1. Gene
  2. PSIP1 - PC4 and SRSF1 interacting protein 1 Gene

PSIP1 - PC4 and SRSF1 interacting protein 1 Gene

中文名称:PC4 和 SRSF1 相互作用蛋白 1

种属: Homo sapiens

同用名: p52; p75; PAIP; DFS70; LEDGF; PSIP2

基因 ID: 11168 | 基因类型: protein coding

关于 PSIP1

Cytogenetic location: 9p22.3 Genomic coordinates (GRCh38): 9:15,464,066-15,510,970 (from NCBI)

This gene has 11 transcripts (splice variants), 255 orthologues, 4 paralogues and is associated with 66 phenotypes. Ubiquitous expression in brain (RPKM 41.2), ovary (RPKM 33.4) and 24 other tissues.

功能概要

启用 DNA 结合转录因子结合活性;染色质结合活性;和转录共激活因子活性。参与 mRNA 5'-剪接位点识别和 RNA 聚合酶 II 对转录的正调控。位于异染色质;核外围;和核质。 [由基因组资源联盟提供,2022 年 4 月]

Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coactivator activity. Involved in mRNA 5'-splice site recognition and positive regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear periphery; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PSIP1 基因产物(5)

mRNA Protein Name
NM_001128217.3 NP_001121689.1 PC4 and SFRS1-interacting protein isoform 2
NM_001317898.3 NP_001304827.1 PC4 and SFRS1-interacting protein isoform 3
NM_001317900.3 NP_001304829.1 PC4 and SFRS1-interacting protein isoform 4
NM_021144.4 NP_066967.3 PC4 and SFRS1-interacting protein isoform 1
NM_033222.5 NP_150091.2 PC4 and SFRS1-interacting protein isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IDA
IDA: 通过直接分析推断
9822615 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
20974633 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9885563 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
9822615 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA 5'-splice site recognition IDA
IDA: 通过直接分析推断
9885563 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9822615 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in heterochromatin IDA
IDA: 通过直接分析推断
12796494 GOA
located in nuclear periphery IDA
IDA: 通过直接分析推断
11512661 GOA
NOT located in nucleolus IDA
IDA: 通过直接分析推断
11512661 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
9885563 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12796494 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PSIP1 蛋白结构

PWWP

PWWP: PWWP domain (5 - 85)

LEDGF

LEDGF: Lens epithelium-derived growth factor (LEDGF) (349 - 454)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 530 a.a.
蛋白主名 其他名称

PC4 and SFRS1-interacting protein

CLL-associated antigen KW-7

PSIP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PSIP1 O75475 RBBP8 Homo sapiens Q99708 22773103
种属内
PSIP1 O75475 RBBP8 Homo sapiens Q99708 22773103
种属间
PSIP1 O75475 gag-pol Human immunodeficiency virus P04585 21156026
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PSIP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79208 LEDGF p52 Protein, Human O75475-2/NP_066967 (M1-Q333) ≥95%

关联疾病

疾病名称 别名
Olfactory Neuroblastoma

Esthesioneuroblastoma

Asthesioneuroblastoma

Esthesioneuroepithelioma

Olfactory Esthesioneuroblastoma

Paranasal Sinus Olfactory Neuroblastoma

Esthesioneuroblastoma, Olfactory

Esthesioneuroblastoma Of Nasal Cavity

Interstitial Cystitis

Bladder Pain Syndrome

Painful Bladder Syndrome

Ulcerative Cystitis

Ic/Bps

Ic/Pbs

Interstitial Cystitis/Bladder Pain Syndrome

Interstitial Cystitis/Painful Bladder Syndrome

Cystitis, Interstitial

Chronic Interstitial Cystitis

Pelvic Congestion Syndrome

Trigonitis

Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Granulomatous Disease, Chronic, X-Linked

CGDX

Chronic Granulomatous Disease, X-Linked

X-Linked Chronic Granulomatous Disease

Cgd

Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked

Cdgx

X-Linked Chronic Cytochrome B-Negative Granulomatous Disease

Chronic Granulomatous Disease Cytochrome B-Negative X-Linked

Chronic Granulomatous Disease Cytochrome B-Positive X-Linked

Granulomatous Disease, Chronic, X-Linked, Variant

Retinal Degeneration

Degeneration Of Retina

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1

MEN1

Wermer Syndrome

Multiple Endocrine Neoplasia 1

Multiple Endocrine Neoplasia, Type 1

Men I

Endocrine Adenomatosis, Multiple

Mea I

Men Type I

Wermer'S Syndrome

Men1 Syndrome

Multiple Endocrine Adenomatosis

Endocrine Adenomatosis Multiple

Men 1

Familial Multiple Endocrine Neoplasia Type I

Neoplasia, Endocrine, Multiple, Type 1

Multiple Endocrine Neoplasia

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PSIP1 VGNC VGNC:76437
Mus musculus PSIP1 MGD MGI:2142116
Rattus norvegicus PSIP1 RGD RGD:631439
Canis familiaris PSIP1 VGNC VGNC:45087
Felis catus PSIP1 VGNC VGNC:69103
Bos taurus PSIP1 VGNC VGNC:33436
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