IKBKE - inhibitor of nuclear factor kappa B kinase subunit epsilon Gene

中文名称：核因子 kappa B 激酶亚基 epsilon 抑制因子

种属: Homo sapiens

同用名: IKKE; IKKI; IKK-E; IKK-i

基因 ID: 9641 | 基因类型: protein coding

关于 IKBKE

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,470,476-206,496,889 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 9.0), appendix (RPKM 7.5) and 20 other tissues.

功能概要

IKBKE 是一种非经典 I-kappa-B (参见 MIM 164008) 激酶 (IKK) ，对于调节抗病毒信号通路至关重要。 IKBKE 也被确定为乳腺癌 (MIM 114480) 致癌基因，并且在超过 30% 的乳腺癌和乳腺癌细胞系中被扩增和过表达 (Hutti 等人，2009 [PubMed 19481526]) 。[OMIM 提供，10 月 2009]

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating Antiviral signaling pathways. IKBKE has also been identified as a breast Cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast Cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

IKBKE 基因产物(6)

mRNA	Protein	Name
XM_047435018.1	XP_047290974.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2
NM_001193321.2	NP_001180250.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 3
XM_047435020.1	XP_047290976.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3
NM_014002.4	NP_054721.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1
XM_005273356.3	XP_005273413.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1
NM_001193322.2	NP_001180251.1	inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 2

IKBKE 蛋白结构

Pkinase

0
200
400
600
716 a.a.

蛋白主名

其他名称

inhibitor of nuclear factor kappa-B kinase subunit epsilon

I-kappa-B kinase epsilon	IKK-epsilon
IKK-related kinase epsilon	inducible I kappa-B kinase
inducible IkappaB kinase	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

IKBKE 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IKBKE	Q14164	IRF3	Homo sapiens	Q14653	Protein Kinase Assay	19153231
种属内	IKBKE	Q14164	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	19153231
种属内	IKBKE	Q14164	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	21903422
种属内	IKBKE	Q14164	CDC37	Homo sapiens	Q16543	Lumier	25036637
种属内	IKBKE	Q14164	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
种属内	IKBKE	Q14164	DDX3X	Homo sapiens	O00571	Pull Down	18636090
种属内	IKBKE	Q14164	DDX3X	Homo sapiens	O00571	Anti Tag CoIP	20657822
种属内	IKBKE	Q14164	TANK	Homo sapiens	Q92844	Anti Tag CoIP	25852190
种属内	IKBKE	Q14164	TANK	Homo sapiens	Q92844	Lumier	21931555
种属内	IKBKE	Q14164	TBKBP1	Homo sapiens	A7MCY6	Anti Tag CoIP	17568778
种属内	IKBKE	Q14164	UCHL1	Homo sapiens	P09936	Anti Bait CoIP	17353931
种属内	IKBKE	Q14164	APPBP2	Homo sapiens	Q92624	Anti Tag CoIP	25852190
种属内	IKBKE	Q14164	MAVS	Homo sapiens	Q7Z434	Pull Down	24706939
种属内	IKBKE	Q14164	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	21903422
种属间	IKBKE	Q14164	VP35	Zaire ebolavirus	Q05127	Anti Tag CoIP	19153231
种属间	IKBKE	Q14164	VP35	Zaire ebolavirus	Q05127	Anti Bait CoIP	19153231

种属间: 跨种属相互作用 种属内: 同种属相互作用

IKBKE 抗体

目录号	产品名	应用	反应物种
HY-P81866	IKK epsilon Antibody (YA1611)	WB, IHC-P, ICC/IF, FC	Human

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Viral Infectious Disease

Arbovirus Infections	Viral Disease
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-D0162	Malachite green hemioxalate		≥98.0%	否
HY-RS06661	IKBKE Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06662	Ikbke Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06663	Ikbke Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	IKBKE	VGNC	VGNC:41921
Mus musculus	IKBKE	MGD	MGI:1929612
Bos taurus	IKBKE	VGNC	VGNC:30101
Rattus norvegicus	IKBKE	RGD	RGD:1308352
Felis catus	IKBKE	VGNC	VGNC:62899
Macaca mulatta	IKBKE	VGNC	VGNC:99977
Others	IKBKE	NCBI

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沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IKBKE - inhibitor of nuclear factor kappa B kinase subunit epsilon Gene

关于 IKBKE

功能概要

IKBKE 基因产物(6)

IKBKE 蛋白结构

IKBKE 蛋白互作信息

IKBKE 抗体

关联疾病

直系同源

热门区域

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IKBKE - inhibitor of nuclear factor kappa B kinase subunit epsilon Gene

关于 IKBKE

功能概要

IKBKE 基因产物(6)

IKBKE 蛋白结构

IKBKE 蛋白互作信息

IKBKE 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z