2. Gene
  3. ARL8B - ADP ribosylation factor like GTPase 8B Gene

ARL8B - ADP ribosylation factor like GTPase 8B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADP 核糖基化因子样 GTPase 8B

种属: Homo sapiens

同用名: Gie1; ARL10C

基因 ID: 55207 | 基因类型: protein coding

关于 ARL8B

Cytogenetic location: 3p26.1 Genomic coordinates (GRCh38): 3:5,122,292-5,180,911 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 30 paralogues. Ubiquitous expression in brain (RPKM 48.8), thyroid (RPKM 43.1) and 25 other tissues.

功能概要

启用胍基核糖核苷酸结合活性和微管蛋白结合活性。参与多个过程，包括钙离子调节的溶酶体胞吐作用；溶酶体运输；和囊泡融合。位于溶细胞颗粒膜；中体;和主轴中间区。与溶酶体膜共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including calcium ion regulated lysosome exocytosis; lysosomal transport; and vesicle fusion. Located in cytolytic granule membrane; midbody; and spindle midzone. Colocalizes with lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARL8B 基因产物(1)

mRNA Protein Name
NM_018184.3 NP_060654.1 ADP-ribosylation factor-like protein 8B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein activity IDA
IDA: 通过直接分析推断
16537643 GOA
enables GDP binding IDA
IDA: 通过直接分析推断
15331635 GOA
enables GDP binding IMP
IMP: 通过突变表型推断
16650381 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
15331635 GOA
enables GTP binding IMP
IMP: 通过突变表型推断
16650381 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
16537643 GOA
enables alpha-tubulin binding IDA
IDA: 通过直接分析推断
15331635 GOA
enables beta-tubulin binding IDA
IDA: 通过直接分析推断
15331635 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21802320 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antigen processing and presentation following phagocytosis IMP
IMP: 通过突变表型推断
21802320 GOA
involved in autophagosome-lysosome fusion IMP
IMP: 通过突变表型推断
28325809 GOA
involved in calcium ion regulated lysosome exocytosis IMP
IMP: 通过突变表型推断
29592961 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
14871887 GOA
involved in early endosome to Golgi transport IDA
IDA: 通过直接分析推断
36282215 GOA
involved in endosome to lysosome transport of low-density lipoprotein particle IMP
IMP: 通过突变表型推断
21802320 GOA
involved in late endosome to lysosome transport IMP
IMP: 通过突变表型推断
28325809 GOA
involved in lysosome localization IDA
IDA: 通过直接分析推断
16537643 GOA
involved in lysosome localization IMP
IMP: 通过突变表型推断
16650381 GOA
involved in natural killer cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
24088571 GOA
involved in phagosome-lysosome fusion IMP
IMP: 通过突变表型推断
21802320 GOA
involved in plasma membrane repair IMP
IMP: 通过突变表型推断
29592961 GOA
involved in protein localization to early endosome IDA
IDA: 通过直接分析推断
36282215 GOA
involved in viral exocytosis IMP
IMP: 通过突变表型推断
33157038 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytolytic granule membrane IDA
IDA: 通过直接分析推断
24088571 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15331635 GOA
is active in early endosome membrane IDA
IDA: 通过直接分析推断
36282215 GOA
colocalizes with lysosomal membrane IDA
IDA: 通过直接分析推断
25898167 GOA
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
27808481 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
22172677 GOA
located in lysosome IDA
IDA: 通过直接分析推断
21802320 GOA
located in lysosome IMP
IMP: 通过突变表型推断
16650381 GOA
located in midbody IDA
IDA: 通过直接分析推断
15331635 GOA
located in spindle midzone IDA
IDA: 通过直接分析推断
15331635 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARL8B 蛋白结构

Arf

Arf: ADP-ribosylation factor family (11 - 179)

  • 0
  • 100
  • 186 a.a.
蛋白主名 其他名称

ADP-ribosylation factor-like protein 8B

ADP-ribosylation factor-like 10C

ARL8B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARL8B Q9NVJ2 SLC30A8 Homo sapiens Q8IWU4
Y2H Array
32296183
种属内
ARL8B Q9NVJ2 SLC30A8 Homo sapiens Q8IWU4
Y2H Prey Pooling
32296183
种属内
ARL8B Q9NVJ2 PLEKHM1 Homo sapiens Q9Y4G2
Y3H
28325809
种属内
ARL8B Q9NVJ2 PLEKHM1 Homo sapiens Q9Y4G2
Filter Binding
28325809
种属内
ARL8B Q9NVJ2 PLEKHM1 Homo sapiens Q9Y4G2
Pull Down
28325809
种属内
ARL8B Q9NVJ2 PLEKHM1 Homo sapiens Q9Y4G2
Confocal
28325809
种属内
ARL8B Q9NVJ2 PLEKHM1 Homo sapiens Q9Y4G2
Anti Tag CoIP
28325809
种属内
ARL8B Q9NVJ2 PLEKHM1 Homo sapiens Q9Y4G2
TEM
28325809
种属内
ARL8B Q9NVJ2 SNW1 Homo sapiens Q13573
Y3H
28325809
种属内
ARL8B Q9NVJ2 SNW1 Homo sapiens Q13573
Pull Down
28325809
种属内
ARL8B Q9NVJ2 SNW1 Homo sapiens Q13573
Anti Tag CoIP
28325809
种属内
ARL8B Q9NVJ2 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
种属内
ARL8B Q9NVJ2 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
种属内
ARL8B Q9NVJ2 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
种属内
ARL8B Q9NVJ2 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属内
ARL8B Q9NVJ2 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spondylometaphyseal Dysplasia, Sedaghatian Type

SMDS

Sedaghatian Chondrodysplasia

Spondylometaphyseal Dysplasia Sedaghatian Type

Congenital Lethal Metaphyseal Chondrodysplasia

Metaphyseal Chondrodysplasia, Congenital Lethal

Lethal Metaphyseal Dysplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00999 ARL8B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ARL8B VGNC VGNC:84238
Rattus norvegicus ARL8B RGD RGD:1562830
Mus musculus ARL8B MGD MGI:1914416
Canis familiaris ARL8B VGNC VGNC:38122
Felis catus ARL8B VGNC VGNC:59930
Bos taurus ARL8B VGNC VGNC:26154
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