2. Gene
  3. MISP - mitotic spindle positioning Gene

MISP - mitotic spindle positioning Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：有丝分裂纺锤体定位

种属: Homo sapiens

同用名: MISP1; C19orf21

基因 ID: 126353 | 基因类型: protein coding

关于 MISP

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:748,438-764,318 (from NCBI)

This gene has 2 transcripts (splice variants), 136 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 92.0), duodenum (RPKM 77.1) and 6 other tissues.

功能概要

该基因编码的蛋白质是一种肌动蛋白结合蛋白，参与决定细胞形态和有丝分裂进程。编码的蛋白质是有丝分裂纺锤体正确定位所必需的。已发现该基因的两种转录变体，一种是蛋白质编码，另一种是非蛋白质编码。[RefSeq 提供，2016 年 2 月]

The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]

MISP 基因产物(1)

mRNA Protein Name
NM_173481.4 NP_775752.1 mitotic interactor and substrate of PLK1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IMP
IMP: 通过突变表型推断
23509069 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23509069 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration IMP
IMP: 通过突变表型推断
23574715 GOA
involved in establishment of centrosome localization IMP
IMP: 通过突变表型推断
23509069 GOA
involved in establishment of mitotic spindle orientation IMP
IMP: 通过突变表型推断
23509069 GOA
involved in mitotic spindle assembly IMP
IMP: 通过突变表型推断
23574715 GOA
involved in organelle localization IMP
IMP: 通过突变表型推断
23574715 GOA
involved in regulation of protein localization to cell cortex IMP
IMP: 通过突变表型推断
23509069 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin filament IMP
IMP: 通过突变表型推断
23574715 GOA
colocalizes with cortical actin cytoskeleton IMP
IMP: 通过突变表型推断
23509069 GOA
colocalizes with focal adhesion IMP
IMP: 通过突变表型推断
23509069 GOA
located in focal adhesion IMP
IMP: 通过突变表型推断
23574715 GOA
colocalizes with mitotic spindle astral microtubule end IMP
IMP: 通过突变表型推断
23509069 GOA
located in spindle pole centrosome IMP
IMP: 通过突变表型推断
23574715 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MISP 蛋白结构

AKAP2_C

AKAP2_C: A-kinase anchor protein 2 C-terminus (325 - 674)

