SNW1 - SNW domain containing 1 Gene

中文名称：含 SNW 域 1

种属: Homo sapiens

同用名: Bx42; SKIP; FUN20; Prp45; SKIIP; SKIP1; PRPF45; NCOA-62

关于 SNW1

功能概要

该基因是 SNW 基因家族的一员，编码一种共激活因子，可增强某些 Pol II 启动子的转录。这种共激活剂可以结合维生素 D 受体的配体结合域和类视黄醇受体，以增强维生素 D、视黄酸、雌激素和糖皮质激素介导的基因表达。它还可以作为剪接因子，通过与 poly (A) 结合蛋白 2 相互作用，在转录水平上直接控制肌肉特异性基因的表达。最后，该蛋白可能参与肿瘤发生，因为它与转化活性所需的 SKI 癌蛋白区域相互作用。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]