1. Gene
  2. SUMO1 - small ubiquitin like modifier 1 Gene

SUMO1 - small ubiquitin like modifier 1 Gene

中文名称:小泛素样修饰符 1

种属: Homo sapiens

同用名: DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3

基因 ID: 7341 | 基因类型: protein coding

关于 SUMO1

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:202,206,171-202,238,597 (from NCBI)

This gene has 10 transcripts (splice variants), 183 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 51.9), adrenal (RPKM 51.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是 SUMO (小泛素样修饰剂) 蛋白质家族的成员。它以类似于泛素的方式发挥作用,因为它作为翻译后修饰系统的一部分与目标蛋白质结合。然而,与靶向蛋白质降解的泛素不同,该蛋白质参与多种细胞过程,例如核转运、转录调节、细胞凋亡和蛋白质稳定性。直到羧基末端的最后四个氨基酸被切除后,它才具有活性。已经报道了该基因的几个假基因。编码不同亚型的替代转录剪接变体已经被表征。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, Apoptosis, and protein stability. It is not active until the last four Amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

SUMO1 基因产物(6)

mRNA Protein Name
NM_001005781.2 NP_001005781.1 small ubiquitin-related modifier 1 isoform a precursor
NM_001005782.2 NP_001005782.1 small ubiquitin-related modifier 1 isoform b
NM_001371392.1 NP_001358321.1 small ubiquitin-related modifier 1 isoform d
NM_001371393.1 NP_001358322.1 small ubiquitin-related modifier 1 isoform e
NM_001371394.1 NP_001358323.1 small ubiquitin-related modifier 1 isoform c
NM_003352.8 NP_003343.1 small ubiquitin-related modifier 1 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
15959518 GOA
enables potassium channel regulator activity IDA
IDA: 通过直接分析推断
19223394 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11112409 GOA
enables small protein activating enzyme binding IPI
IPI: 通过物理相互作用推断
15660128 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
18408734 GOA
enables ubiquitin-specific protease binding IPI
IPI: 通过物理相互作用推断
18538659 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cadmium ion IDA
IDA: 通过直接分析推断
11514557 GOA
involved in cellular response to heat IDA
IDA: 通过直接分析推断
11514557 GOA
involved in negative regulation of DNA binding IDA
IDA: 通过直接分析推断
16626738 GOA
involved in negative regulation of DNA binding IMP
IMP: 通过突变表型推断
15637059 GOA
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
12072434 GOA
acts upstream of negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15572661 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
12072434 GOA
involved in negative regulation of action potential IDA
IDA: 通过直接分析推断
19223394 GOA
involved in negative regulation of delayed rectifier potassium channel activity IDA
IDA: 通过直接分析推断
19223394 GOA
involved in negative regulation of protein import into nucleus IDA
IDA: 通过直接分析推断
17264123 GOA
acts upstream of negative regulation of transcription by transcription factor localization IDA
IDA: 通过直接分析推断
17264123 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
18408734 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
18579533 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
21968017 GOA
involved in protein sumoylation IDA
IDA: 通过直接分析推断
9885291 GOA
involved in protein sumoylation IMP
IMP: 通过突变表型推断
17081986 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with PML body IDA
IDA: 通过直接分析推断
9412458 GOA
located in PML body IDA
IDA: 通过直接分析推断
9885291 GOA
located in nuclear body IDA
IDA: 通过直接分析推断
24651376 GOA
located in nuclear stress granule IDA
IDA: 通过直接分析推断
11514557 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9412458 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19223394 GOA
part of voltage-gated potassium channel complex IDA
IDA: 通过直接分析推断
19223394 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SUMO1 蛋白结构

Rad60-SLD

Rad60-SLD: Ubiquitin-2 like Rad60 SUMO-like (22 - 91)