  • 0
  • 200
  • 400
  • 600
  • 679 a.a.
蛋白主名 其他名称

mitotic interactor and substrate of PLK1

caprice

MISP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MISP Q8IVT2 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra MISP Q8IVT2 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra MISP Q8IVT2 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 DPH2 Homo sapiens Q9BQC3
Validated Y2H
32296183
Intra MISP Q8IVT2 DPH2 Homo sapiens Q9BQC3
Y2H Array
32296183
Intra MISP Q8IVT2 DPH2 Homo sapiens Q9BQC3
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra MISP Q8IVT2 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 RIBC1 Homo sapiens Q8N443
Y2H Array
32296183
Intra MISP Q8IVT2 RIBC1 Homo sapiens Q8N443
Validated Y2H
32296183
Intra MISP Q8IVT2 RIBC1 Homo sapiens Q8N443
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PPP1R16B Homo sapiens Q96T49
Validated Y2H
32296183
Intra MISP Q8IVT2 PPP1R16B Homo sapiens Q96T49
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PPP1R16B Homo sapiens Q96T49
Y2H Array
32296183
Intra MISP Q8IVT2 EZR Homo sapiens P15311
Anti Tag CoIP
28514442
Intra MISP Q8IVT2 EZR Homo sapiens P15311
Anti Tag CoIP
33961781
Intra MISP Q8IVT2 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra MISP Q8IVT2 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra MISP Q8IVT2 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra MISP Q8IVT2 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra MISP Q8IVT2 BOLL Homo sapiens Q8N9W6-4
Y2H Array
32296183
Intra MISP Q8IVT2 BOLL Homo sapiens Q8N9W6-4
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 BOLL Homo sapiens Q8N9W6-4
Validated Y2H
32296183
Intra MISP Q8IVT2 SPATC1L Homo sapiens Q9H0A9-2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 SPATC1L Homo sapiens Q9H0A9-2
Validated Y2H
32296183
Intra MISP Q8IVT2 SPATC1L Homo sapiens Q9H0A9-2
Y2H Array
32296183
Intra MISP Q8IVT2 MORN5 Homo sapiens Q5VZ52
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 MORN5 Homo sapiens Q5VZ52
Y2H Array
32296183
Intra MISP Q8IVT2 SOCS7 Homo sapiens O14512
Y2H Array
32296183
Intra MISP Q8IVT2 SOCS7 Homo sapiens O14512
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PRR5L Homo sapiens Q6MZQ0
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PRR5L Homo sapiens Q6MZQ0
Y2H Array
32296183
Intra MISP Q8IVT2 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra MISP Q8IVT2 SF3A2 Homo sapiens Q15428
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 SF3A2 Homo sapiens Q15428
Y2H Array
32296183
Intra MISP Q8IVT2 CRBN Homo sapiens Q96SW2
Validated Y2H
32296183
Intra MISP Q8IVT2 CRBN Homo sapiens Q96SW2
Y2H Array
32296183
Intra MISP Q8IVT2 CRBN Homo sapiens Q96SW2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra MISP Q8IVT2 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra MISP Q8IVT2 MAP1LC3C Homo sapiens Q9BXW4
Y2H Array
32296183
Intra MISP Q8IVT2 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra MISP Q8IVT2 MAP1LC3C Homo sapiens Q9BXW4
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 CDPF1 Homo sapiens Q6NVV7
Y2H Array
32296183
Intra MISP Q8IVT2 CDPF1 Homo sapiens Q6NVV7
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PNMA2 Homo sapiens Q9UL42
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PNMA2 Homo sapiens Q9UL42
Validated Y2H
32296183
Intra MISP Q8IVT2 PNMA2 Homo sapiens Q9UL42
Y2H Array
32296183
Intra MISP Q8IVT2 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra MISP Q8IVT2 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PFDN5 Homo sapiens Q99471
Validated Y2H
32296183
Intra MISP Q8IVT2 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra MISP Q8IVT2 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PIH1D1 Homo sapiens Q9NWS0
Y2H Array
32296183
Intra MISP Q8IVT2 PIH1D1 Homo sapiens Q9NWS0
Validated Y2H
32296183
Intra MISP Q8IVT2 PIH1D1 Homo sapiens Q9NWS0
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 VBP1 Homo sapiens P61758
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 VBP1 Homo sapiens P61758
Y2H Array
32296183
Intra MISP Q8IVT2 SPATS1 Homo sapiens Q496A3
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 SPATS1 Homo sapiens Q496A3
Y2H Array
32296183
Intra MISP Q8IVT2 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra MISP Q8IVT2 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TRIB3 Homo sapiens Q96RU7
Validated Y2H
32296183
Intra MISP Q8IVT2 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra MISP Q8IVT2 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra MISP Q8IVT2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra MISP Q8IVT2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra MISP Q8IVT2 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra MISP Q8IVT2 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 SNW1 Homo sapiens Q13573
Y2H Array
32296183
Intra MISP Q8IVT2 FHL2 Homo sapiens Q14192
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 FHL2 Homo sapiens Q14192
Y2H Array
32296183
Intra MISP Q8IVT2 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra MISP Q8IVT2 DPPA4 Homo sapiens Q7L190
Y2H Array
32296183
Intra MISP Q8IVT2 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TERF1 Homo sapiens P54274-2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TERF1 Homo sapiens P54274-2
Y2H Array
32296183
Intra MISP Q8IVT2 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra MISP Q8IVT2 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra MISP Q8IVT2 HSPB8 Homo sapiens Q9UJY1
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
32296183
Intra MISP Q8IVT2 HSPB8 Homo sapiens Q9UJY1
Y2H Array
32296183
Intra MISP Q8IVT2 HSPB2 Homo sapiens Q16082
Y2H Array
32296183
Intra MISP Q8IVT2 HSPB2 Homo sapiens Q16082
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra MISP Q8IVT2 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra MISP Q8IVT2 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra MISP Q8IVT2 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra MISP Q8IVT2 ENKD1 Homo sapiens Q9H0I2
Y2H Array
32296183
Intra MISP Q8IVT2 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra MISP Q8IVT2 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra MISP Q8IVT2 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra MISP Q8IVT2 FHL5 Homo sapiens Q5TD97
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 FHL5 Homo sapiens Q5TD97
Y2H Array
32296183
Intra MISP Q8IVT2 LMO1 Homo sapiens P25800
Y2H Array
32296183
Intra MISP Q8IVT2 LMO1 Homo sapiens P25800
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 IRAK1BP1 Homo sapiens Q5VVH5
Y2H Array
32296183
Intra MISP Q8IVT2 IRAK1BP1 Homo sapiens Q5VVH5
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra MISP Q8IVT2 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis Type 22

Als 22

Amyotrohpic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 22
Prostatic Adenoma

Prostatic Hyperplasia

Adenoma - Prostate

Adenoma Of Prostate

Benign Adenoma Of Prostate

Prostate Adenoma

Benign Prostatic Hyperplasia
Male Reproductive Organ Benign Neoplasm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08465 MISP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08466 MISP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MISP VGNC VGNC:43246
Felis catus MISP VGNC VGNC:63519
Bos taurus MISP VGNC VGNC:31486
Rattus norvegicus MISP RGD RGD:1595680
Mus musculus MISP MGD MGI:1926156
Macaca mulatta MISP VGNC VGNC:74840
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