2. Gene
  3. NMT2 - N-myristoyltransferase 2 Gene

NMT2 - N-myristoyltransferase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-肉豆蔻酰转移酶 2

种属: Homo sapiens

基因 ID: 9397 | 基因类型: protein coding

关于 NMT2

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:15,105,700-15,168,693 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 9.3), testis (RPKM 5.5) and 24 other tissues.

功能概要

该基因编码两种 N-肉豆蔻酰转移酶蛋白中的一种。 N-末端豆蔻酰化是一种脂质修饰，参与调节信号蛋白的功能和定位。编码的蛋白质催化肉豆蔻酰基添加到许多信号蛋白的 N 末端甘氨酸残基，包括人类免疫缺陷病毒 1 型 (HIV-1) 蛋白 Gag 和 Nef。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 4 月]

This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

NMT2 基因产物(2)

mRNA Protein Name
NM_001308295.2 NP_001295224.1 glycylpeptide N-tetradecanoyltransferase 2 isoform 2
NM_004808.3 NP_004799.1 glycylpeptide N-tetradecanoyltransferase 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycylpeptide N-tetradecanoyltransferase activity IDA
IDA: 通过直接分析推断
25255805 GOA
enables peptidyl-lysine N6-myristoyltransferase activity IDA
IDA: 通过直接分析推断
32103017 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16530191 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-terminal peptidyl-glycine N-myristoylation IDA
IDA: 通过直接分析推断
25255805 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9506952 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
9506952 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NMT2 蛋白结构

NMT

NMT: Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain (143 - 296)

NMT_C

NMT_C: Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain (310 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 498 a.a.
蛋白主名 其他名称

glycylpeptide N-tetradecanoyltransferase 2

NMT 2

关联疾病

疾病名称 别名
Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-147308 PCLX-001 Activator 99.05% Phase 1
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112258 IMP-1088 Inhibitor 99.16% 否
HY-RS09390 NMT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NMT2 MGD MGI:1202298
Canis familiaris NMT2 VGNC VGNC:52219
Rattus norvegicus NMT2 RGD RGD:1303175
Felis catus NMT2 VGNC VGNC:68508
Macaca mulatta NMT2 VGNC VGNC:75361
Bos taurus NMT2 VGNC VGNC:32138
Others NMT2 NCBI
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