  • 0
  • 101 a.a.
蛋白主名 其他名称

small ubiquitin-related modifier 1

GAP modifying protein 1

SUMO1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SUMO1 P63165 SUMO1P1 Homo sapiens G2XKQ0 25416956
种属内
SUMO1 P63165 UBE2I Homo sapiens Q7KZS0 32296183
种属内
SUMO1 P63165 UBE2I Homo sapiens Q7KZS0 32296183
种属内
SUMO1 P63165 UBE2I Homo sapiens Q7KZS0 32296183
种属内
SUMO1 P63165 FBF1 Homo sapiens Q8TES7-6 25416956
种属内
SUMO1 P63165 FSBP Homo sapiens O95073 25416956
种属内
SUMO1 P63165 SOX10 Homo sapiens P56693 16494873
种属内
SUMO1 P63165 ATF2 Homo sapiens P15336 25416956
种属内
SUMO1 P63165 ATF2 Homo sapiens P15336 25416956
种属内
SUMO1 P63165 ATF2 Homo sapiens P15336 25416956
种属内
SUMO1 P63165 MECP2 Homo sapiens P51608 33961781
种属内
SUMO1 P63165 ZFP42 Homo sapiens Q96MM3 32296183
种属内
SUMO1 P63165 MEF2A Homo sapiens Q02078-1 19684601
种属内
SUMO1 P63165 MEF2A Homo sapiens Q02078-1 19684601
种属内
SUMO1 P63165 ELK1 Homo sapiens P19419-1 19684601
种属内
SUMO1 P63165 PSIP1 Homo sapiens O75475
IF
22748127
种属内
SUMO1 P63165 PSIP1 Homo sapiens O75475 22748127
种属内
SUMO1 P63165 RNF4 Homo sapiens P78317 32296183
种属内
SUMO1 P63165 RNF4 Homo sapiens P78317 32296183
种属内
SUMO1 P63165 RNF4 Homo sapiens P78317 32296183
种属内
SUMO1 P63165 USPL1 Homo sapiens Q5W0Q7 22878415
种属内
SUMO1 P63165 USPL1 Homo sapiens Q5W0Q7 22878415
种属内
SUMO1 P63165 ZBTB2 Homo sapiens Q8N680 32296183
种属内
SUMO1 P63165 ZBTB2 Homo sapiens Q8N680 32296183
种属内
SUMO1 P63165 ZBTB2 Homo sapiens Q8N680 32296183
种属内
SUMO1 P63165 SENP1 Homo sapiens Q9P0U3 17099698
种属内
SUMO1 P63165 SENP1 Homo sapiens Q9P0U3 17099698
种属内
SUMO1 P63165 SENP1 Homo sapiens Q9P0U3 22878415
种属内
SUMO1 P63165 SENP1 Homo sapiens Q9P0U3 17099698
种属内
SUMO1 P63165 SENP1 Homo sapiens Q9P0U3 22878415
种属内
SUMO1 P63165 SENP1 Homo sapiens Q9P0U3
ITC
17099698
种属内
SUMO1 P63165 SENP1 Homo sapiens Q9P0U3 32296183
种属内
SUMO1 P63165 EDARADD Homo sapiens Q8WWZ3 25416956
种属内
SUMO1 P63165 EDARADD Homo sapiens Q8WWZ3 25416956
种属内
SUMO1 P63165 PML Homo sapiens P29590
Y2H
11948183
种属内
SUMO1 P63165 PML Homo sapiens P29590 25497731
种属内
SUMO1 P63165 PML Homo sapiens P29590
NMR
25497731
种属内
SUMO1 P63165 PML Homo sapiens P29590
ITC
25497731
种属内
SUMO1 P63165 MYB Homo sapiens P10242 20802522
种属内
SUMO1 P63165 BTBD3 Homo sapiens Q9Y2F9 32296183
种属内
SUMO1 P63165 TDG Homo sapiens Q13569
Y2H
16763556
种属内
SUMO1 P63165 PIAS2 Homo sapiens O75928
Y2H
21988832
种属内
SUMO1 P63165 PIAS2 Homo sapiens O75928 25416956
种属内
SUMO1 P63165 PIAS2 Homo sapiens O75928 25416956
种属内
SUMO1 P63165 PIAS2 Homo sapiens O75928 25416956
种属内
SUMO1 P63165 PIAS2 Homo sapiens O75928
NMR
16204249
种属内
SUMO1 P63165 PIAS2 Homo sapiens O75928-2 32296183
种属内
SUMO1 P63165 PIAS2 Homo sapiens O75928-2 32296183
种属内
SUMO1 P63165 NPM1 Homo sapiens P06748-1 17535915
种属内
SUMO1 P63165 NPM1 Homo sapiens P06748-1 17535915
种属内
SUMO1 P63165 PARP1 Homo sapiens P09874 19779455
种属内
SUMO1 P63165 TRAF2 Homo sapiens Q12933 32296183
种属内
SUMO1 P63165 TANK Homo sapiens Q92844 21212807
种属内
SUMO1 P63165 HNRNPC Homo sapiens P07910 25416956
种属内
SUMO1 P63165 HNRNPC Homo sapiens P07910 25416956
种属内
SUMO1 P63165 TRAF4 Homo sapiens Q9BUZ4 25416956
种属内
SUMO1 P63165 TP53 Homo sapiens P04637 16732283
种属内
SUMO1 P63165 TP53 Homo sapiens P04637 20534433
种属内
SUMO1 P63165 TP53 Homo sapiens P04637 19684601
种属内
SUMO1 P63165 RHOXF2 Homo sapiens Q9BQY4 25416956
种属内
SUMO1 P63165 RHOXF2 Homo sapiens Q9BQY4 25416956
种属内
SUMO1 P63165 ZBTB26 Homo sapiens Q9HCK0 25416956
种属内
SUMO1 P63165 ZBTB26 Homo sapiens Q9HCK0 32296183
种属内
SUMO1 P63165 ZBTB26 Homo sapiens Q9HCK0 32296183
种属内
SUMO1 P63165 ZBTB26 Homo sapiens Q9HCK0 32296183
种属内
SUMO1 P63165 RANGAP1 Homo sapiens P46060 17000644
种属内
SUMO1 P63165 RANGAP1 Homo sapiens P46060 17099698
种属内
SUMO1 P63165 RARA Homo sapiens P10276
IF
24819975
种属内
SUMO1 P63165 RARA Homo sapiens P10276 24819975
种属内
SUMO1 P63165 HIF1A Homo sapiens Q16665 20661221
种属内
SUMO1 P63165 HIF1A Homo sapiens Q16665 20661221
种属内
SUMO1 P63165 SART1 Homo sapiens O43290 17000644
