), 251 orthologues and 22 paralogues. Broad expression in fat (RPKM 10.7), ovary (RPKM 8.2) and 17 other tissues.

功能概要

启用 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与肽酰赖氨酸乙酰化的负调节和 RNA 聚合酶 II 转录的正调节。位于核斑点。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

KLF15 基因产物(1)

mRNA Protein Name
NM_014079.4 NP_054798.1 Krueppel-like factor 15
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
19767294 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19767294 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19767294 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23999430 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of peptidyl-lysine acetylation IMP
IMP: 通过突变表型推断
20375365 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19767294 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
17438289 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLF15 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (337 - 359)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (368 - 391)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

Krueppel-like factor 15

Kruppel like factor 15

关联疾病

疾病名称 别名
Aortic Aneurysm

Aortic Rupture

Thoracoabdominal Aortic Aneurysm, Ruptured

Ruptured Aortic Aneurysm

Aortic Aneurysms

Aortic Aneurysm Without Mention Of Rupture Nos

Ruptured Abdominal Aortic Aneurysm

Aortic Aneurysm, Ruptured

Ruptured Thoracic Aortic Aneurysm
Glomerular Disease
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07336 KLF15 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KLF15 VGNC VGNC:42434
Rattus norvegicus KLF15 RGD RGD:70918
Bos taurus KLF15 VGNC VGNC:30629
Felis catus KLF15 VGNC VGNC:63132
Mus musculus KLF15 MGD MGI:1929988
Macaca mulatta KLF15 VGNC VGNC:73829
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