1. Gene
  2. PNN - pinin, desmosome associated protein Gene

PNN - pinin, desmosome associated protein Gene

中文名称:pinin,桥粒相关蛋白

种属: Homo sapiens

同用名: DRS; DRSP; SDK3; memA

基因 ID: 5411 | 基因类型: protein coding

关于 PNN

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:39,175,254-39,183,220 (from NCBI)

This gene has 6 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in bone marrow (RPKM 45.1), lymph node (RPKM 42.9) and 25 other tissues.

功能概要

启用 RNA 结合活性。预计通过剪接体参与细胞粘附和 mRNA 剪接。预测作用于细胞-细胞粘附的上游或内部。位于核斑点。催化步骤 2 剪接体的一部分。与外显子-外显子连接复合体共定位。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity. Predicted to be involved in cell adhesion and mRNA splicing, via spliceosome. Predicted to act upstream of or within cell-cell adhesion. Located in nuclear speck. Part of catalytic step 2 spliceosome. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

PNN 基因产物(1)

mRNA Protein Name
NM_002687.4 NP_002678.3 pinin

PNN 蛋白结构

Pinin_SDK_N

Pinin_SDK_N: pinin/SDK conserved region (1 - 133)

Pinin_SDK_memA

Pinin_SDK_memA: pinin/SDK/memA/ protein conserved region (134 - 264)

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  • 717 a.a.
蛋白主名 其他名称

pinin

140 kDa nuclear and cell adhesion-related phosphoprotein

PNN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PNN Q9H307 SAP18 Homo sapiens O00422
Anti Tag CoIP
33961781
Intra PNN Q9H307 SAP18 Homo sapiens O00422
Anti Tag CoIP
22388736
Intra PNN Q9H307 RNPS1 Homo sapiens Q15287-1
GMS
22388736
Intra PNN Q9H307 RNPS1 Homo sapiens Q15287-1
Pull Down
22388736
Intra PNN Q9H307 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra PNN Q9H307 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra PNN Q9H307 ACIN1 Homo sapiens Q9UKV3
Anti Tag CoIP
33961781
Intra PNN Q9H307 ACIN1 Homo sapiens Q9UKV3
Anti Tag CoIP
28514442
Intra PNN Q9H307 ACIN1 Homo sapiens Q9UKV3
Crosslink
30021884
Intra PNN Q9H307 SNW1 Homo sapiens Q13573
Crosslink
30021884
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PNN MGD MGI:1100514
Bos taurus PNN VGNC VGNC:33087
Rattus norvegicus PNN RGD RGD:1597086
Canis familiaris PNN VGNC VGNC:44748