SART1 - spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Gene

中文名称：剪接体相关因子 1，U4/U6.U5 tri-snRNP 招募者

种属: Homo sapiens

同用名: HAF; Ara1; HOMS1; Snu66; SART1259; SNRNP110

关于 SART1

功能概要

该基因编码两种蛋白质，即在大多数增殖细胞的细胞核中表达的 SART1 (800) 蛋白质，以及在上皮癌细胞质中表达的 SART1 (259) 蛋白质。 SART1 (259) 蛋白在转录后调控过程中通过-1 移码机制进行翻译；其全长序列尚未公布。这两种编码的蛋白质被认为参与了增殖的调节。两种蛋白质都具有肿瘤排斥抗原。 SART1 (259) 蛋白具有能够在癌症患者中诱导 HLA-A2402 限制性细胞毒性 T 淋巴细胞的肿瘤表位。这种 SART1 (259) 抗原可用于癌症患者的特异性免疫治疗，并可作为特应性患者诊断和治疗的范例工具。发现 SART1 (259) 蛋白对于将 tri-snRNP 募集到剪接体组装途径中的剪接体前体至关重要。[RefSeq 提供，2008 年 7 月]

This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in Cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for Cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]