MOCOS - molybdenum cofactor sulfurase Gene

中文名称：钼辅助因子硫化酶

种属: Homo sapiens

同用名: MCS; MOS; HMCS

基因 ID: 55034 | 基因类型: protein coding

关于 MOCOS

Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38): 18:36,187,497-36,272,157 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in liver (RPKM 7.8), adrenal (RPKM 7.4) and 18 other tissues.

功能概要

该基因编码一种酶，该酶可使钼辅助因子硫化，这是激活黄嘌呤脱氢酶 (XDH) 和醛氧化酶 (AO) 酶所必需的。 XDH 催化次黄嘌呤通过黄嘌呤转化为尿酸，以及别嘌醇转化为氧嘌呤醇和吡嗪酰胺转化为 5-羟基吡嗪酰胺。该基因的突变导致代谢紊乱经典黄尿症 II 型，其特征是 XDH/XO 和 AO 酶活性丧失，尿液中尿酸水平降低，血清和尿液中黄嘌呤和次黄嘌呤水平升高，形成泌尿道中的黄嘌呤结石，以及组织沉积黄嘌呤引起的肌炎。[RefSeq 提供，2017 年 4 月]

This gene encodes an Enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) Enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO Enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017]

MOCOS 基因产物(1)

mRNA	Protein	Name
NM_017947.4	NP_060417.4	molybdenum cofactor sulfurase

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables molybdenum cofactor sulfurtransferase activity	IMP IMP: 通过突变表型推断	11302742	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21516116	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in molybdopterin cofactor metabolic process	IMP IMP: 通过突变表型推断	11302742	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MOCOS 蛋白结构

Aminotran_5

MOSC_N

MOSC

0
200
400
600
800
888 a.a.

蛋白主名

其他名称

molybdenum cofactor sulfurase

MOCOS 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MOCOS	Q96EN8	ARL8A	Homo sapiens	Q96BM9	Y2H Prey Pooling	32296183
Intra	MOCOS	Q96EN8	ARL8A	Homo sapiens	Q96BM9	Y2H Array	32296183
Intra	MOCOS	Q96EN8	PARVA	Homo sapiens	Q9NVD7	Y2H Prey Pooling	25416956
Intra	MOCOS	Q96EN8	PARVA	Homo sapiens	Q9NVD7	Y2H	21516116

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Xanthinuria, Type Ii

Xanthinuria Type Ii	XAN2
Xdh And Aox Dual Deficiency	Xanthine Dehydrogenase And Aldehyde Oxidase, Combined Deficiency Of
Xanthinuria Type 2	Type 2 Xanthinuria
Type Ii Xanthinuria	Xanthine Dehydrogenase And Aldehyde Oxidase Combined Deficiency Of
Xanthine Dehydrogenase And Xanthine Aldehyde Oxidase Dual Deficiency	Xanthinuria 2
Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase	Xanthic Urolithiasis

Xanthinuria

Xanthine Dehydrogenase Deficiency	Xanthine Oxidase Deficiency
Hereditary Xanthinuria	Xanthic Urolithiasis
Xanthine Stone Disease	Xanthinuria, Type I
Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase	Xdh Deficiency
Classic Xanthinuria	Xanthinuria, Type Ii
Classical Xanthinuria	Xanthine Calculus

Purine-Pyrimidine Metabolic Disorder

Inborn Errors Of Purine-Pyrimidine Metabolism

Disorder Of Purine Or Pyrimidine Metabolism

Prolidase Deficiency

Hyperimidodipeptiduria	Imidodipeptidase Deficiency
Peptidase Deficiency	PD
Deficiency Of Prolidase	Imidodipeptiduria
Proline Dipeptidase Deficiency

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08579	MOCOS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MOCOS	RGD	RGD:1308496
Macaca mulatta	MOCOS	VGNC	VGNC:74792
Canis familiaris	MOCOS	VGNC	VGNC:43305
Felis catus	MOCOS	VGNC	VGNC:63549
Mus musculus	MOCOS	MGD	MGI:1915841
Bos taurus	MOCOS	VGNC	VGNC:31547

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MOCOS - molybdenum cofactor sulfurase Gene

关于 MOCOS

功能概要

MOCOS 基因产物(1)

MOCOS 蛋白结构

MOCOS 蛋白互作信息

关联疾病

直系同源

热门区域

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MOCOS - molybdenum cofactor sulfurase Gene

关于 MOCOS

功能概要

MOCOS 基因产物(1)

MOCOS 蛋白结构

MOCOS 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z