种属内
SUMO1 P63165 AR Homo sapiens P10275 21242980
种属内
SUMO1 P63165 AR Homo sapiens P10275 21242980
种属内
SUMO1 P63165 SOX2 Homo sapiens P48431 25416956
种属内
SUMO1 P63165 SOX2 Homo sapiens P48431 31515488
种属内
SUMO1 P63165 SP100 Homo sapiens P23497-2 32296183
种属内
SUMO1 P63165 SP100 Homo sapiens P23497-2 32296183
种属间
SUMO1 P63165 Prdm1 Mus musculus Q60636 21722636
种属内
SUMO1 P63165 TFCP2 Homo sapiens Q12800 25416956
种属内
SUMO1 P63165 UBA2 Homo sapiens Q9UBT2 25416956
种属内
SUMO1 P63165 UBA2 Homo sapiens Q9UBT2 18063693
种属内
SUMO1 P63165 UBA2 Homo sapiens Q9UBT2 31515488
种属内
SUMO1 P63165 UBA2 Homo sapiens Q9UBT2 32296183
种属内
SUMO1 P63165 UBA2 Homo sapiens Q9UBT2 25416956
种属内
SUMO1 P63165 HSF1 Homo sapiens Q00613 19684601
种属内
SUMO1 P63165 CBX4 Homo sapiens O00257 33961781
种属内
SUMO1 P63165 CBX4 Homo sapiens O00257 20098713
种属内
SUMO1 P63165 ZBTB6 Homo sapiens Q15916 25416956
种属内
SUMO1 P63165 ZBTB6 Homo sapiens Q15916 25416956
种属内
SUMO1 P63165 ZMYM5 Homo sapiens Q9UJ78 25416956
种属内
SUMO1 P63165 ZMYM5 Homo sapiens Q9UJ78 25416956
种属内
SUMO1 P63165 ZMYM5 Homo sapiens Q9UJ78 25416956
种属内
SUMO1 P63165 ZCCHC7 Homo sapiens Q8N3Z6 32296183
种属内
SUMO1 P63165 ZCCHC7 Homo sapiens Q8N3Z6 32296183
种属内
SUMO1 P63165 ZCCHC7 Homo sapiens Q8N3Z6 32296183
种属内
SUMO1 P63165 ELK1 Homo sapiens P19419 23395904
种属内
SUMO1 P63165 ELK1 Homo sapiens P19419 23395904
种属内
SUMO1 P63165 ELK1 Homo sapiens P19419 17036045
种属内
SUMO1 P63165 FAM118B Homo sapiens Q9BPY3 25416956
种属内
SUMO1 P63165 FAM118B Homo sapiens Q9BPY3 25416956
种属内
SUMO1 P63165 EIF4E Homo sapiens P06730 20224576
种属内
SUMO1 P63165 HGS Homo sapiens O14964 25416956
种属内
SUMO1 P63165 HGS Homo sapiens O14964 25416956
种属内
SUMO1 P63165 DTX2 Homo sapiens Q86UW9 25416956
种属内
SUMO1 P63165 DTX2 Homo sapiens Q86UW9 25416956
种属内
SUMO1 P63165 MAPK1IP1L Homo sapiens Q8NDC0 25416956
种属内
SUMO1 P63165 MAPK1IP1L Homo sapiens Q8NDC0 25416956
种属内
SUMO1 P63165 ARK2N Homo sapiens Q96B23 32296183
种属内
SUMO1 P63165 ARK2N Homo sapiens Q96B23 25416956
种属内
SUMO1 P63165 ARK2N Homo sapiens Q96B23 35044719
种属内
SUMO1 P63165 ARK2N Homo sapiens Q96B23 25416956
种属内
SUMO1 P63165 SATB1 Homo sapiens Q01826 18408014
种属内
SUMO1 P63165 ZCCHC12 Homo sapiens Q6PEW1 25416956
种属内
SUMO1 P63165 DEUP1 Homo sapiens Q05D60 25416956
种属内
SUMO1 P63165 DEUP1 Homo sapiens Q05D60 25416956
种属内
SUMO1 P63165 DEUP1 Homo sapiens Q05D60 25416956
种属内
SUMO1 P63165 SNIP1 Homo sapiens Q8TAD8 33961781
种属内
SUMO1 P63165 CARD9 Homo sapiens Q9H257 25416956
种属内
SUMO1 P63165 CARD9 Homo sapiens Q9H257 25416956
种属内
SUMO1 P63165 DAXX Homo sapiens Q9UER7
Y2H
11948183
种属内
SUMO1 P63165 DAXX Homo sapiens Q9UER7 11112409
种属内
SUMO1 P63165 DAXX Homo sapiens Q9UER7
Y2H
11112409
种属内
SUMO1 P63165 PRDM1 Homo sapiens O75626-2 22555612
种属内
SUMO1 P63165 DNMT3B Homo sapiens Q9UBC3
Y2H
11735126
种属内
SUMO1 P63165 DNMT3B Homo sapiens Q9UBC3 11735126
种属内
SUMO1 P63165 UBE2I Homo sapiens P63279 31515488
种属内
SUMO1 P63165 UBE2I Homo sapiens P63279 19684601
种属内
SUMO1 P63165 UBE2I Homo sapiens P63279 25502805
种属内
SUMO1 P63165 UBE2I Homo sapiens P63279 18063693
种属内
SUMO1 P63165 UBE2I Homo sapiens P63279
GMS
17491593
种属内
SUMO1 P63165 UBE2I Homo sapiens P63279 21212807
种属内
SUMO1 P63165 UBE2I Homo sapiens P63279 17491593
种属内
SUMO1 P63165 TP53BP1 Homo sapiens Q12888-1 20016603
种属内
SUMO1 P63165 IKBKG Homo sapiens Q9Y6K9 21811235
种属内
SUMO1 P63165 IKBKG Homo sapiens Q9Y6K9 21212807
种属内
SUMO1 P63165 MBD1 Homo sapiens Q9UIS9 17066076
种属内
SUMO1 P63165 MBD1 Homo sapiens Q9UIS9 17066076
种属内
SUMO1 P63165 RAD54L2 Homo sapiens Q9Y4B4 32296183
种属内
SUMO1 P63165 RAD54L2 Homo sapiens Q9Y4B4 32296183
种属内
SUMO1 P63165 RAD54L2 Homo sapiens Q9Y4B4 25416956
种属内
SUMO1 P63165 RAD54L2 Homo sapiens Q9Y4B4 32296183
种属内
SUMO1 P63165 CEBPB Homo sapiens P17676-1 18820298
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SUMO1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70997 SUMO1 Protein, Human (His) AAH66306 (M1-V101) ≥95%

