2. Epigenetics TGF-beta/Smad
  3. PKC
  4. MT477

MT477 是一种有效的蛋白激酶 C (protein kinase C (PKC)) 抑制剂。MT477 可诱导细胞凋亡 (apoptosis) 和坏死 (necrosis)。MT477 可降低 Ras-GTP、p-Erk1/2、p-Elk1 的蛋白表达。MT477 具有抗肿瘤活性。

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MT477 Chemical Structure

MT477 Chemical Structure

CAS No. : 328069-91-6

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MT477 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity[1].

体外研究
(In Vitro)

MT477 (0.05 mM; 1, 24 h) 以时间依赖性方式诱导细胞凋亡和坏死[1]。
MT477 (0.05 mM; 0.5, 1, 2, 4 h) 以时间依赖性方式降低 Ras-GTP、p-Erk1/2、p-Elk1 的蛋白质表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MT477 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, U87, H226, LNCaP, A549, A431 cells
Concentration: 0.001-1 mM
Incubation Time: 1 h
Result: Showed antiproliferative activity with IC50s of 0.018, 0.051, 0.013, 0.033, 0.020, 0.049 mM for MCF-7, U87, H226, LNCaP, A549, A431 cells, respectively.

Western Blot Analysis[1]

Cell Line: H266 cells
Concentration: 0.05 mM
Incubation Time: 0.5, 1, 2, 4 h
Result: Decreased the protein expression of Ras-GTP, p-Erk1/2, p-Elk1 in a time-dependent manner.

Apoptosis Analysis[1]

Cell Line: H266 cells
Concentration: 0.05 mM
Incubation Time: 1, 24 h
Result: Induced apoptosia with the percentage of cells underwent apoptosis after 1 h of treatment of 18.6 and after 24 h of treatment of 98%.
体内研究
(In Vivo)

MT477 (33, 100, 1000 µg/kg; i.p.; once a day on days 1, 4, 8, 16, 18, 20) 显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male nude mice (A431 cells) [1]
Dosage: 33, 100, 1000 µg/kg
Administration: I.p.; once a day on days 1, 4, 8, 16, 18, 20
Result: Significant decreased in tumor volume of 24.5% by the third week at 1 mg/kg.
Animal Model: 6-week-old male nude mice (H226 cells) [1]
Dosage: 1 mg/kg
Administration: I.p.; once a day on days 1, 4, 8, 20, 24, 28
Result: Inhibited tumor growth by 43.6% and observed no weight loss.
分子量

718.77

Formula

C31H30N2O12S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MT477 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT477328069-91-6MT 477MT-477PKCProtein kinase CA431 cellsH226 cellsapoptosisnecrosisRas-GTPp-Erk1/2p-Elk1antitumorInhibitorinhibitorinhibit

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目录号：
HY-122241
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