ELK1 - ETS transcription factor ELK1 Gene

中文名称：ETS 转录因子 ELK1

种属: Homo sapiens

基因 ID: 2002 | 基因类型: protein coding

关于 ELK1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:47,635,520-47,650,604 (from NCBI)

This gene has 4 transcripts (splice variants), 179 orthologues and 28 paralogues. Ubiquitous expression in ovary (RPKM 19.1), brain (RPKM 15.9) and 25 other tissues.

功能概要

该基因是转录因子 Ets 家族和三元复合因子 (TCF) 亚家族的成员。 TCF 亚家族的蛋白质通过与 c-fos 原癌基因启动子中的血清反应因子和血清反应元件结合形成三元复合物。由该基因编码的蛋白质是 ras-raf-MAPK 信号级联的核目标。该基因通过使用替代翻译起始密码子和选择性剪接产生多种亚型。已在 7 号和 14 号染色体上鉴定出相关的假基因。[RefSeq 提供，2012 年 3 月]

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

ELK1 基因产物(3)

mRNA	Protein	Name
NM_001114123.3	NP_001107595.1	ETS domain-containing protein Elk-1 isoform a
NM_001257168.1	NP_001244097.1	ETS domain-containing protein Elk-1 isoform b
NM_005229.4	NP_005220.2	ETS domain-containing protein Elk-1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	12750007	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	14970218	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	10799319	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	12750007	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	26612202	GOA
enables nuclear receptor coactivator activity	IMP IMP: 通过突变表型推断	31146003	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16291755	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	31146003	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15790681	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	17296730	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	31146003	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12750007	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22065586	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	20018936	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ELK1 蛋白结构

Ets

0
100
200
300
400
428 a.a.

蛋白主名

其他名称

ETS domain-containing protein Elk-1

ELK1, ETS transcription factor

ELK1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ELK1	P19419	FOXE1	Homo sapiens	O00358	Gal4 VP16 Complement	27852061
Intra	ELK1	P19419	FOXE1	Homo sapiens	O00358	Anti Bait CoIP	27852061
Intra	ELK1	P19419	MAPK3	Homo sapiens	P27361	Protein Kinase Assay	16291755
Intra	ELK1	P19419	MAPK3	Homo sapiens	P27361	PLA	25241761
Intra	ELK1	P19419	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	17036045
Intra	ELK1	P19419	UBE2I	Homo sapiens	P63279	Anti Bait CoIP	17036045

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-152860	Darizmetinib		99.94%	否
HY-135699	TD52		≥95.0%	否
HY-113592	ERK-IN-4	Inhibitor	99.61%	否
HY-135699A	TD52 dihydrochloride		99.90%	否
HY-RS04305	ELK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-163323	AKR1C3-IN-12	Inhibitor	/	否
HY-111000	BNC-1		/	否
HY-122241	MT477	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ELK1	MGD	MGI:101833
Canis familiaris	ELK1	VGNC	VGNC:40303
Felis catus	ELK1	VGNC	VGNC:61810
Rattus norvegicus	ELK1	RGD	RGD:1598663
Bos taurus	ELK1	VGNC	VGNC:28432

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ELK1 - ETS transcription factor ELK1 Gene

关于 ELK1

功能概要

ELK1 基因产物(3)

ELK1 蛋白结构

ELK1 蛋白互作信息

关联疾病

直系同源

热门区域

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ELK1 - ETS transcription factor ELK1 Gene

关于 ELK1

功能概要

ELK1 基因产物(3)

ELK1 蛋白结构

ELK1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z