1. Gene
  2. SOCS7 - suppressor of cytokine signaling 7 Gene

SOCS7 - suppressor of cytokine signaling 7 Gene

中文名称:细胞因子信号抑制因子 7

种属: Homo sapiens

同用名: NAP4; NCKAP4

基因 ID: 30837 | 基因类型: protein coding

关于 SOCS7

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,351,844-38,405,593 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 252 orthologues and 7 paralogues. Broad expression in testis (RPKM 18.1), brain (RPKM 7.5) and 24 other tissues.

功能概要

预计可启用 1-磷脂酰肌醇-3-激酶调节剂活性。预测参与磷脂酰肌醇磷酸盐的生物合成过程。预计在几个过程的上游或内部起作用,包括大脑发育;脂肪细胞分化;和胰岛素受体信号通路。位于胞质溶胶中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within several processes, including brain development; fat cell differentiation; and Insulin Receptor signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SOCS7 基因产物(1)

mRNA Protein Name
NM_014598.4 NP_055413.2 suppressor of cytokine signaling 7
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17803907 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
17803907 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

suppressor of cytokine signaling 7

NAP-4

SOCS7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SOCS7 O14512 NSMF Homo sapiens Q6X4W1-2
Validated Y2H
32296183
Intra SOCS7 O14512 SORBS2 Homo sapiens O94875-10
Validated Y2H
32296183
Intra SOCS7 O14512 MISP Homo sapiens Q8IVT2
Validated Y2H
32296183
Intra SOCS7 O14512 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra SOCS7 O14512 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra SOCS7 O14512 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra SOCS7 O14512 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra SOCS7 O14512 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra SOCS7 O14512 GRB2 Homo sapiens P62993
Validated Y2H
32296183
Intra SOCS7 O14512 YES1 Homo sapiens P07947
Validated Y2H
32296183
Intra SOCS7 O14512 NCK2 Homo sapiens O43639
Validated Y2H
32296183
Intra SOCS7 O14512 NCK2 Homo sapiens O43639
Anti Tag CoIP
33961781
Intra SOCS7 O14512 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra SOCS7 O14512 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra SOCS7 O14512 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra SOCS7 O14512 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
32296183
Intra SOCS7 O14512 HSPB8 Homo sapiens Q9UJY1
Y2H Array
32296183
Intra SOCS7 O14512 HSPB8 Homo sapiens Q9UJY1
Y2H Prey Pooling
32296183
Intra SOCS7 O14512 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
Intra SOCS7 O14512 SORBS3 Homo sapiens O60504
Validated Y2H
32296183
Intra SOCS7 O14512 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra SOCS7 O14512 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra SOCS7 O14512 GAS2L2 Homo sapiens Q8NHY3
Validated Y2H
32296183
Intra SOCS7 O14512 TNS2 Homo sapiens Q63HR2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Uvulitis

Acute Uvulitis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SOCS7 MGD MGI:2651588
Canis familiaris SOCS7 VGNC VGNC:55821
Macaca mulatta SOCS7 VGNC VGNC:77792
Felis catus SOCS7 VGNC VGNC:65566
Rattus norvegicus SOCS7 RGD RGD:1307720
Bos taurus SOCS7 VGNC VGNC:35125