1. Gene
  2. ARL8A - ADP ribosylation factor like GTPase 8A Gene

ARL8A - ADP ribosylation factor like GTPase 8A Gene

中文名称:ADP 核糖基化因子样 GTPase 8A

种属: Homo sapiens

同用名: GIE2; ARL10B

基因 ID: 127829 | 基因类型: protein coding

关于 ARL8A

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,133,404-202,144,737 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 56.4), bone marrow (RPKM 24.8) and 25 other tissues.

功能概要

启用 GTP 绑定活动。预测参与染色体分离。位于细胞质中;中体;和主轴中间区。 [由基因组资源联盟提供,2022 年 4 月]

Enables GTP binding activity. Predicted to be involved in chromosome segregation. Located in cytoplasm; midbody; and spindle midzone. [provided by Alliance of Genome Resources, Apr 2022]

ARL8A 基因产物(2)

mRNA Protein Name
NM_001256129.2 NP_001243058.1 ADP-ribosylation factor-like protein 8A isoform 2
NM_138795.4 NP_620150.1 ADP-ribosylation factor-like protein 8A isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
15331635 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24955142 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15331635 GOA
located in midbody IDA
IDA: 通过直接分析推断
15331635 GOA
located in spindle midzone IDA
IDA: 通过直接分析推断
15331635 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ARL8A 蛋白结构

Arf

Arf: ADP-ribosylation factor family (12 - 179)

  • 0
  • 100
  • 186 a.a.
蛋白主名 其他名称

ADP-ribosylation factor-like protein 8A

ADP-ribosylation factor-like 10B

ARL8A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARL8A Q96BM9 PUF60 Homo sapiens Q9UHX1
Y2H Array
25416956
Intra ARL8A Q96BM9 PUF60 Homo sapiens Q9UHX1
Validated Y2H
25416956
Intra ARL8A Q96BM9 MOCOS Homo sapiens Q96EN8
Anti Tag CoIP
33961781
Intra ARL8A Q96BM9 MOCOS Homo sapiens Q96EN8
Validated Y2H
32296183
Intra ARL8A Q96BM9 UQCRH Homo sapiens P07919
Y2H Prey Pooling
25416956
Intra ARL8A Q96BM9 PLEKHM1 Homo sapiens Q9Y4G2
Anti Tag CoIP
28325809
Intra ARL8A Q96BM9 SPG21 Homo sapiens Q9NZD8
Anti Tag CoIP
33961781
Intra ARL8A Q96BM9 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Cross ARL8A Q96BM9 Q86500-PRO_0000041224 Rubella virus Q86500-PRO_0000041224
Protein Array
24955142
Cross ARL8A Q96BM9 Q86500-PRO_0000041224 Rubella virus Q86500-PRO_0000041224
Pull Down
24955142
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Non-Proliferative Fibrocystic Change Of The Breast

Non-Proliferative Fibrocystic Change

Breast Fibrocystic Change, Non-Proliferative Type

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ARL8A RGD RGD:1565940
Felis catus ARL8A VGNC VGNC:59929
Macaca mulatta ARL8A VGNC VGNC:69900
Bos taurus ARL8A VGNC VGNC:26153
Mus musculus ARL8A MGD MGI:1915974