2. Gene
  3. RANGAP1 - Ran GTPase activating protein 1 Gene

RANGAP1 - Ran GTPase activating protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Ran GTP 酶激活蛋白 1

种属: Homo sapiens

同用名: SD; Fug1; RANGAP

基因 ID: 5905 | 基因类型: protein coding

关于 RANGAP1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,244,779-41,302,369 (from NCBI)

This gene has 8 transcripts (splice variants) and 282 orthologues. Broad expression in testis (RPKM 19.7), skin (RPKM 13.7) and 25 other tissues.

功能概要

该基因编码一种与核孔复合体结合并参与核转运调节的蛋白质。编码的蛋白质与 Ras 相关核蛋白 1 (RAN) 相互作用并调节三磷酸鸟苷 (GTP) 结合和交换。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RANGAP1 基因产物(3)

mRNA Protein Name
NM_001278651.2 NP_001265580.1 ran GTPase-activating protein 1
NM_001317930.2 NP_001304859.1 ran GTPase-activating protein 1
NM_002883.4 NP_002874.1 ran GTPase-activating protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
16428860 GOA
enables RNA binding IDA
IDA: 通过直接分析推断
26308891 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14729961 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
16428860 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of GTPase activity IDA
IDA: 通过直接分析推断
16428860 GOA
involved in negative regulation of protein export from nucleus IDA
IDA: 通过直接分析推断
16449645 GOA
involved in nuclear export EXP
EXP: 通过实验结果推断
27160050 GOA
involved in protein sumoylation IDA
IDA: 通过直接分析推断
22194619 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SUMO ligase complex IPI
IPI: 通过物理相互作用推断
22194619 GOA
colocalizes with kinetochore IDA
IDA: 通过直接分析推断
17363900 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
25468996 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
26308891 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RANGAP1 蛋白结构

LRR_6

LRR_6: Leucine Rich repeat (113 - 132)

LRR_6

LRR_6: Leucine Rich repeat (236 - 257)

LRR_6

LRR_6: Leucine Rich repeat (292 - 312)

LRR_6

LRR_6: Leucine Rich repeat (323 - 342)

RanGAP1_C

RanGAP1_C: RanGAP1 C-terminal domain (404 - 586)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 587 a.a.
蛋白主名 其他名称

ran GTPase-activating protein 1

segregation distorter homolog

RANGAP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Bait CoIP
23395904
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
22194619
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Tag CoIP
17036045
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Bait CoIP
17000644
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
ITC
17099698
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
17099698
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Comigration in SDS
20414307
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Comigration in SDS
16732283
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
17099700
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
GMS
17099700
Intra RANGAP1 P46060 UBE2I Homo sapiens P63279
Pull Down
23395904
Intra RANGAP1 P46060 UBE2I Homo sapiens P63279
X-Ray Diffraction
22194619
Intra RANGAP1 P46060 UBE2I Homo sapiens P63279
Y2H
21988832
Intra RANGAP1 P46060 RANBP2 Homo sapiens P49792
X-Ray Diffraction
22194619
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7

PARK7

Parkinson'S Disease 7

Autosomal Recessive Early-Onset Parkinson'S Disease 7

Parkinson Disease 7

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2

Autosomal Recessive Early-Onset Parkinson Disease Type 7

Parkinson Disease, Type 7
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11650 RANGAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RANGAP1 VGNC VGNC:76656
Felis catus RANGAP1 VGNC VGNC:69235
Mus musculus RANGAP1 MGD MGI:103071
Canis familiaris RANGAP1 VGNC VGNC:45340
Bos taurus RANGAP1 VGNC VGNC:33713
Rattus norvegicus RANGAP1 RGD RGD:1310380
Others RANGAP1 NCBI
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