MAVS - mitochondrial antiviral signaling protein Gene

中文名称：线粒体抗病毒信号蛋白

种属: Homo sapiens

同用名: IPS1; VISA; IPS-1; CARDIF

基因 ID: 57506 | 基因类型: protein coding

关于 MAVS

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,846,834-3,876,118 (from NCBI)

This gene has 2 transcripts (splice variants) and 142 orthologues. Ubiquitous expression in colon (RPKM 9.9), fat (RPKM 9.0) and 25 other tissues.

功能概要

该基因编码病毒触发的 β 干扰素信号通路中必需的中间蛋白。它是激活调节 β 干扰素表达并有助于抗病毒先天免疫的转录因子所必需的。[RefSeq 提供，2020 年 7 月]

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to Antiviral innate immunity. [provided by RefSeq, Jul 2020]

MAVS 基因产物(3)

mRNA	Protein	Name
NM_001206491.2	NP_001193420.1	mitochondrial antiviral-signaling protein isoform 2
NM_001385663.1	NP_001372592.1	mitochondrial antiviral-signaling protein isoform 2
NM_020746.5	NP_065797.2	mitochondrial antiviral-signaling protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables CARD domain binding	IPI IPI: 通过物理相互作用推断	16127453	GOA
enables RIG-I binding	IDA IDA: 通过直接分析推断	16127453	GOA
enables identical protein binding	IDA IDA: 通过直接分析推断	16127453	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	16858409	GOA
enables molecular condensate scaffold activity	IDA IDA: 通过直接分析推断	27992402	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16127453	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	16127453	GOA
enables signaling adaptor activity	IDA IDA: 通过直接分析推断	20451243	GOA
enables signaling adaptor activity	IMP IMP: 通过突变表型推断	20451243	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of innate immune response	IDA IDA: 通过直接分析推断	20628368	GOA
involved in activation of innate immune response	IMP IMP: 通过突变表型推断	18818105	GOA
involved in antiviral innate immune response	IDA IDA: 通过直接分析推断	27992402	GOA
involved in cellular response to exogenous dsRNA	IMP IMP: 通过突变表型推断	16127453	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: 通过直接分析推断	16125763	GOA
involved in defense response to bacterium	IMP IMP: 通过突变表型推断	19631370	GOA
involved in defense response to virus	IDA IDA: 通过直接分析推断	20451243	GOA
acts upstream of positive effect innate immune response	IDA IDA: 通过直接分析推断	23951545	GOA
involved in innate immune response	IMP IMP: 通过突变表型推断	19609254	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	37656786	GOA
involved in negative regulation of viral genome replication	IDA IDA: 通过直接分析推断	20451243	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of IP-10 production	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: 通过直接分析推断	23582325	GOA
involved in positive regulation of chemokine (C-C motif) ligand 5 production	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: 通过突变表型推断	19609254	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of interferon-alpha production	IMP IMP: 通过突变表型推断	19609254	GOA
involved in positive regulation of interferon-beta production	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of interferon-beta production	IMP IMP: 通过突变表型推断	19609254	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	21957149	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of protein import into nucleus	IDA IDA: 通过直接分析推断	18818105	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of response to cytokine stimulus	IMP IMP: 通过突变表型推断	21957149	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: 通过直接分析推断	16127453	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	21957149	GOA
involved in positive regulation of type I interferon production	IDA IDA: 通过直接分析推断	16858409	GOA
involved in positive regulation of type I interferon-mediated signaling pathway	IDA IDA: 通过直接分析推断	16127453	GOA
involved in protein localization to mitochondrion	IDA IDA: 通过直接分析推断	23582325	GOA
involved in regulation of peroxisome organization	IMP IMP: 通过突变表型推断	20451243	GOA
involved in signal transduction	IMP IMP: 通过突变表型推断	20451243	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in mitochondrial membrane	IDA IDA: 通过直接分析推断	20451243	GOA
located in mitochondrial membrane	IDA IDA: 通过直接分析推断	20451243	GOA
is active in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	16127453	GOA
located in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	18818105	GOA
is active in mitochondrion	IDA IDA: 通过直接分析推断	16127453	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	20628368	GOA
located in peroxisomal membrane	IDA IDA: 通过直接分析推断	20451243	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