SUMO1 抗体

目录号 产品名 应用 反应物种
HY-P80905 SUMO1 Antibody (YA047) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Orofacial Cleft 10

OFC10

Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 10

Nonsyndromic Cleft Lip With Or Without Cleft Palate 10

Non-Syndromic Orofacial Cleft 10

Non-Syndromic Cleft Lip/Palate 10

Non-Syndromic Cleft Lip With Or Without Cleft Palate 10

Orofacial Cleft, Type 10

Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth

Cleft Lip

Cheiloschisis

Labium Leporinum

Cleft Lip, Unilateral, Complete

Complete Unilateral Cleft Lip

Hare Lip

Congenital Fissure Of Lip

Isolated Cleft Lip

Cleft Lip Without Cleft Palate

Cleft Lip Without Cleft Palate, Unilateral

Isolated Cleft Lip, Unilateral

Cleft Lip Without Cleft Palate, Bilateral

Isolated Cleft Lip, Bilateral

Orofacial Cleft

Cleft, Orofacial

Orofacial Cleft 4

OFC4

Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 4

Nonsyndromic Cleft Lip With Or Without Cleft Palate 4

Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Unilateral Focal Polymicrogyria
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus SUMO1 VGNC VGNC:35473
Mus musculus SUMO1 MGD MGI:1197010
Rattus norvegicus SUMO1 RGD RGD:1306919
Macaca mulatta SUMO1 VGNC VGNC:99409
Others SUMO1 NCBI