2. Gene
  3. OAS3 - 2'-5'-oligoadenylate synthetase 3 Gene

OAS3 - 2'-5'-oligoadenylate synthetase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：2'-5'-寡聚腺苷酸合成酶 3

种属: Homo sapiens

同用名: p100; p100OAS

基因 ID: 4940 | 基因类型: protein coding

关于 OAS3

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,938,474-112,973,251 (from NCBI)

This gene has 37 transcripts (splice variants), 88 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 15.4), bone marrow (RPKM 10.1) and 24 other tissues.

功能概要

该基因编码 2', 5' 寡聚腺苷酸合酶家族中的一种酶。该酶由干扰素诱导并催化腺苷的 2'、5' 寡聚体以结合并激活 RNase L。该酶家族在抑制细胞蛋白质合成和抗病毒感染方面发挥重要作用。[RefSeq 提供，2008 年 7 月]

This gene encodes an Enzyme included in the 2', 5' oligoadenylate synthase family. This Enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This Enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral Infection resistance. [provided by RefSeq, Jul 2008]

OAS3 基因产物(2)

mRNA Protein Name
NM_001410984.1 NP_001397913.1 2'-5'-oligoadenylate synthase 3 isoform 2
NM_006187.4 NP_006178.2 2'-5'-oligoadenylate synthase 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 2'-5'-oligoadenylate synthetase activity IDA
IDA: 通过直接分析推断
9880533 GOA
enables ATP binding IDA
IDA: 通过直接分析推断
9880533 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
9880533 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21903422 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in MDA-5 signaling pathway IMP
IMP: 通过突变表型推断
30078389 GOA
involved in RIG-I signaling pathway IMP
IMP: 通过突变表型推断
30078389 GOA
involved in defense response to bacterium IMP
IMP: 通过突变表型推断
30822544 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
19923450 GOA
involved in negative regulation of IP-10 production IMP
IMP: 通过突变表型推断
30078389 GOA
involved in negative regulation of chemokine (C-C motif) ligand 5 production IMP
IMP: 通过突变表型推断
30078389 GOA
involved in negative regulation of chemokine (C-X-C motif) ligand 2 production IMP
IMP: 通过突变表型推断
30078389 GOA
involved in negative regulation of chemokine (C-X-C motif) ligand 9 production IMP
IMP: 通过突变表型推断
30078389 GOA
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
30078389 GOA
involved in negative regulation of viral genome replication IDA
IDA: 通过直接分析推断
19056102 GOA
involved in positive regulation of interferon-beta production IMP
IMP: 通过突变表型推断
30822544 GOA
involved in positive regulation of monocyte chemotactic protein-1 production IMP
IMP: 通过突变表型推断
30822544 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
30822544 GOA
involved in regulation of ribonuclease activity IDA
IDA: 通过直接分析推断
19923450 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
19056102 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9880533 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OAS3 蛋白结构

OAS1_C

OAS1_C: 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus (160 - 342)

OAS1_C

OAS1_C: 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus (559 - 745)

NTP_transf_2

NTP_transf_2: Nucleotidyltransferase domain (783 - 845)

OAS1_C

OAS1_C: 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus (903 - 1085)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1087 a.a.
蛋白主名 其他名称

2'-5'-oligoadenylate synthase 3

(2-5')oligo(A) synthase 3

OAS3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra OAS3 Q9Y6K5 DHX30 Homo sapiens Q7L2E3
Anti Tag CoIP
21903422
Intra OAS3 Q9Y6K5 IFRD2 Homo sapiens Q12894
Anti Tag CoIP
21903422
Intra OAS3 Q9Y6K5 EIF6 Homo sapiens P56537
Anti Tag CoIP
21903422
Intra OAS3 Q9Y6K5 FTSJ3 Homo sapiens Q8IY81
Anti Tag CoIP
21903422
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies
Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis

Encephalitis, Tick-Borne

Central European Encephalitis

Far Eastern Tbe

Russian Spring-Summer Encephalitis

Taiga Encephalitis

West-Siberian Encephalitis

Western European Tick-Borne Encephalitis

Tbe

Encephalitis Tick-Borne

Encephalitis, Central European

Encephalitis, Far Eastern Russian
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09729 OAS3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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