mitochondrial antiviral-signaling protein

CARD adapter inducing interferon beta

MAVS 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MAVS	Q7Z434	UBE4A	Homo sapiens	Q14139	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	MFN1	Homo sapiens	Q8IWA4	Anti Bait CoIP	20019757
Intra	MAVS	Q7Z434	CALR	Homo sapiens	P27797	Y2H Array	32814053
Intra	MAVS	Q7Z434	CALR	Homo sapiens	P27797	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	CALR	Homo sapiens	P27797	Validated Y2H	32814053
Intra	MAVS	Q7Z434	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	MAVS	Q7Z434	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	MAVS	Q7Z434	STAT1	Homo sapiens	P42224	Anti Bait CoIP	21903422
Intra	MAVS	Q7Z434	STAT1	Homo sapiens	P42224	Anti Tag CoIP	21903422
Cross	MAVS	Q7Z434	vme1_sars2	SARS-CoV-2	P0DTC5	Anti Bait CoIP	33372174
Cross	MAVS	Q7Z434	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Enzymatic Study	34544279
Cross	MAVS	Q7Z434	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Anti Tag CoIP	34544279
Cross	MAVS	Q7Z434	ns7b_sars2	SARS-CoV-2	P0DTD8	Y2H Array	36217030
Cross	MAVS	Q7Z434	ns7b_sars2	SARS-CoV-2	P0DTD8	Anti Tag CoIP	33845483
Cross	MAVS	Q7Z434	ns7b_sars	Human SARS coronavirus	Q7TFA1	Anti Tag CoIP	33845483
Intra	MAVS	Q7Z434	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	22911572
Intra	MAVS	Q7Z434	STING1	Homo sapiens	Q86WV6	Anti Bait CoIP	22000020
Intra	MAVS	Q7Z434	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	MAVS	Q7Z434	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	MAVS	Q7Z434	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	19153231
Intra	MAVS	Q7Z434	IKBKE	Homo sapiens	Q14164	Anti Tag CoIP	16177806
Intra	MAVS	Q7Z434	C1QBP	Homo sapiens	Q07021	Confocal	19164550
Intra	MAVS	Q7Z434	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	19164550
Intra	MAVS	Q7Z434	BAG6	Homo sapiens	P46379	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	MAVS	Q7Z434	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	MAVS	Q7Z434	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	DDX3X	Homo sapiens	O00571	Y2H	20127681
Intra	MAVS	Q7Z434	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	MAVS	Q7Z434	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	MAVS	Q7Z434	RIPK2	Homo sapiens	O43353	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	RIPK2	Homo sapiens	O43353	Anti Bait CoIP	21903422
Intra	MAVS	Q7Z434	TRAF6	Homo sapiens	Q9Y4K3	BLI	26385923
Intra	MAVS	Q7Z434	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	TRAF6	Homo sapiens	Q9Y4K3	Pull Down	26385923
Intra	MAVS	Q7Z434	TRAF6	Homo sapiens	Q9Y4K3	X-Ray Diffraction	26385923
Intra	MAVS	Q7Z434	ABL1	Homo sapiens	P00519	Anti Tag CoIP	19914245
Intra	MAVS	Q7Z434	IRF5	Homo sapiens	Q13568	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	OAS3	Homo sapiens	Q9Y6K5	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	IFIH1	Homo sapiens	Q9BYX4	Anti Tag CoIP	22301138
Intra	MAVS	Q7Z434	IFIH1	Homo sapiens	Q9BYX4	Anti Bait CoIP	33372174
Intra	MAVS	Q7Z434	NLRP3	Homo sapiens	Q96P20	Anti Bait CoIP	23582325
Intra	MAVS	Q7Z434	NLRP3	Homo sapiens	Q96P20	Anti Tag CoIP	23582325
Intra	MAVS	Q7Z434	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	MAVS	Q7Z434	CDH1	Homo sapiens	P12830	Validated Y2H	32814053
Intra	MAVS	Q7Z434	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	MAVS	Q7Z434	CALCOCO2	Homo sapiens	Q13137	Anti Bait CoIP	21903422
Intra	MAVS	Q7Z434	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Prey Pooling	25416956
Intra	MAVS	Q7Z434	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	25416956
Cross	MAVS	Q7Z434	orf9b_sars	Human SARS coronavirus	P59636	Confocal	25135833
Cross	MAVS	Q7Z434	orf9b_sars	Human SARS coronavirus	P59636	SRM	25135833
Cross	MAVS	Q7Z434	orf9b_sars	Human SARS coronavirus	P59636	EM	25135833
Cross	MAVS	Q7Z434	orf9b_sars	Human SARS coronavirus	P59636	Anti Tag CoIP	25135833
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Tag CoIP	19193793
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Tag CoIP	22301138
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Bait CoIP	33976430
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Confocal	22623778
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	BiFC	24478431
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Tag CoIP	21102435
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Tag CoIP	21903422
Intra	MAVS	Q7Z434	RIGI	Homo sapiens	O95786	Anti Bait CoIP	33372174
Cross	MAVS	Q7Z434	M2	Human metapneumovirus	Q6WB96	Anti Bait CoIP	23015697
Cross	MAVS	Q7Z434	M2	Human metapneumovirus	Q6WB96	Anti Tag CoIP	23015697
Cross	MAVS	Q7Z434	nsp1_rotsh	Rotavirus A	A2T3M4	Anti Tag CoIP	24643253
Cross	MAVS	Q7Z434	nsp1_rotsh	Rotavirus A	A2T3M4	Anti Bait CoIP	24643253

