TANK - TRAF family member associated NFKB activator Gene

中文名称：TRAF 家族成员相关的 NFKB 激活因子

种属: Homo sapiens

同用名: ITRAF; TRAF2; I-TRAF

基因 ID: 10010 | 基因类型: protein coding

关于 TANK

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,136,963-161,236,230 (from NCBI)

This gene has 23 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in appendix (RPKM 16.5), lymph node (RPKM 16.3) and 25 other tissues.

功能概要

TRAF (肿瘤坏死因子受体相关因子) 蛋白家族与肿瘤坏死因子受体超家族成员相关并转导信号。由该基因编码的蛋白质存在于细胞质中，可以与 TRAF1、TRAF2 或 TRAF3 结合，从而通过将 TRAF 隔离在细胞质中的潜伏状态来抑制 TRAF 功能。例如，该基因编码的蛋白质可以阻断 TRAF2 与 Epstein-Barr 病毒转化蛋白 LMP1 的结合，并抑制 LMP1 介导的 NF-kappa-B 激活。已经为该基因发现了编码不同同种型的三种选择性剪接的转录物变体。[RefSeq 提供，2010 年 11 月]

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

TANK 基因产物(3)

mRNA	Protein	Name
NM_001199135.3	NP_001186064.1	TRAF family member-associated NF-kappa-B activator isoform a
NM_004180.3	NP_004171.2	TRAF family member-associated NF-kappa-B activator isoform a
NM_133484.2	NP_597841.1	TRAF family member-associated NF-kappa-B activator isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to cysteine-type deubiquitinase activity	IMP IMP: 通过突变表型推断	25861989	GOA
enables deubiquitinase activator activity	IMP IMP: 通过突变表型推断	25861989	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	21931631	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12005438	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	11279055	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IMP IMP: 通过突变表型推断	25861989	GOA
involved in cellular response to interleukin-1	IMP IMP: 通过突变表型推断	25861989	GOA
involved in cellular response to ionizing radiation	IMP IMP: 通过突变表型推断	25861989	GOA
involved in cellular response to tumor necrosis factor	IMP IMP: 通过突变表型推断	25861989	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	25861989	GOA
involved in positive regulation of protein deubiquitination	IMP IMP: 通过突变表型推断	25861989	GOA
involved in positive regulation of type I interferon production	IDA IDA: 通过直接分析推断	21931631	GOA
involved in positive regulation of ubiquitin-specific protease activity	IMP IMP: 通过突变表型推断	25861989	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	21931631	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	25861989	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TANK 蛋白结构

TBD

0
100
200
300
400
425 a.a.

蛋白主名

其他名称

TRAF family member-associated NF-kappa-B activator

TRAF-interacting protein

TANK 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TANK	Q92844	TP53BP2	Homo sapiens	Q13625-3	Y2H Prey Pooling	25416956
Intra	TANK	Q92844	TP53BP2	Homo sapiens	Q13625-3	Validated Y2H	25416956
Intra	TANK	Q92844	TSC1	Homo sapiens	Q92574	Y2H Pooling	21653829
Intra	TANK	Q92844	TSC1	Homo sapiens	Q92574	Anti Tag CoIP	21653829
Intra	TANK	Q92844	SRSF11	Homo sapiens	Q05519	Validated Y2H	25416956
Intra	TANK	Q92844	IKBKE	Homo sapiens	Q14164	Crosslink	21212807
Intra	TANK	Q92844	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	17568778
Intra	TANK	Q92844	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	33961781
Intra	TANK	Q92844	TRAF2	Homo sapiens	Q12933	ViroTrap	30561431
Intra	TANK	Q92844	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	21903422
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	21903422
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Lumier	21931555
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	TAP	14743216
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Pull Down	18307994
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	ViroTrap	30561431
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Y2H	21988832
Intra	TANK	Q92844	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	33961781
Intra	TANK	Q92844	TRAF3	Homo sapiens	Q13114	ViroTrap	30561431
Intra	TANK	Q92844	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	21903422
Intra	TANK	Q92844	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	33961781
Intra	TANK	Q92844	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	TANK	Q92844	SUMO2	Homo sapiens	P61956	Pull Down	21212807
Intra	TANK	Q92844	PLK1	Homo sapiens	P53350	Anti Tag CoIP	33961781
Intra	TANK	Q92844	PLK1	Homo sapiens	P53350	Y2H	21988832
Intra	TANK	Q92844	APBA3	Homo sapiens	O96018	Anti Tag CoIP	21903422
Intra	TANK	Q92844	CEP63	Homo sapiens	Q96MT8	Y2H Prey Pooling	25416956
Intra	TANK	Q92844	CEP63	Homo sapiens	Q96MT8	Y2H Array	25416956
Intra	TANK	Q92844	IKBKG	Homo sapiens	Q9Y6K9	ViroTrap	30561431
Intra	TANK	Q92844	IKBKG	Homo sapiens	Q9Y6K9	Y2H	21988832
Cross	TANK	Q92844	OPG029	vaccinia virus	P17362	Anti Tag CoIP	21931555
Cross	TANK	Q92844	NS	Influenza A virus	P03495	Y2H	24008843
Cross	TANK	Q92844	NS	Influenza A virus	P03495	Pull Down	24008843

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nipah Virus Encephalitis

Equine Morbillivirus

Immunodeficiency 33

IMD33	X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency
X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency	X-Linked Msmd Due To Ikbkg Deficiency
X-Linked Msmd Due To Nemo Deficiency	Invasive Pneumococcal Disease, Recurrent Isolated, 2
Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly	Ipd2, Formerly
Nf-Kappa B Essential Modulator Deficiency	Familial X-Linked 1 Atypical Mycobacteriosis
Nemo Deficiency Syndrome	Amcbx1
Familial, X-Linked, Atypical Mycobacteriosis 1	Ipd2
Recurrent Isolated Invasive Pneumococcal Disease 2	X-Linked Disseminated Atypical Mycobacterial Infection Type 1
X-Linked Immunodeficiency 33, Mycobacteriosis	X-Linked Susceptibility To Mycobacterial Disease Type 1
Invasive Pneumococcal Disease, Recurrent Isolated, Type 2	Atypical Mycobacteriosis, Familial, X-Linked 1

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4

FTDALS4	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-4
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 4

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-111941	GSK8612	Inhibitor	99.62%	否
HY-152237	TBK1-IN-1	Inhibitor	99.91%	否
HY-112557	PROTAC TBK1 degrader-2	Inhibitor	98.20%	否
HY-117700	TNKS-IN-2	Inhibitor	/	否
HY-RS14197	TANK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TANK	RGD	RGD:628859
Felis catus	TANK	VGNC	VGNC:65952
Mus musculus	TANK	MGD	MGI:107676
Bos taurus	TANK	VGNC	VGNC:35594
Macaca mulatta	TANK	VGNC	VGNC:78097
Canis familiaris	TANK	VGNC	VGNC:47101
Others	TANK	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TANK - TRAF family member associated NFKB activator Gene

关于 TANK

功能概要

TANK 基因产物(3)

TANK 蛋白结构

TANK 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

TANK - TRAF family member associated NFKB activator Gene

关于 TANK

功能概要

TANK 基因产物(3)

TANK 蛋白结构

TANK 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z