ACIN1 - apoptotic chromatin condensation inducer 1 Gene

中文名称：凋亡染色质凝聚诱导因子 1

种属: Homo sapiens

同用名: ACN; ACINUS; fSAP152

关于 ACIN1

功能概要

细胞凋亡由几种形态学核变化定义，包括染色质浓缩和核碎裂。该基因编码一种核蛋白，该蛋白在被 Caspase-3 激活后诱导凋亡染色质浓缩，而不诱导 DNA 片段化。该蛋白质还被证明是剪接依赖性多蛋白外显子连接复合体 (EJC) 的一个组成部分，该复合体沉积在 mRNA 的剪接连接处，这是 pre-mRNA 剪接的结果。因此它可能参与与剪接相关的 mRNA 代谢。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 10 月]

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by Caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]