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mouth Disease

Mouth Diseases

Mouth Disorders

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Oropouche Fever

Oropouche Virus Disease

Oropouche Mosquito-Borne Viral Fever

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Vaccinia

Lymphocytic Choriomeningitis

Lcm	Lymphocytic Meningitis
Lymphocytic Choriomeningitis Virus Encephalomyelitis	Lymphocytic Meningoencephalitis
Non-Arthropod Borne Lymphocytic Choriomeningitis	Lcm - [Lymphocytic Choriomeningitis]
Benign Lymphocytic Meningitis	Meningitis Due To Lymphocytic Choriomeningitis Virus

Hepatitis A

Viral Hepatitis A

Viral Hepatitis, Type A

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Severe Acute Respiratory Syndrome

Sars	Sars-Cov Infection
Sars-1	Sar Deficiency
Sars - [Severe Acute Respiratory Syndrome]

Rubella

German Measles	Three Day Measles
Rubella Nos

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Combined Oxidative Phosphorylation Deficiency 4

COXPD4	Combined Oxidative Phosphorylation Defect Type 4
Combined Oxidative Phosphorylation Deficiency, Type 4

Sting-Associated Vasculopathy With Onset In Infancy

Savi	Sting-Associated Vasculopathy, Infantile Onset
Sting-Associated Vasculopathy, Infantile-Onset

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Dyschromatosis Symmetrica Hereditaria

Dyschromatosis Symmetrica Hereditaria 1	Reticulate Acropigmentation Of Dohi
DSH	Dsh1
Symmetric Dyschromatosis Of The Extremities	Rad
Familial Reticulate Acropigmentation Of Dohi	Acropigmentation Of Dohi
Symmetrical Dyschromatosis Of Extremities

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Argentine Hemorrhagic Fever

Argentinian Hemorrhagic Fever	Junin Hemorrhagic Fever
Hemorrhagic Fever, Argentinian	Ahf - [Argentinian Haemorrhagic Fever]
Argentine Haemorrhagic Fever	Junin Haemorrhagic Fever

Poliomyelitis

Polio

Infantile Paralysis

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv
Rvcl	Rvcl-S
Vasculopathy, Retinal, With Cerebral Leukodystrophy	Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Retinal Vasculopathy With Cerebral Leukodystrophy	Retinal Vasculopathy And Cerebral Leukoencephalopathy
Hereditary Vascular Retinopathy	Hvr
RVCLS	Cerebroretinal Vasculopathy, Hereditary
Cerebroretinal Vasculopathy	Herns
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly	Hereditary Cerebroretinal Vasculopathy
Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke	Hereditary Systemic Angiopathy
Hsa	Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations
Adrvcl	Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy
Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke	Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-123805	KIN1400		98.1%	否
HY-RS08176	MAVS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-113687	T145	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MAVS	VGNC	VGNC:63397
Mus musculus	MAVS	MGD	MGI:2444773
Rattus norvegicus	MAVS	RGD	RGD:1359371
Canis familiaris	MAVS	VGNC	VGNC:43044
Macaca mulatta	MAVS	VGNC	VGNC:74609
Bos taurus	MAVS	VGNC	VGNC:31268
Others	MAVS	NCBI

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